IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.

<h4>Background</h4>Vaccines including conserved antigens from Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) have the potential to reduce the burden of acute otitis media. Little is known about the antibody response to such antigens in young children with recurren...

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Autores principales:	Selma P Wiertsema, Karli J Corscadden, Eva N Mowe, Guicheng Zhang, Shyan Vijayasekaran, Harvey L Coates, Timothy J Mitchell, Wayne R Thomas, Peter C Richmond, Lea-Ann S Kirkham
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49c3e2c5c7c64f2384f656f5c7a1bede
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spelling	oai:doaj.org-article:49c3e2c5c7c64f2384f656f5c7a1bede2021-11-18T08:09:07ZIgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.1932-620310.1371/journal.pone.0049061https://doaj.org/article/49c3e2c5c7c64f2384f656f5c7a1bede2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23152850/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Vaccines including conserved antigens from Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) have the potential to reduce the burden of acute otitis media. Little is known about the antibody response to such antigens in young children with recurrent acute otitis media, however, it has been suggested antibody production may be impaired in these children.<h4>Methods</h4>We measured serum IgG levels against 4 pneumococcal (PspA1, PspA 2, CbpA and Ply) and 3 NTHi (P4, P6 and PD) proteins in a cross-sectional study of 172 children under 3 years of age with a history of recurrent acute otitis media (median 7 episodes, requiring ventilation tube insertion) and 63 healthy age-matched controls, using a newly developed multiplex bead assay.<h4>Results</h4>Children with a history of recurrent acute otitis media had significantly higher geometric mean serum IgG levels against NTHi proteins P4, P6 and PD compared with healthy controls, whereas there was no difference in antibody levels against pneumococcal protein antigens. In both children with and without a history of acute otitis media, antibody levels increased with age and were significantly higher in children colonised with S. pneumoniae or NTHi compared with children that were not colonised.<h4>Conclusions</h4>Proteins from S. pneumoniae and NTHi induce serum IgG in children with a history of acute otitis media. The mechanisms in which proteins induce immunity and potential protection requires further investigation but the dogma of impaired antibody responses in children with recurrent acute otitis media should be reconsidered.Selma P WiertsemaKarli J CorscaddenEva N MoweGuicheng ZhangShyan VijayasekaranHarvey L CoatesTimothy J MitchellWayne R ThomasPeter C RichmondLea-Ann S KirkhamPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49061 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Selma P Wiertsema Karli J Corscadden Eva N Mowe Guicheng Zhang Shyan Vijayasekaran Harvey L Coates Timothy J Mitchell Wayne R Thomas Peter C Richmond Lea-Ann S Kirkham IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.
description	<h4>Background</h4>Vaccines including conserved antigens from Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) have the potential to reduce the burden of acute otitis media. Little is known about the antibody response to such antigens in young children with recurrent acute otitis media, however, it has been suggested antibody production may be impaired in these children.<h4>Methods</h4>We measured serum IgG levels against 4 pneumococcal (PspA1, PspA 2, CbpA and Ply) and 3 NTHi (P4, P6 and PD) proteins in a cross-sectional study of 172 children under 3 years of age with a history of recurrent acute otitis media (median 7 episodes, requiring ventilation tube insertion) and 63 healthy age-matched controls, using a newly developed multiplex bead assay.<h4>Results</h4>Children with a history of recurrent acute otitis media had significantly higher geometric mean serum IgG levels against NTHi proteins P4, P6 and PD compared with healthy controls, whereas there was no difference in antibody levels against pneumococcal protein antigens. In both children with and without a history of acute otitis media, antibody levels increased with age and were significantly higher in children colonised with S. pneumoniae or NTHi compared with children that were not colonised.<h4>Conclusions</h4>Proteins from S. pneumoniae and NTHi induce serum IgG in children with a history of acute otitis media. The mechanisms in which proteins induce immunity and potential protection requires further investigation but the dogma of impaired antibody responses in children with recurrent acute otitis media should be reconsidered.
format	article
author	Selma P Wiertsema Karli J Corscadden Eva N Mowe Guicheng Zhang Shyan Vijayasekaran Harvey L Coates Timothy J Mitchell Wayne R Thomas Peter C Richmond Lea-Ann S Kirkham
author_facet	Selma P Wiertsema Karli J Corscadden Eva N Mowe Guicheng Zhang Shyan Vijayasekaran Harvey L Coates Timothy J Mitchell Wayne R Thomas Peter C Richmond Lea-Ann S Kirkham
author_sort	Selma P Wiertsema
title	IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.
title_short	IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.
title_full	IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.
title_fullStr	IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.
title_full_unstemmed	IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.
title_sort	igg responses to pneumococcal and haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/49c3e2c5c7c64f2384f656f5c7a1bede
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IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.

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