Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd

Transcription-repair coupling factors (TRCFs) are large ATPases that mediate the preferential repair of the transcribed DNA strand. Here the authors reveal the cryo-EM structure of DNA-bound Mfd, the bacterial TRCF, and provide molecular insights into its mode of action.

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Auteurs principaux:	Christiane Brugger, Cheng Zhang, Margaret M. Suhanovsky, David D. Kim, Amy N. Sinclair, Dmitry Lyumkis, Alexandra M. Deaconescu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/49f049022732482596be8740194b4dd5
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spelling	oai:doaj.org-article:49f049022732482596be8740194b4dd52021-12-02T16:31:53ZMolecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd10.1038/s41467-020-17457-12041-1723https://doaj.org/article/49f049022732482596be8740194b4dd52020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17457-1https://doaj.org/toc/2041-1723Transcription-repair coupling factors (TRCFs) are large ATPases that mediate the preferential repair of the transcribed DNA strand. Here the authors reveal the cryo-EM structure of DNA-bound Mfd, the bacterial TRCF, and provide molecular insights into its mode of action.Christiane BruggerCheng ZhangMargaret M. SuhanovskyDavid D. KimAmy N. SinclairDmitry LyumkisAlexandra M. DeaconescuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christiane Brugger Cheng Zhang Margaret M. Suhanovsky David D. Kim Amy N. Sinclair Dmitry Lyumkis Alexandra M. Deaconescu Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd
description	Transcription-repair coupling factors (TRCFs) are large ATPases that mediate the preferential repair of the transcribed DNA strand. Here the authors reveal the cryo-EM structure of DNA-bound Mfd, the bacterial TRCF, and provide molecular insights into its mode of action.
format	article
author	Christiane Brugger Cheng Zhang Margaret M. Suhanovsky David D. Kim Amy N. Sinclair Dmitry Lyumkis Alexandra M. Deaconescu
author_facet	Christiane Brugger Cheng Zhang Margaret M. Suhanovsky David D. Kim Amy N. Sinclair Dmitry Lyumkis Alexandra M. Deaconescu
author_sort	Christiane Brugger
title	Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd
title_short	Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd
title_full	Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd
title_fullStr	Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd
title_full_unstemmed	Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd
title_sort	molecular determinants for dsdna translocation by the transcription-repair coupling and evolvability factor mfd
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/49f049022732482596be8740194b4dd5
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Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd

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