The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration

Abstract Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migratio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jennifer Munkley, Urszula L. McClurg, Karen E. Livermore, Ingrid Ehrmann, Bridget Knight, Paul Mccullagh, John Mcgrath, Malcolm Crundwell, Lorna W. Harries, Hing Y. Leung, Ian G. Mills, Craig N. Robson, Prabhakar Rajan, David J. Elliott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49dff917c9574813aafb665056c1069f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:49dff917c9574813aafb665056c1069f
record_format	dspace
spelling	oai:doaj.org-article:49dff917c9574813aafb665056c1069f2021-12-02T11:40:14ZThe cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration10.1038/s41598-017-05489-52045-2322https://doaj.org/article/49dff917c9574813aafb665056c1069f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05489-5https://doaj.org/toc/2045-2322Abstract Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH). We also show for the first time, that TSPAN1 expression in prostate cancer cells controls the expression of key proteins involved in cell migration. Stable upregulation of TSPAN1 in both DU145 and PC3 cells significantly increased cell migration and induced the expression of the mesenchymal markers SLUG and ARF6. Our data suggest TSPAN1 is an androgen-driven contributor to cell survival and motility in prostate cancer.Jennifer MunkleyUrszula L. McClurgKaren E. LivermoreIngrid EhrmannBridget KnightPaul MccullaghJohn McgrathMalcolm CrundwellLorna W. HarriesHing Y. LeungIan G. MillsCraig N. RobsonPrabhakar RajanDavid J. ElliottNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer Munkley Urszula L. McClurg Karen E. Livermore Ingrid Ehrmann Bridget Knight Paul Mccullagh John Mcgrath Malcolm Crundwell Lorna W. Harries Hing Y. Leung Ian G. Mills Craig N. Robson Prabhakar Rajan David J. Elliott The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
description	Abstract Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH). We also show for the first time, that TSPAN1 expression in prostate cancer cells controls the expression of key proteins involved in cell migration. Stable upregulation of TSPAN1 in both DU145 and PC3 cells significantly increased cell migration and induced the expression of the mesenchymal markers SLUG and ARF6. Our data suggest TSPAN1 is an androgen-driven contributor to cell survival and motility in prostate cancer.
format	article
author	Jennifer Munkley Urszula L. McClurg Karen E. Livermore Ingrid Ehrmann Bridget Knight Paul Mccullagh John Mcgrath Malcolm Crundwell Lorna W. Harries Hing Y. Leung Ian G. Mills Craig N. Robson Prabhakar Rajan David J. Elliott
author_facet	Jennifer Munkley Urszula L. McClurg Karen E. Livermore Ingrid Ehrmann Bridget Knight Paul Mccullagh John Mcgrath Malcolm Crundwell Lorna W. Harries Hing Y. Leung Ian G. Mills Craig N. Robson Prabhakar Rajan David J. Elliott
author_sort	Jennifer Munkley
title	The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
title_short	The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
title_full	The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
title_fullStr	The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
title_full_unstemmed	The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
title_sort	cancer-associated cell migration protein tspan1 is under control of androgens and its upregulation increases prostate cancer cell migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/49dff917c9574813aafb665056c1069f
work_keys_str_mv	AT jennifermunkley thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT urszulalmcclurg thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT karenelivermore thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT ingridehrmann thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT bridgetknight thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT paulmccullagh thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT johnmcgrath thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT malcolmcrundwell thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT lornawharries thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT hingyleung thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT iangmills thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT craignrobson thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT prabhakarrajan thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT davidjelliott thecancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT jennifermunkley cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT urszulalmcclurg cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT karenelivermore cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT ingridehrmann cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT bridgetknight cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT paulmccullagh cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT johnmcgrath cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT malcolmcrundwell cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT lornawharries cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT hingyleung cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT iangmills cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT craignrobson cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT prabhakarrajan cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration AT davidjelliott cancerassociatedcellmigrationproteintspan1isundercontrolofandrogensanditsupregulationincreasesprostatecancercellmigration
_version_	1718395640098062336

The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration

Ejemplares similares