Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method

Gang Yang,* Zhe Li,* Feihua Wu, Minyan Chen, Rong Wang, Hao Zhu, Qin Li, Yongfang Yuan Department of Pharmacy, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China*These authors contributed equally to this w...

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Autores principales:	Yang G, Li Z, Wu F, Chen M, Wang R, Zhu H, Li Q, Yuan Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	greviscapine mesoporous silica nanoparticles supercritical carbon dioxide technology solubility bioavailability Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/49bba1a093304420bab70100954de43f
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spelling	oai:doaj.org-article:49bba1a093304420bab70100954de43f2021-12-02T09:15:11ZImproving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method1178-2013https://doaj.org/article/49bba1a093304420bab70100954de43f2020-03-01T00:00:00Zhttps://www.dovepress.com/improving-solubility-and-bioavailability-of-breviscapine-with-mesoporo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gang Yang,* Zhe Li,* Feihua Wu, Minyan Chen, Rong Wang, Hao Zhu, Qin Li, Yongfang Yuan Department of Pharmacy, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongfang YuanDepartment of Pharmacy, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of ChinaTel/Fax +86-21-56786907Email nmxyyf@126.comBackground: Breviscapine (BRE) has significant efficacy in cardiovascular disease, but the poor water solubility of breviscapine affects its oral absorption and limits its clinical application. In this study, supercritical carbon dioxide (SCF-CO2) technology was used to improve the solubility and bioavailability of BRE loaded into mesoporous silica nanoparticles (MSNs).Methods: The solubility of BRE in SCF-CO2 was measured under various conditions to investigate the feasibility of preparing drug-loaded MSNs by using ultrasound-assisted solution-enhanced dispersion by supercritical fluids (USEDS). The preparation process of drug-loaded MSNs was optimized using the central composite design (CCD), and the optimized preparation was comprehensively characterized. Furthermore, the drug-loaded MSNs prepared by the conventional method were compared. Finally, the dissolution and bioavailability of the preparations were evaluated by in vitro release and pharmacokinetics study.Results: The solubility of BRE in SCF-CO2 was extremely low which was suitable to prepare BRE-loaded MSNs by USEDS technology. The particle size of the preparation was 177.24 nm, the drug loading was 8.63%, and the specific surface area was 456.3m2/g. As compared to the conventional preparation method of solution impregnation-evaporation (SIV), the formulation prepared by USEDS technology has smaller particle size, higher drug loading, less residual solvent and better stability. The results of the in vitro release study showed that drug-loaded MSNs could significantly improve drug dissolution. The results of pharmacokinetics showed that the bioavailability of drug-loaded MSNs was increased 1.96 times compared to that of the BRE powder.Conclusion: Drug-loaded MSNs can significantly improve the solubility and bioavailability of BRE, indicating a good application prospect for MSNs in improving the oral absorption of drugs. In addition, as a solid dispersion preparation technology, USEDS technology has incomparable advantages.Keywords: greviscapine, mesoporous silica nanoparticles, supercritical carbon dioxide technology, solubility, bioavailabilityYang GLi ZWu FChen MWang RZhu HLi QYuan YDove Medical Pressarticlegreviscapinemesoporous silica nanoparticlessupercritical carbon dioxide technologysolubilitybioavailabilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 1661-1675 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	greviscapine mesoporous silica nanoparticles supercritical carbon dioxide technology solubility bioavailability Medicine (General) R5-920
spellingShingle	greviscapine mesoporous silica nanoparticles supercritical carbon dioxide technology solubility bioavailability Medicine (General) R5-920 Yang G Li Z Wu F Chen M Wang R Zhu H Li Q Yuan Y Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method
description	Gang Yang,* Zhe Li,* Feihua Wu, Minyan Chen, Rong Wang, Hao Zhu, Qin Li, Yongfang Yuan Department of Pharmacy, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongfang YuanDepartment of Pharmacy, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of ChinaTel/Fax +86-21-56786907Email nmxyyf@126.comBackground: Breviscapine (BRE) has significant efficacy in cardiovascular disease, but the poor water solubility of breviscapine affects its oral absorption and limits its clinical application. In this study, supercritical carbon dioxide (SCF-CO2) technology was used to improve the solubility and bioavailability of BRE loaded into mesoporous silica nanoparticles (MSNs).Methods: The solubility of BRE in SCF-CO2 was measured under various conditions to investigate the feasibility of preparing drug-loaded MSNs by using ultrasound-assisted solution-enhanced dispersion by supercritical fluids (USEDS). The preparation process of drug-loaded MSNs was optimized using the central composite design (CCD), and the optimized preparation was comprehensively characterized. Furthermore, the drug-loaded MSNs prepared by the conventional method were compared. Finally, the dissolution and bioavailability of the preparations were evaluated by in vitro release and pharmacokinetics study.Results: The solubility of BRE in SCF-CO2 was extremely low which was suitable to prepare BRE-loaded MSNs by USEDS technology. The particle size of the preparation was 177.24 nm, the drug loading was 8.63%, and the specific surface area was 456.3m2/g. As compared to the conventional preparation method of solution impregnation-evaporation (SIV), the formulation prepared by USEDS technology has smaller particle size, higher drug loading, less residual solvent and better stability. The results of the in vitro release study showed that drug-loaded MSNs could significantly improve drug dissolution. The results of pharmacokinetics showed that the bioavailability of drug-loaded MSNs was increased 1.96 times compared to that of the BRE powder.Conclusion: Drug-loaded MSNs can significantly improve the solubility and bioavailability of BRE, indicating a good application prospect for MSNs in improving the oral absorption of drugs. In addition, as a solid dispersion preparation technology, USEDS technology has incomparable advantages.Keywords: greviscapine, mesoporous silica nanoparticles, supercritical carbon dioxide technology, solubility, bioavailability
format	article
author	Yang G Li Z Wu F Chen M Wang R Zhu H Li Q Yuan Y
author_facet	Yang G Li Z Wu F Chen M Wang R Zhu H Li Q Yuan Y
author_sort	Yang G
title	Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method
title_short	Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method
title_full	Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method
title_fullStr	Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method
title_full_unstemmed	Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method
title_sort	improving solubility and bioavailability of breviscapine with mesoporous silica nanoparticles prepared using ultrasound-assisted solution-enhanced dispersion by supercritical fluids method
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/49bba1a093304420bab70100954de43f
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Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method

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