Does gender affect immune response in HIV patients?

Gender differences affect the frequency and course of many diseases. This study aimed to determine the gender distribution in HIV-infected patients and investigate the relationship between gender and immune response. The study included HIV-infected patients who followed up in our hospital in 2018. T...

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Autores principales:	Gulcin Sahingöz Erdal, Nilgun Isıksacan, Ramazan Korkusuz, Pınar Kasapoglu, Kadriye Kart Yasaroglu
Formato:	article
Lenguaje:	ID
Publicado:	Poltekkes Kemenkes Yogyakarta 2021
Materias:	hiv aids gender immune response Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/49d5830e1186402194b80a1d75667bfe
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spelling	oai:doaj.org-article:49d5830e1186402194b80a1d75667bfe2021-11-13T13:29:49ZDoes gender affect immune response in HIV patients?2338-56342580-019110.29238/teknolabjournal.v10i1.261https://doaj.org/article/49d5830e1186402194b80a1d75667bfe2021-08-01T00:00:00Zhttps://teknolabjournal.com/index.php/Jtl/article/view/261https://doaj.org/toc/2338-5634https://doaj.org/toc/2580-0191Gender differences affect the frequency and course of many diseases. This study aimed to determine the gender distribution in HIV-infected patients and investigate the relationship between gender and immune response. The study included HIV-infected patients who followed up in our hospital in 2018. The patients were divided into HIV RNA negative patients (Group 1) and HIV RNA positive patients (Group 2). Patients with diseases that may affect the immune system and those using drugs that affect the immune system were excluded from the study. The evaluation was made of 549 patients, as 305 patients (45 females 14.75%) in Group 1 and 224 patients (23 females, 9.43%) in Group 2. When the CD4/CD8 ratio of male and female patients was compared in both groups, a lower rate was determined in females (0.71-0.58) than males (0.82-0.93). A negative correlation was determined between HIV RNA and the CD4/CD8 ratio in premenopausal females (p=0.045) and males (≤45 years p=0.0001). Clinical studies of HIV infection have demonstrated better initial viremia control in females with primary infection, faster disease progression, and stronger immune activation than males for the same level of viral replication.Gulcin Sahingöz ErdalNilgun IsıksacanRamazan KorkusuzPınar KasapogluKadriye Kart YasarogluPoltekkes Kemenkes Yogyakartaarticlehivaidsgenderimmune responseMedicine (General)R5-920IDJurnal Teknologi Laboratorium, Vol 10, Iss 1, Pp 14-21 (2021)
institution	DOAJ
collection	DOAJ
language	ID
topic	hiv aids gender immune response Medicine (General) R5-920
spellingShingle	hiv aids gender immune response Medicine (General) R5-920 Gulcin Sahingöz Erdal Nilgun Isıksacan Ramazan Korkusuz Pınar Kasapoglu Kadriye Kart Yasaroglu Does gender affect immune response in HIV patients?
description	Gender differences affect the frequency and course of many diseases. This study aimed to determine the gender distribution in HIV-infected patients and investigate the relationship between gender and immune response. The study included HIV-infected patients who followed up in our hospital in 2018. The patients were divided into HIV RNA negative patients (Group 1) and HIV RNA positive patients (Group 2). Patients with diseases that may affect the immune system and those using drugs that affect the immune system were excluded from the study. The evaluation was made of 549 patients, as 305 patients (45 females 14.75%) in Group 1 and 224 patients (23 females, 9.43%) in Group 2. When the CD4/CD8 ratio of male and female patients was compared in both groups, a lower rate was determined in females (0.71-0.58) than males (0.82-0.93). A negative correlation was determined between HIV RNA and the CD4/CD8 ratio in premenopausal females (p=0.045) and males (≤45 years p=0.0001). Clinical studies of HIV infection have demonstrated better initial viremia control in females with primary infection, faster disease progression, and stronger immune activation than males for the same level of viral replication.
format	article
author	Gulcin Sahingöz Erdal Nilgun Isıksacan Ramazan Korkusuz Pınar Kasapoglu Kadriye Kart Yasaroglu
author_facet	Gulcin Sahingöz Erdal Nilgun Isıksacan Ramazan Korkusuz Pınar Kasapoglu Kadriye Kart Yasaroglu
author_sort	Gulcin Sahingöz Erdal
title	Does gender affect immune response in HIV patients?
title_short	Does gender affect immune response in HIV patients?
title_full	Does gender affect immune response in HIV patients?
title_fullStr	Does gender affect immune response in HIV patients?
title_full_unstemmed	Does gender affect immune response in HIV patients?
title_sort	does gender affect immune response in hiv patients?
publisher	Poltekkes Kemenkes Yogyakarta
publishDate	2021
url	https://doaj.org/article/49d5830e1186402194b80a1d75667bfe
work_keys_str_mv	AT gulcinsahingozerdal doesgenderaffectimmuneresponseinhivpatients AT nilgunisıksacan doesgenderaffectimmuneresponseinhivpatients AT ramazankorkusuz doesgenderaffectimmuneresponseinhivpatients AT pınarkasapoglu doesgenderaffectimmuneresponseinhivpatients AT kadriyekartyasaroglu doesgenderaffectimmuneresponseinhivpatients
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Does gender affect immune response in HIV patients?

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