Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake and cross-presentation by dendritic cells, thereby...

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Autores principales:	Evelyn Menares, Felipe Gálvez-Cancino, Pablo Cáceres-Morgado, Ehsan Ghorani, Ernesto López, Ximena Díaz, Juan Saavedra-Almarza, Diego A. Figueroa, Eduardo Roa, Sergio A. Quezada, Alvaro Lladser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49f2d80358fe4866a63b0347f802f6e7
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spelling	oai:doaj.org-article:49f2d80358fe4866a63b0347f802f6e72021-12-02T17:02:02ZTissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells10.1038/s41467-019-12319-x2041-1723https://doaj.org/article/49f2d80358fe4866a63b0347f802f6e72019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12319-xhttps://doaj.org/toc/2041-1723Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake and cross-presentation by dendritic cells, thereby eliciting de novo T cell responses.Evelyn MenaresFelipe Gálvez-CancinoPablo Cáceres-MorgadoEhsan GhoraniErnesto LópezXimena DíazJuan Saavedra-AlmarzaDiego A. FigueroaEduardo RoaSergio A. QuezadaAlvaro LladserNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evelyn Menares Felipe Gálvez-Cancino Pablo Cáceres-Morgado Ehsan Ghorani Ernesto López Ximena Díaz Juan Saavedra-Almarza Diego A. Figueroa Eduardo Roa Sergio A. Quezada Alvaro Lladser Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
description	Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake and cross-presentation by dendritic cells, thereby eliciting de novo T cell responses.
format	article
author	Evelyn Menares Felipe Gálvez-Cancino Pablo Cáceres-Morgado Ehsan Ghorani Ernesto López Ximena Díaz Juan Saavedra-Almarza Diego A. Figueroa Eduardo Roa Sergio A. Quezada Alvaro Lladser
author_facet	Evelyn Menares Felipe Gálvez-Cancino Pablo Cáceres-Morgado Ehsan Ghorani Ernesto López Ximena Díaz Juan Saavedra-Almarza Diego A. Figueroa Eduardo Roa Sergio A. Quezada Alvaro Lladser
author_sort	Evelyn Menares
title	Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
title_short	Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
title_full	Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
title_fullStr	Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
title_full_unstemmed	Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
title_sort	tissue-resident memory cd8+ t cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/49f2d80358fe4866a63b0347f802f6e7
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Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

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