Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway

Abstract Acute myocardial infarction (MI) is one of the leading causes of death in humans. Our previous studies showed that gastrin alleviated acute myocardial ischaemia–reperfusion injury. We hypothesize that gastrin might protect against heart injury after MI by promoting angiogenesis. An MI model...

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Autores principales:	Rui Wang, Ziyue Zhang, Zaicheng Xu, Na Wang, Dezhong Yang, Zhi Zhao Liu, Qiao Liao, Xuewei Xia, Caiyu Chen, Jialing Shou, Liangpeng Li, Wei Eric Wang, Chunyu Zeng, Tianyang Xia, Hongyong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49e03515cf054553b50863cdd8f9180b
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spelling	oai:doaj.org-article:49e03515cf054553b50863cdd8f9180b2021-12-02T17:06:25ZGastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway10.1038/s41598-021-95110-72045-2322https://doaj.org/article/49e03515cf054553b50863cdd8f9180b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95110-7https://doaj.org/toc/2045-2322Abstract Acute myocardial infarction (MI) is one of the leading causes of death in humans. Our previous studies showed that gastrin alleviated acute myocardial ischaemia–reperfusion injury. We hypothesize that gastrin might protect against heart injury after MI by promoting angiogenesis. An MI model was simulated by ligating the anterior descending coronary artery in adult male C57BL/6J mice. Gastrin was administered twice daily by intraperitoneal injection for 2 weeks after MI. We found that gastrin reduced mortality, improved myocardial function with reduced infarct size and promoted angiogenesis. Gastrin increased HIF-1α and VEGF expression. Downregulation of HIF-1α expression by siRNA reduced the proliferation, migration and tube formation of human umbilical vein endothelial cells. These results indicate that gastrin restores cardiac function after MI by promoting angiogenesis via the HIF-1α/VEGF pathway.Rui WangZiyue ZhangZaicheng XuNa WangDezhong YangZhi Zhao LiuQiao LiaoXuewei XiaCaiyu ChenJialing ShouLiangpeng LiWei Eric WangChunyu ZengTianyang XiaHongyong WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rui Wang Ziyue Zhang Zaicheng Xu Na Wang Dezhong Yang Zhi Zhao Liu Qiao Liao Xuewei Xia Caiyu Chen Jialing Shou Liangpeng Li Wei Eric Wang Chunyu Zeng Tianyang Xia Hongyong Wang Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway
description	Abstract Acute myocardial infarction (MI) is one of the leading causes of death in humans. Our previous studies showed that gastrin alleviated acute myocardial ischaemia–reperfusion injury. We hypothesize that gastrin might protect against heart injury after MI by promoting angiogenesis. An MI model was simulated by ligating the anterior descending coronary artery in adult male C57BL/6J mice. Gastrin was administered twice daily by intraperitoneal injection for 2 weeks after MI. We found that gastrin reduced mortality, improved myocardial function with reduced infarct size and promoted angiogenesis. Gastrin increased HIF-1α and VEGF expression. Downregulation of HIF-1α expression by siRNA reduced the proliferation, migration and tube formation of human umbilical vein endothelial cells. These results indicate that gastrin restores cardiac function after MI by promoting angiogenesis via the HIF-1α/VEGF pathway.
format	article
author	Rui Wang Ziyue Zhang Zaicheng Xu Na Wang Dezhong Yang Zhi Zhao Liu Qiao Liao Xuewei Xia Caiyu Chen Jialing Shou Liangpeng Li Wei Eric Wang Chunyu Zeng Tianyang Xia Hongyong Wang
author_facet	Rui Wang Ziyue Zhang Zaicheng Xu Na Wang Dezhong Yang Zhi Zhao Liu Qiao Liao Xuewei Xia Caiyu Chen Jialing Shou Liangpeng Li Wei Eric Wang Chunyu Zeng Tianyang Xia Hongyong Wang
author_sort	Rui Wang
title	Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway
title_short	Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway
title_full	Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway
title_fullStr	Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway
title_full_unstemmed	Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway
title_sort	gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the hif-1α/vegf signalling pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/49e03515cf054553b50863cdd8f9180b
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Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway

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