Molecular Preadaptation to Antimony Resistance in <named-content content-type="genus-species">Leishmania donovani</named-content> on the Indian Subcontinent

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Molecular Preadaptation to Antimony Resistance in <named-content content-type="genus-species">Leishmania donovani</named-content> on the Indian Subcontinent

ABSTRACT Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of Leishmania donovani resistance, this drug offers a unique model for understanding drug resistance dynamics. In a previous phylogenomic study, we...

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Auteurs principaux:	F. Dumetz, B. Cuypers, H. Imamura, D. Zander, E. D’Haenens, I. Maes, M. A. Domagalska, J. Clos, J.-C. Dujardin, G. De Muylder
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2018
Sujets:	Leishmania antimonials drug resistance mechanisms genomics metabolomics Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/49d1e1a7b21a47fe86a8b1efe9962b80
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