Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.

<h4>Background</h4>Inflammation plays a key role in the pathogenesis of acute myocardial infarction (MI). However, it is unclear whether marker of immune activation will provide prognostic information in these patients. We hypothesized that circulating levels of soluble CD93 (sCD93), a s...

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Autores principales:	Jong-Chan Youn, Hee Tae Yu, Jae-Won Jeon, Hye Sun Lee, Yangsoo Jang, Young Woo Park, Yong-Beom Park, Eui-Cheol Shin, Jong-Won Ha
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49bff5c6376941ab9b0c5b3778e30a7e
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spelling	oai:doaj.org-article:49bff5c6376941ab9b0c5b3778e30a7e2021-11-18T08:20:36ZSoluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.1932-620310.1371/journal.pone.0096538https://doaj.org/article/49bff5c6376941ab9b0c5b3778e30a7e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24801400/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Inflammation plays a key role in the pathogenesis of acute myocardial infarction (MI). However, it is unclear whether marker of immune activation will provide prognostic information in these patients. We hypothesized that circulating levels of soluble CD93 (sCD93), a soluble form of transmembrane glycoprotein CD93, is increased in acute MI patients and its level would be associated with clinical outcomes in patients with acute MI.<h4>Methods</h4>We measured circulating levels of sCD93 in 120 patients with acute MI (63±13 yrs, M∶F = 85∶35) and in 120 age, sex-matched control subjects. In patients with acute MI, clinical characteristics, echocardiographic and laboratory findings were assessed at the time of initial enrollment. The primary outcome was defined as all-cause and cardiovascular death.<h4>Results</h4>Circulating sCD93 levels were significantly higher in patients with acute MI than in control subjects (552.1±293.7 vs. 429.8±114.2 ng/mL, p<0.0001). Upon in vitro inflammatory stimulation, increased CD93 shedding was demonstrated in acute MI patients but not in control subjects. During follow up period (median 208 days, 3-1058 days), the primary outcome occurred in 18 (15%) patients (9 cardiovascular deaths). Circulating levels of sCD93 were associated with all cause (p<0.0001) and cardiovascular (p<0.0001) mortality in patients with acute MI. Multivariate Cox regression analysis revealed that initial sCD93 level was found to be an independent predictor of all cause (p = 0.002) and cardiovascular mortality (p = 0.033) when controlled for age and left ventricular ejection fraction.<h4>Conclusions</h4>Circulating levels of sCD93 are elevated in patients with acute MI and their levels were associated with adverse clinical outcomes.Jong-Chan YounHee Tae YuJae-Won JeonHye Sun LeeYangsoo JangYoung Woo ParkYong-Beom ParkEui-Cheol ShinJong-Won HaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96538 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong-Chan Youn Hee Tae Yu Jae-Won Jeon Hye Sun Lee Yangsoo Jang Young Woo Park Yong-Beom Park Eui-Cheol Shin Jong-Won Ha Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
description	<h4>Background</h4>Inflammation plays a key role in the pathogenesis of acute myocardial infarction (MI). However, it is unclear whether marker of immune activation will provide prognostic information in these patients. We hypothesized that circulating levels of soluble CD93 (sCD93), a soluble form of transmembrane glycoprotein CD93, is increased in acute MI patients and its level would be associated with clinical outcomes in patients with acute MI.<h4>Methods</h4>We measured circulating levels of sCD93 in 120 patients with acute MI (63±13 yrs, M∶F = 85∶35) and in 120 age, sex-matched control subjects. In patients with acute MI, clinical characteristics, echocardiographic and laboratory findings were assessed at the time of initial enrollment. The primary outcome was defined as all-cause and cardiovascular death.<h4>Results</h4>Circulating sCD93 levels were significantly higher in patients with acute MI than in control subjects (552.1±293.7 vs. 429.8±114.2 ng/mL, p<0.0001). Upon in vitro inflammatory stimulation, increased CD93 shedding was demonstrated in acute MI patients but not in control subjects. During follow up period (median 208 days, 3-1058 days), the primary outcome occurred in 18 (15%) patients (9 cardiovascular deaths). Circulating levels of sCD93 were associated with all cause (p<0.0001) and cardiovascular (p<0.0001) mortality in patients with acute MI. Multivariate Cox regression analysis revealed that initial sCD93 level was found to be an independent predictor of all cause (p = 0.002) and cardiovascular mortality (p = 0.033) when controlled for age and left ventricular ejection fraction.<h4>Conclusions</h4>Circulating levels of sCD93 are elevated in patients with acute MI and their levels were associated with adverse clinical outcomes.
format	article
author	Jong-Chan Youn Hee Tae Yu Jae-Won Jeon Hye Sun Lee Yangsoo Jang Young Woo Park Yong-Beom Park Eui-Cheol Shin Jong-Won Ha
author_facet	Jong-Chan Youn Hee Tae Yu Jae-Won Jeon Hye Sun Lee Yangsoo Jang Young Woo Park Yong-Beom Park Eui-Cheol Shin Jong-Won Ha
author_sort	Jong-Chan Youn
title	Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
title_short	Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
title_full	Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
title_fullStr	Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
title_full_unstemmed	Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
title_sort	soluble cd93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/49bff5c6376941ab9b0c5b3778e30a7e
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Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.

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