Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC

The Legionella effector MavC catalyses the ubiquitination of the E2 enzyme UBE2N in the host cell through a transglutamination reaction, which can be inhibited by the Legionella effector Lpg2149. Here, the authors provide mechanistic insights into these processes by determining the crystal structure...

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Autores principales:	Yajuan Mu, Yue Wang, Yanfei Huang, Dong Li, Youyou Han, Min Chang, Jiaqi Fu, Yongchao Xie, Jie Ren, Hao Wang, Yi Zhang, Zhao-Qing Luo, Yue Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49c5000932d54e70b56ba771b5e61c22
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spelling	oai:doaj.org-article:49c5000932d54e70b56ba771b5e61c222021-12-02T14:40:29ZStructural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC10.1038/s41467-020-15645-72041-1723https://doaj.org/article/49c5000932d54e70b56ba771b5e61c222020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15645-7https://doaj.org/toc/2041-1723The Legionella effector MavC catalyses the ubiquitination of the E2 enzyme UBE2N in the host cell through a transglutamination reaction, which can be inhibited by the Legionella effector Lpg2149. Here, the authors provide mechanistic insights into these processes by determining the crystal structures of the MavC/UBE2N/Ub ternary complex, the MavC/UBE2N-Ub product complex and the MavC/Lpg2149 complex.Yajuan MuYue WangYanfei HuangDong LiYouyou HanMin ChangJiaqi FuYongchao XieJie RenHao WangYi ZhangZhao-Qing LuoYue FengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yajuan Mu Yue Wang Yanfei Huang Dong Li Youyou Han Min Chang Jiaqi Fu Yongchao Xie Jie Ren Hao Wang Yi Zhang Zhao-Qing Luo Yue Feng Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
description	The Legionella effector MavC catalyses the ubiquitination of the E2 enzyme UBE2N in the host cell through a transglutamination reaction, which can be inhibited by the Legionella effector Lpg2149. Here, the authors provide mechanistic insights into these processes by determining the crystal structures of the MavC/UBE2N/Ub ternary complex, the MavC/UBE2N-Ub product complex and the MavC/Lpg2149 complex.
format	article
author	Yajuan Mu Yue Wang Yanfei Huang Dong Li Youyou Han Min Chang Jiaqi Fu Yongchao Xie Jie Ren Hao Wang Yi Zhang Zhao-Qing Luo Yue Feng
author_facet	Yajuan Mu Yue Wang Yanfei Huang Dong Li Youyou Han Min Chang Jiaqi Fu Yongchao Xie Jie Ren Hao Wang Yi Zhang Zhao-Qing Luo Yue Feng
author_sort	Yajuan Mu
title	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
title_short	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
title_full	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
title_fullStr	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
title_full_unstemmed	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
title_sort	structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the legionella effector mavc
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/49c5000932d54e70b56ba771b5e61c22
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Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC

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