The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo
Introduction The aim of our study is to investigate the effect of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus (DG) region of the rat hippocampus. Material and methods Seven-day-old healthy Sprague Dawley (SD) rats were randomly divided into a control group and an experiment grou...
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oai:doaj.org-article:49bb105e40024e52b6944b544dcf4b952021-12-02T18:39:22ZThe effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo1734-19221896-915110.5114/aoms.2019.88625https://doaj.org/article/49bb105e40024e52b6944b544dcf4b952019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/The-effects-of-hyperbilirubinaemia-on-synaptic-plasticity-in-the-dentate-gyrus-region,76201,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of our study is to investigate the effect of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus (DG) region of the rat hippocampus. Material and methods Seven-day-old healthy Sprague Dawley (SD) rats were randomly divided into a control group and an experiment group (n = 20 in each group). The input/output (I/O) functions, paired-pulse reactions (PPR), excitatory postsynaptic potential (EPSP), and population spike (PS) amplitude were measured in the DG area of both groups of rats in response to stimulation applied to the lateral perforant path. Results Compared with that in the control rats, the current-voltage curves of both EPSP slope and PS amplitude in the experimental rats were significantly depressed. The average peak facilitation was 187 ±16% in the control and 164 ±18% in the experiment group (F = 21.054, p < 0.01). The facilitation period duration of PS was 155 ms in the experimental rats, which was less than that of the controls (235 ms). In the control group, the long-term potentiation (LTP) amplitudes were 140 ±3.5% and 242 ±6%, when estimated from the EPSP slope and PS amplitude, respectively, which were significantly depressed to 124 ±3.4% (EPSP slope, F = 70.489, p < 0.01) and 138 ±8.6% (PS amplitude, F = 253.46, p < 0.01), respectively, in the experiment group. Conclusions These findings suggest that hyperbilirubinaemia could induce impairment of synaptic plasticity in the rat DG area in vivo, including I/O function, paired-pulse ratio (PPR), and LTP, which may be closely related to cognitive impairment.Li YangDe WuBaotian WangXiaosong BuJing ZhuJiulai TangTermedia Publishing Housearticlehippocampushyperbilirubinemiasynaptic plasticitydentate gyrushyperbilirubinaemiaMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 200-204 (2019) |
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hippocampus hyperbilirubinemia synaptic plasticity dentate gyrus hyperbilirubinaemia Medicine R |
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hippocampus hyperbilirubinemia synaptic plasticity dentate gyrus hyperbilirubinaemia Medicine R Li Yang De Wu Baotian Wang Xiaosong Bu Jing Zhu Jiulai Tang The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo |
| description |
Introduction
The aim of our study is to investigate the effect of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus (DG) region of the rat hippocampus.
Material and methods
Seven-day-old healthy Sprague Dawley (SD) rats were randomly divided into a control group and an experiment group (n = 20 in each group). The input/output (I/O) functions, paired-pulse reactions (PPR), excitatory postsynaptic potential (EPSP), and population spike (PS) amplitude were measured in the DG area of both groups of rats in response to stimulation applied to the lateral perforant path.
Results
Compared with that in the control rats, the current-voltage curves of both EPSP slope and PS amplitude in the experimental rats were significantly depressed. The average peak facilitation was 187 ±16% in the control and 164 ±18% in the experiment group (F = 21.054, p < 0.01). The facilitation period duration of PS was 155 ms in the experimental rats, which was less than that of the controls (235 ms). In the control group, the long-term potentiation (LTP) amplitudes were 140 ±3.5% and 242 ±6%, when estimated from the EPSP slope and PS amplitude, respectively, which were significantly depressed to 124 ±3.4% (EPSP slope, F = 70.489, p < 0.01) and 138 ±8.6% (PS amplitude, F = 253.46, p < 0.01), respectively, in the experiment group.
Conclusions
These findings suggest that hyperbilirubinaemia could induce impairment of synaptic plasticity in the rat DG area in vivo, including I/O function, paired-pulse ratio (PPR), and LTP, which may be closely related to cognitive impairment. |
| format |
article |
| author |
Li Yang De Wu Baotian Wang Xiaosong Bu Jing Zhu Jiulai Tang |
| author_facet |
Li Yang De Wu Baotian Wang Xiaosong Bu Jing Zhu Jiulai Tang |
| author_sort |
Li Yang |
| title |
The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo |
| title_short |
The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo |
| title_full |
The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo |
| title_fullStr |
The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo |
| title_full_unstemmed |
The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo |
| title_sort |
effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo |
| publisher |
Termedia Publishing House |
| publishDate |
2019 |
| url |
https://doaj.org/article/49bb105e40024e52b6944b544dcf4b95 |
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