PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding

A convenient method for the synthesis of the first generation PAMAM dendrimers based on the thiacalix[4]arene has been developed for the first time. Three new PAMAM-calix-dendrimers with the macrocyclic core in cone, partial cone, and 1,3-alternate</...

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Autores principales:	Olga Mostovaya, Pavel Padnya, Igor Shiabiev, Timur Mukhametzyanov, Ivan Stoikov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thiacalixarene DNA dendrimer PAMAM DNA binding DNA storage Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/49c46f9e3c714422b98b69240761c475
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spelling	oai:doaj.org-article:49c46f9e3c714422b98b69240761c4752021-11-11T17:18:59ZPAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding10.3390/ijms2221119011422-00671661-6596https://doaj.org/article/49c46f9e3c714422b98b69240761c4752021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11901https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067A convenient method for the synthesis of the first generation PAMAM dendrimers based on the thiacalix[4]arene has been developed for the first time. Three new PAMAM-calix-dendrimers with the macrocyclic core in <i>cone</i>, <i>partial cone</i>, and <i>1,3-alternate</i> conformations were obtained with high yields. The interaction of the obtained compounds with salmon sperm DNA resulted in the formation of the associates of the size up to 200 nm, as shown by the UV-Vis spectroscopy, DLS, and TEM. It was demonstrated by the CD method that the structure of the DNA did not undergo significant changes upon binding. The PAMAM-calix-dendrimer based on the macrocycle in <i>cone</i> conformation stabilized DNA and prevented its degradation.Olga MostovayaPavel PadnyaIgor ShiabievTimur MukhametzyanovIvan StoikovMDPI AGarticlethiacalixareneDNAdendrimerPAMAMDNA bindingDNA storageBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11901, p 11901 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thiacalixarene DNA dendrimer PAMAM DNA binding DNA storage Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	thiacalixarene DNA dendrimer PAMAM DNA binding DNA storage Biology (General) QH301-705.5 Chemistry QD1-999 Olga Mostovaya Pavel Padnya Igor Shiabiev Timur Mukhametzyanov Ivan Stoikov PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding
description	A convenient method for the synthesis of the first generation PAMAM dendrimers based on the thiacalix[4]arene has been developed for the first time. Three new PAMAM-calix-dendrimers with the macrocyclic core in <i>cone</i>, <i>partial cone</i>, and <i>1,3-alternate</i> conformations were obtained with high yields. The interaction of the obtained compounds with salmon sperm DNA resulted in the formation of the associates of the size up to 200 nm, as shown by the UV-Vis spectroscopy, DLS, and TEM. It was demonstrated by the CD method that the structure of the DNA did not undergo significant changes upon binding. The PAMAM-calix-dendrimer based on the macrocycle in <i>cone</i> conformation stabilized DNA and prevented its degradation.
format	article
author	Olga Mostovaya Pavel Padnya Igor Shiabiev Timur Mukhametzyanov Ivan Stoikov
author_facet	Olga Mostovaya Pavel Padnya Igor Shiabiev Timur Mukhametzyanov Ivan Stoikov
author_sort	Olga Mostovaya
title	PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding
title_short	PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding
title_full	PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding
title_fullStr	PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding
title_full_unstemmed	PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding
title_sort	pamam-calix-dendrimers: synthesis and thiacalixarene conformation effect on dna binding
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/49c46f9e3c714422b98b69240761c475
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PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding

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