Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

CRISPR-based knockout screens in cancer cells have suggested the existence of proliferation suppressor genes (PSG). Here, the authors develop an approach to systematically identify them, and reveal a PSG module involved in fatty acid synthesis and tumour suppression in acute myeloid leukemia cell li...

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Autores principales:	W. Frank Lenoir, Micaela Morgado, Peter C. DeWeirdt, Megan McLaughlin, Audrey L. Griffith, Annabel K. Sangree, Marissa N. Feeley, Nazanin Esmaeili Anvar, Eiru Kim, Lori L. Bertolet, Medina Colic, Merve Dede, John G. Doench, Traver Hart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49f1eb14cd9f49cb88919c70c04a8f5c
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spelling	oai:doaj.org-article:49f1eb14cd9f49cb88919c70c04a8f5c2021-11-14T12:35:53ZDiscovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells10.1038/s41467-021-26867-82041-1723https://doaj.org/article/49f1eb14cd9f49cb88919c70c04a8f5c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26867-8https://doaj.org/toc/2041-1723CRISPR-based knockout screens in cancer cells have suggested the existence of proliferation suppressor genes (PSG). Here, the authors develop an approach to systematically identify them, and reveal a PSG module involved in fatty acid synthesis and tumour suppression in acute myeloid leukemia cell lines.W. Frank LenoirMicaela MorgadoPeter C. DeWeirdtMegan McLaughlinAudrey L. GriffithAnnabel K. SangreeMarissa N. FeeleyNazanin Esmaeili AnvarEiru KimLori L. BertoletMedina ColicMerve DedeJohn G. DoenchTraver HartNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q W. Frank Lenoir Micaela Morgado Peter C. DeWeirdt Megan McLaughlin Audrey L. Griffith Annabel K. Sangree Marissa N. Feeley Nazanin Esmaeili Anvar Eiru Kim Lori L. Bertolet Medina Colic Merve Dede John G. Doench Traver Hart Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
description	CRISPR-based knockout screens in cancer cells have suggested the existence of proliferation suppressor genes (PSG). Here, the authors develop an approach to systematically identify them, and reveal a PSG module involved in fatty acid synthesis and tumour suppression in acute myeloid leukemia cell lines.
format	article
author	W. Frank Lenoir Micaela Morgado Peter C. DeWeirdt Megan McLaughlin Audrey L. Griffith Annabel K. Sangree Marissa N. Feeley Nazanin Esmaeili Anvar Eiru Kim Lori L. Bertolet Medina Colic Merve Dede John G. Doench Traver Hart
author_facet	W. Frank Lenoir Micaela Morgado Peter C. DeWeirdt Megan McLaughlin Audrey L. Griffith Annabel K. Sangree Marissa N. Feeley Nazanin Esmaeili Anvar Eiru Kim Lori L. Bertolet Medina Colic Merve Dede John G. Doench Traver Hart
author_sort	W. Frank Lenoir
title	Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
title_short	Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
title_full	Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
title_fullStr	Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
title_full_unstemmed	Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
title_sort	discovery of putative tumor suppressors from crispr screens reveals rewired lipid metabolism in acute myeloid leukemia cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/49f1eb14cd9f49cb88919c70c04a8f5c
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Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

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