Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

Abstract To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strai...

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Autores principales:	D. S. Mansell, V. D. Bruno, E. Sammut, A. Chiribiri, T. Johnson, I. Khaliulin, D. Baz Lopez, H. S. Gill, K. H. Fraser, M. Murphy, T. Krieg, M. S. Suleiman, S. George, R. Ascione, A. N. Cookson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49c7bef0b6e94734a9fa2182672bbf80
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spelling	oai:doaj.org-article:49c7bef0b6e94734a9fa2182672bbf802021-12-02T18:34:01ZAcute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model10.1038/s41598-021-97834-y2045-2322https://doaj.org/article/49c7bef0b6e94734a9fa2182672bbf802021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97834-yhttps://doaj.org/toc/2045-2322Abstract To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.D. S. MansellV. D. BrunoE. SammutA. ChiribiriT. JohnsonI. KhaliulinD. Baz LopezH. S. GillK. H. FraserM. MurphyT. KriegM. S. SuleimanS. GeorgeR. AscioneA. N. CooksonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. S. Mansell V. D. Bruno E. Sammut A. Chiribiri T. Johnson I. Khaliulin D. Baz Lopez H. S. Gill K. H. Fraser M. Murphy T. Krieg M. S. Suleiman S. George R. Ascione A. N. Cookson Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
description	Abstract To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.
format	article
author	D. S. Mansell V. D. Bruno E. Sammut A. Chiribiri T. Johnson I. Khaliulin D. Baz Lopez H. S. Gill K. H. Fraser M. Murphy T. Krieg M. S. Suleiman S. George R. Ascione A. N. Cookson
author_facet	D. S. Mansell V. D. Bruno E. Sammut A. Chiribiri T. Johnson I. Khaliulin D. Baz Lopez H. S. Gill K. H. Fraser M. Murphy T. Krieg M. S. Suleiman S. George R. Ascione A. N. Cookson
author_sort	D. S. Mansell
title	Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
title_short	Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
title_full	Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
title_fullStr	Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
title_full_unstemmed	Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
title_sort	acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/49c7bef0b6e94734a9fa2182672bbf80
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Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

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