Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats

Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway. This paper figured out the potential of oral and topical administration of C. asiatica extra...

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Autores principales:	Yeny Diah Rahmawati, Aulanni’am Aulanni’am, Sasangka Prasetyawan
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2019
Materias:	photoaging centella asiatica uvb tgf-β1 mmp-1 mda Chemistry QD1-999
Acceso en línea:	http://dx.doi.org/10.21776/ub.jpacr.2019.008.01.430 https://doaj.org/article/49eeefadc2224e418dbf9b37b74ecb76
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spelling	oai:doaj.org-article:49eeefadc2224e418dbf9b37b74ecb762021-12-02T18:08:38ZEffects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Ratshttp://dx.doi.org/10.21776/ub.jpacr.2019.008.01.4302302-46902302-4690https://doaj.org/article/49eeefadc2224e418dbf9b37b74ecb762019-01-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/430/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2302-4690Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway. This paper figured out the potential of oral and topical administration of C. asiatica extract on hairless rats skin tissue exposed by UVB based on expression of TGF-β1, MMP-1 and MDA dermis. A total of 30 male-hairless rats (Rattus novergicus) divided into 6 experimental groups, exposed by UVB with total dose 840 mJ/cm2 for four weeks. Topical gel therapy administered twice a day, 20 minutes before and 4 hours after irradiation. Oral therapy administered once a day before irradiation. Expression of TGF-β1, MMP-1 and MDA dermis observed by immunohistochemistry. The result showed that oral and topical therapy of C. asiatica extract was capable of inhibiting the increase of MMP-1 and MDA expression and the decrease of TGF- β1 significantly (p<0.05) in the dermal fibroblast of Wistar rat that exposed UVB light.Yeny Diah RahmawatiAulanni’am Aulanni’amSasangka PrasetyawanUniversity of Brawijayaarticlephotoagingcentella asiaticauvbtgf-β1mmp-1mdaChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 8, Iss 1, Pp 7-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	photoaging centella asiatica uvb tgf-β1 mmp-1 mda Chemistry QD1-999
spellingShingle	photoaging centella asiatica uvb tgf-β1 mmp-1 mda Chemistry QD1-999 Yeny Diah Rahmawati Aulanni’am Aulanni’am Sasangka Prasetyawan Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats
description	Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway. This paper figured out the potential of oral and topical administration of C. asiatica extract on hairless rats skin tissue exposed by UVB based on expression of TGF-β1, MMP-1 and MDA dermis. A total of 30 male-hairless rats (Rattus novergicus) divided into 6 experimental groups, exposed by UVB with total dose 840 mJ/cm2 for four weeks. Topical gel therapy administered twice a day, 20 minutes before and 4 hours after irradiation. Oral therapy administered once a day before irradiation. Expression of TGF-β1, MMP-1 and MDA dermis observed by immunohistochemistry. The result showed that oral and topical therapy of C. asiatica extract was capable of inhibiting the increase of MMP-1 and MDA expression and the decrease of TGF- β1 significantly (p<0.05) in the dermal fibroblast of Wistar rat that exposed UVB light.
format	article
author	Yeny Diah Rahmawati Aulanni’am Aulanni’am Sasangka Prasetyawan
author_facet	Yeny Diah Rahmawati Aulanni’am Aulanni’am Sasangka Prasetyawan
author_sort	Yeny Diah Rahmawati
title	Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats
title_short	Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats
title_full	Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats
title_fullStr	Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats
title_full_unstemmed	Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats
title_sort	effects of oral and topical application of centella asiatica extracts on the uvb-induced photoaging of hairless rats
publisher	University of Brawijaya
publishDate	2019
url	http://dx.doi.org/10.21776/ub.jpacr.2019.008.01.430 https://doaj.org/article/49eeefadc2224e418dbf9b37b74ecb76
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Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats

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