Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

Abstract Liver and kidney diseases are becoming order of the day in both developed and developing countries as a result of environmental pollutants such as lead. Restorative activities of methanol and methanol/acetone phenolic-rich extracts (MPR and MAPR, respectively) of the N. latifolia fruit (NLF...

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Autores principales:	Musa Bola Busari, Rabiat Unekwu Hamzah, Hadiza Lami Muhammad, Ruqayyah Shehu Yusuf, Fatima Mohammad Madaki, Jamiu Olabanji Adeniyi, Yunusa Olatunji Ibrahim, Eustace Bonghan Berinyuy
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Nauclea latifolia Hepato-renal Toxicity Lead Antioxidant Phenolic-rich Medicine R Homeopathy RX1-681
Acceso en línea:	https://doaj.org/article/49cf9c0ba6954166bd7556e83e9ce7d6
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spelling	oai:doaj.org-article:49cf9c0ba6954166bd7556e83e9ce7d62021-11-21T12:27:05ZPhenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats10.1186/s40816-021-00322-z2199-1197https://doaj.org/article/49cf9c0ba6954166bd7556e83e9ce7d62021-11-01T00:00:00Zhttps://doi.org/10.1186/s40816-021-00322-zhttps://doaj.org/toc/2199-1197Abstract Liver and kidney diseases are becoming order of the day in both developed and developing countries as a result of environmental pollutants such as lead. Restorative activities of methanol and methanol/acetone phenolic-rich extracts (MPR and MAPR, respectively) of the N. latifolia fruit (NLF) on lead acetate-induced liver and kidney damaged were assessed in Wistar rats. The antioxidant activities of both phenolic-rich extracts of NLF were also carried out using standard methods. Seven groups of Wistar rats comprising of 5 rats each were used for the study and 1000 mg/kg body weight (bw.) of lead acetate solution was administered orally to the 6 groups of animals to induce liver and kidney damage. The high and low dosages of 300 and of 150 mg/kg body weight (bw.) of both MPR and MAPR were administered orally to four groups for 14 days along positive (100 mg/kg bw. of silymarin), negative (treated with the placebo) and naïve control (non-induced). The percentage DPPH radical scavenging activities, ferric reducing antioxidant power and percentage inhibition of lipid peroxidation show high antioxidants activities dose-dependently. Furthermore, administration of lead acetate significantly (p > 0.05) reduces the weight gain and elevates the liver and kidney relative weight as well as their respective damage biomarkers with distortions in their histologies. However, treatment with MPR and MAPR resulted in significant (p < 0.05) improve in the percentage body weight gain, relative liver and kidney weight as well as restoration of the activities of the liver and kidney functions biomarkers of the treated animals. Likewise, lesser hepatic and renal cells injury were also observed in the treated groups with MAPR being more active at high dosage which significantly (p < 0.05) compared well with normal group. Hence, the phenolics content of the N. latifolia fruit can be exploited further for drug development for the management kidney and liver damage arise from lead-induced toxicity.Musa Bola BusariRabiat Unekwu HamzahHadiza Lami MuhammadRuqayyah Shehu YusufFatima Mohammad MadakiJamiu Olabanji AdeniyiYunusa Olatunji IbrahimEustace Bonghan BerinyuySpringerOpenarticleNauclea latifoliaHepato-renalToxicityLeadAntioxidantPhenolic-richMedicineRHomeopathyRX1-681ENClinical Phytoscience, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nauclea latifolia Hepato-renal Toxicity Lead Antioxidant Phenolic-rich Medicine R Homeopathy RX1-681
spellingShingle	Nauclea latifolia Hepato-renal Toxicity Lead Antioxidant Phenolic-rich Medicine R Homeopathy RX1-681 Musa Bola Busari Rabiat Unekwu Hamzah Hadiza Lami Muhammad Ruqayyah Shehu Yusuf Fatima Mohammad Madaki Jamiu Olabanji Adeniyi Yunusa Olatunji Ibrahim Eustace Bonghan Berinyuy Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats
description	Abstract Liver and kidney diseases are becoming order of the day in both developed and developing countries as a result of environmental pollutants such as lead. Restorative activities of methanol and methanol/acetone phenolic-rich extracts (MPR and MAPR, respectively) of the N. latifolia fruit (NLF) on lead acetate-induced liver and kidney damaged were assessed in Wistar rats. The antioxidant activities of both phenolic-rich extracts of NLF were also carried out using standard methods. Seven groups of Wistar rats comprising of 5 rats each were used for the study and 1000 mg/kg body weight (bw.) of lead acetate solution was administered orally to the 6 groups of animals to induce liver and kidney damage. The high and low dosages of 300 and of 150 mg/kg body weight (bw.) of both MPR and MAPR were administered orally to four groups for 14 days along positive (100 mg/kg bw. of silymarin), negative (treated with the placebo) and naïve control (non-induced). The percentage DPPH radical scavenging activities, ferric reducing antioxidant power and percentage inhibition of lipid peroxidation show high antioxidants activities dose-dependently. Furthermore, administration of lead acetate significantly (p > 0.05) reduces the weight gain and elevates the liver and kidney relative weight as well as their respective damage biomarkers with distortions in their histologies. However, treatment with MPR and MAPR resulted in significant (p < 0.05) improve in the percentage body weight gain, relative liver and kidney weight as well as restoration of the activities of the liver and kidney functions biomarkers of the treated animals. Likewise, lesser hepatic and renal cells injury were also observed in the treated groups with MAPR being more active at high dosage which significantly (p < 0.05) compared well with normal group. Hence, the phenolics content of the N. latifolia fruit can be exploited further for drug development for the management kidney and liver damage arise from lead-induced toxicity.
format	article
author	Musa Bola Busari Rabiat Unekwu Hamzah Hadiza Lami Muhammad Ruqayyah Shehu Yusuf Fatima Mohammad Madaki Jamiu Olabanji Adeniyi Yunusa Olatunji Ibrahim Eustace Bonghan Berinyuy
author_facet	Musa Bola Busari Rabiat Unekwu Hamzah Hadiza Lami Muhammad Ruqayyah Shehu Yusuf Fatima Mohammad Madaki Jamiu Olabanji Adeniyi Yunusa Olatunji Ibrahim Eustace Bonghan Berinyuy
author_sort	Musa Bola Busari
title	Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats
title_short	Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats
title_full	Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats
title_fullStr	Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats
title_full_unstemmed	Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats
title_sort	phenolic rich-extracts from nauclea latifolia fruit restored lead acetate-induced liver and kidney damaged in wistar rats
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/49cf9c0ba6954166bd7556e83e9ce7d6
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Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

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