Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling

Abstract Currently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV...

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Autores principales:	Meina He, Dan Su, Qinghong Liu, Wenjuan Gao, Youmin Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49c9c1225f97426ba2b989572e6a610d
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spelling	oai:doaj.org-article:49c9c1225f97426ba2b989572e6a610d2021-12-02T16:06:25ZMushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling10.1038/s41598-017-06261-52045-2322https://doaj.org/article/49c9c1225f97426ba2b989572e6a610d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06261-5https://doaj.org/toc/2045-2322Abstract Currently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV infection therapy. Lectins from mushroom are natural and active proteins which have been shown important biological functions. However, little is known about the immunological mechanism engaged by mushroom lectins. Here we report that, lectin from Pleurotus ostreatus (POL) stimulated innate response by activating Toll-like receptor 6 signal pathway of dendritic cells. Subsequently POL enhanced HBV specific antibody level and follicular helper T cells response which overcame HBV tolerance in transgenic mice. This study suggests a novel mechanism for POL acting on immune response and a therapeutic approach to break HBV tolerance.Meina HeDan SuQinghong LiuWenjuan GaoYoumin KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meina He Dan Su Qinghong Liu Wenjuan Gao Youmin Kang Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
description	Abstract Currently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV infection therapy. Lectins from mushroom are natural and active proteins which have been shown important biological functions. However, little is known about the immunological mechanism engaged by mushroom lectins. Here we report that, lectin from Pleurotus ostreatus (POL) stimulated innate response by activating Toll-like receptor 6 signal pathway of dendritic cells. Subsequently POL enhanced HBV specific antibody level and follicular helper T cells response which overcame HBV tolerance in transgenic mice. This study suggests a novel mechanism for POL acting on immune response and a therapeutic approach to break HBV tolerance.
format	article
author	Meina He Dan Su Qinghong Liu Wenjuan Gao Youmin Kang
author_facet	Meina He Dan Su Qinghong Liu Wenjuan Gao Youmin Kang
author_sort	Meina He
title	Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_short	Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_full	Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_fullStr	Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_full_unstemmed	Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_sort	mushroom lectin overcomes hepatitis b virus tolerance via tlr6 signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/49c9c1225f97426ba2b989572e6a610d
work_keys_str_mv	AT meinahe mushroomlectinovercomeshepatitisbvirustoleranceviatlr6signaling AT dansu mushroomlectinovercomeshepatitisbvirustoleranceviatlr6signaling AT qinghongliu mushroomlectinovercomeshepatitisbvirustoleranceviatlr6signaling AT wenjuangao mushroomlectinovercomeshepatitisbvirustoleranceviatlr6signaling AT youminkang mushroomlectinovercomeshepatitisbvirustoleranceviatlr6signaling
_version_	1718385020745285632

Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling

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