Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.

<h4>Introduction</h4>In the last decade, survival of people living with HIV (PLHIV) has dramatically increased due wide availability of effective antiretroviral therapy. However, PLHIV remain at a comparatively higher risk of non-communicable comorbidities. We sought to determine the bur...

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Autores principales:	Ahmed Ddungu, Fred C Semitala, Barbara Castelnuovo, Christine Sekaggya-Wiltshire, William Worodria, Bruce J Kirenga
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49f45a572c6142c5be939598b1297a77
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spelling	oai:doaj.org-article:49f45a572c6142c5be939598b1297a772021-12-02T20:18:08ZChronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.1932-620310.1371/journal.pone.0256121https://doaj.org/article/49f45a572c6142c5be939598b1297a772021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256121https://doaj.org/toc/1932-6203<h4>Introduction</h4>In the last decade, survival of people living with HIV (PLHIV) has dramatically increased due wide availability of effective antiretroviral therapy. However, PLHIV remain at a comparatively higher risk of non-communicable comorbidities. We sought to determine the burden of COPD and its associations in an urban tertiary HIV clinic in Uganda.<h4>Methods and findings</h4>HIV-infected adults attending the Makerere University Joint AIDS program; aged ≥30 years without acute ailments were screened for COPD using study questionnaires and spirometry (post-bronchodilator FEV1/FVC<0.7). We determined its prevalence and association with demographic characteristics, body mass index (BMI) and known risk factors. Of 288 participants enrolled, 177 (61%) were female; 253 (88%) were from urban residences, median age was 45 years (IQR: 39-51), 71(25%) were 'ever' smokers, 284(99%) reported biomass fuel use and 72(25%) had a history of tuberculosis. All except 1 participant were on antiretroviral therapy, median current CD4 (cells/mm3) was 558 (IQR 402-753) and 275(96%) were virologically suppressed. Nearly half (130/288, 45%) had recurrent respiratory symptoms. The prevalence of COPD was 3.1% (9/288) [95% CI: 1.63-5.92]. COPD was associated with: previous tuberculosis, (adjusted odds ratio (AOR): 6.36, [95% CI 1.64-35.84], P = 0.036), self-reported chronic shortness of breath (AOR: 9.06, [95% CI 1.34-61.10], P = 0.024) and a BMI <21 Kg/m2 (AOR: 10.42 [95% CI: 1.61-100.00], P = 0.013).<h4>Conclusion</h4>In this HIV population, COPD prevalence was low and was associated with previous tuberculosis, self-reported chronic shortness of breath and BMI <21 Kg/m2.Ahmed DdunguFred C SemitalaBarbara CastelnuovoChristine Sekaggya-WiltshireWilliam WorodriaBruce J KirengaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256121 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ahmed Ddungu Fred C Semitala Barbara Castelnuovo Christine Sekaggya-Wiltshire William Worodria Bruce J Kirenga Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.
description	<h4>Introduction</h4>In the last decade, survival of people living with HIV (PLHIV) has dramatically increased due wide availability of effective antiretroviral therapy. However, PLHIV remain at a comparatively higher risk of non-communicable comorbidities. We sought to determine the burden of COPD and its associations in an urban tertiary HIV clinic in Uganda.<h4>Methods and findings</h4>HIV-infected adults attending the Makerere University Joint AIDS program; aged ≥30 years without acute ailments were screened for COPD using study questionnaires and spirometry (post-bronchodilator FEV1/FVC<0.7). We determined its prevalence and association with demographic characteristics, body mass index (BMI) and known risk factors. Of 288 participants enrolled, 177 (61%) were female; 253 (88%) were from urban residences, median age was 45 years (IQR: 39-51), 71(25%) were 'ever' smokers, 284(99%) reported biomass fuel use and 72(25%) had a history of tuberculosis. All except 1 participant were on antiretroviral therapy, median current CD4 (cells/mm3) was 558 (IQR 402-753) and 275(96%) were virologically suppressed. Nearly half (130/288, 45%) had recurrent respiratory symptoms. The prevalence of COPD was 3.1% (9/288) [95% CI: 1.63-5.92]. COPD was associated with: previous tuberculosis, (adjusted odds ratio (AOR): 6.36, [95% CI 1.64-35.84], P = 0.036), self-reported chronic shortness of breath (AOR: 9.06, [95% CI 1.34-61.10], P = 0.024) and a BMI <21 Kg/m2 (AOR: 10.42 [95% CI: 1.61-100.00], P = 0.013).<h4>Conclusion</h4>In this HIV population, COPD prevalence was low and was associated with previous tuberculosis, self-reported chronic shortness of breath and BMI <21 Kg/m2.
format	article
author	Ahmed Ddungu Fred C Semitala Barbara Castelnuovo Christine Sekaggya-Wiltshire William Worodria Bruce J Kirenga
author_facet	Ahmed Ddungu Fred C Semitala Barbara Castelnuovo Christine Sekaggya-Wiltshire William Worodria Bruce J Kirenga
author_sort	Ahmed Ddungu
title	Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.
title_short	Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.
title_full	Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.
title_fullStr	Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.
title_full_unstemmed	Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.
title_sort	chronic obstructive pulmonary disease prevalence and associated factors in an urban hiv clinic in a low income country.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/49f45a572c6142c5be939598b1297a77
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Chronic obstructive pulmonary disease prevalence and associated factors in an urban HIV clinic in a low income country.

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