Generation and trapping of a mesoderm biased state of human pluripotency

Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by identifying and trapping a mesoderm biased sub-s...

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Autores principales:	Dylan Stavish, Charlotta Böiers, Christopher Price, Thomas J. R. Frith, Jason Halliwell, Ingrid Saldaña-Guerrero, Jason Wray, John Brown, Jonathon Carr, Chela James, Ivana Barbaric, Peter W. Andrews, Tariq Enver
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49cf589d5cb741e6a087de76d2e33465
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spelling	oai:doaj.org-article:49cf589d5cb741e6a087de76d2e334652021-12-02T18:37:29ZGeneration and trapping of a mesoderm biased state of human pluripotency10.1038/s41467-020-18727-82041-1723https://doaj.org/article/49cf589d5cb741e6a087de76d2e334652020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18727-8https://doaj.org/toc/2041-1723Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by identifying and trapping a mesoderm biased sub-state in culture.Dylan StavishCharlotta BöiersChristopher PriceThomas J. R. FrithJason HalliwellIngrid Saldaña-GuerreroJason WrayJohn BrownJonathon CarrChela JamesIvana BarbaricPeter W. AndrewsTariq EnverNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dylan Stavish Charlotta Böiers Christopher Price Thomas J. R. Frith Jason Halliwell Ingrid Saldaña-Guerrero Jason Wray John Brown Jonathon Carr Chela James Ivana Barbaric Peter W. Andrews Tariq Enver Generation and trapping of a mesoderm biased state of human pluripotency
description	Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by identifying and trapping a mesoderm biased sub-state in culture.
format	article
author	Dylan Stavish Charlotta Böiers Christopher Price Thomas J. R. Frith Jason Halliwell Ingrid Saldaña-Guerrero Jason Wray John Brown Jonathon Carr Chela James Ivana Barbaric Peter W. Andrews Tariq Enver
author_facet	Dylan Stavish Charlotta Böiers Christopher Price Thomas J. R. Frith Jason Halliwell Ingrid Saldaña-Guerrero Jason Wray John Brown Jonathon Carr Chela James Ivana Barbaric Peter W. Andrews Tariq Enver
author_sort	Dylan Stavish
title	Generation and trapping of a mesoderm biased state of human pluripotency
title_short	Generation and trapping of a mesoderm biased state of human pluripotency
title_full	Generation and trapping of a mesoderm biased state of human pluripotency
title_fullStr	Generation and trapping of a mesoderm biased state of human pluripotency
title_full_unstemmed	Generation and trapping of a mesoderm biased state of human pluripotency
title_sort	generation and trapping of a mesoderm biased state of human pluripotency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/49cf589d5cb741e6a087de76d2e33465
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Generation and trapping of a mesoderm biased state of human pluripotency

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