Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flow...

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Autores principales:	Yizi Zhang, Lingli Sun, Xingfei Lai, Xingjia Peng, Shuai Wen, Zhenbiao Zhang, Yinzheng Xie, Qiuhua Li, Ruohong Chen, Xi Zheng, Kun Zhang, Shili Sun, Dongli Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Inflammation Oxidative stress Gastrointestinal mucosal damage Apoptosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/49bd9fdc409f40018f80ec08dd5ebfa2
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spelling	oai:doaj.org-article:49bd9fdc409f40018f80ec08dd5ebfa22021-11-14T04:29:03ZGastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice0753-332210.1016/j.biopha.2021.112268https://doaj.org/article/49bd9fdc409f40018f80ec08dd5ebfa22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010520https://doaj.org/toc/0753-3322Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.Yizi ZhangLingli SunXingfei LaiXingjia PengShuai WenZhenbiao ZhangYinzheng XieQiuhua LiRuohong ChenXi ZhengKun ZhangShili SunDongli LiElsevierarticleInflammationOxidative stressGastrointestinal mucosal damageApoptosisTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112268- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Inflammation Oxidative stress Gastrointestinal mucosal damage Apoptosis Therapeutics. Pharmacology RM1-950
spellingShingle	Inflammation Oxidative stress Gastrointestinal mucosal damage Apoptosis Therapeutics. Pharmacology RM1-950 Yizi Zhang Lingli Sun Xingfei Lai Xingjia Peng Shuai Wen Zhenbiao Zhang Yinzheng Xie Qiuhua Li Ruohong Chen Xi Zheng Kun Zhang Shili Sun Dongli Li Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice
description	Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.
format	article
author	Yizi Zhang Lingli Sun Xingfei Lai Xingjia Peng Shuai Wen Zhenbiao Zhang Yinzheng Xie Qiuhua Li Ruohong Chen Xi Zheng Kun Zhang Shili Sun Dongli Li
author_facet	Yizi Zhang Lingli Sun Xingfei Lai Xingjia Peng Shuai Wen Zhenbiao Zhang Yinzheng Xie Qiuhua Li Ruohong Chen Xi Zheng Kun Zhang Shili Sun Dongli Li
author_sort	Yizi Zhang
title	Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice
title_short	Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice
title_full	Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice
title_fullStr	Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice
title_full_unstemmed	Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice
title_sort	gastroprotective effects of extract of jasminum grandiflorum l. flower in hcl/etoh-induced gastric mucosal ulceration mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/49bd9fdc409f40018f80ec08dd5ebfa2
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Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

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