Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach

Magnus Landgren,1,2 Salmir Nasic,3 Mats Johnson,1,2 Trygve Lövoll,1 Daniel Holmgren,4,5 Elisabeth Fernell2 1Department of Pediatrics, Unit of Developmental Disorders, Skaraborg’s Hospital, Mariestad, 2Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, 3Researc...

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Autores principales:	Landgren M, Nasic S, Johnson M, Lövoll T, Holmgren D, Fernell E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	AD/HD stimulant treatment blood pressure heart rate anthropometry long-term follow-up Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/49f9f5c7d6924909924195773dfd6e6c
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spelling	oai:doaj.org-article:49f9f5c7d6924909924195773dfd6e6c2021-12-02T01:51:49ZBlood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach1178-2021https://doaj.org/article/49f9f5c7d6924909924195773dfd6e6c2017-02-01T00:00:00Zhttps://www.dovepress.com/blood-pressure-and-anthropometry-in-children-treated-with-stimulants-a-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Magnus Landgren,1,2 Salmir Nasic,3 Mats Johnson,1,2 Trygve Lövoll,1 Daniel Holmgren,4,5 Elisabeth Fernell2 1Department of Pediatrics, Unit of Developmental Disorders, Skaraborg’s Hospital, Mariestad, 2Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, 3Research and Development Centre, 4Department of Pediatrics, Skaraborg’s Hospital, Skövde, 5University of Gothenburg, Gothenburg, Sweden Background: Knowledge about the long-term effects on blood pressure (BP) and body mass index (BMI) when treating young patients for attention-deficit/hyperactivity disorder (AD/HD) with stimulants is limited. Most of the studies have reported mean and not individual values for anthropometrics and BP in treatment with stimulants. This seems to be the first study of changes based on the analyses of individual data measured over time. Patients and methods: Seventy young patients (aged 8–18 years) diagnosed with AD/HD and responding well to treatment with stimulants were followed for a mean period of 3 years and 3 months. BP, heart rate, height, weight, and BMI were transformed to standard deviations or z-scores from before treatment to the last registered visit. Results: The mean dose of methylphenidate was 0.95 mg/kg. The mean increase of systolic and diastolic BP was 0.4 z-score and 0.1 z-score, respectively. The systolic BP was associated with BMI; a higher BMI at baseline increased the risk for an increase in systolic BP. Ten percent of the total group had a weight at follow-up of <-1.5 standard deviation (SD) and 12% had a height of <-1.5 SD. Mean height at follow-up was -0.2 SD, but 40% had a reduced height of at least 0.5 SD during the treatment period. BMI on a group level was reduced from +0.8 SD to +0.3 SD. Of the 19 patients with a BMI >+1.5 SD at baseline, 50% had a significantly reduced BMI. Conclusion: Consequences of stimulant treatment must be evaluated individually. Besides significant effects on core AD/HD symptoms, some patients have lower BMI and BP and some increase/maintain their BMI and/or increase their systolic BP. The risk of reduced height trajectory needs further research. Keywords: AD/HD, treatment, heart rate, long-term follow-up, methylphenidate, improvement, cardiovascular, overweight, height, BMI, healthLandgren MNasic SJohnson MLövoll THolmgren DFernell EDove Medical PressarticleAD/HDstimulant treatmentblood pressureheart rateanthropometrylong-term follow-upNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 499-506 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	AD/HD stimulant treatment blood pressure heart rate anthropometry long-term follow-up Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	AD/HD stimulant treatment blood pressure heart rate anthropometry long-term follow-up Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Landgren M Nasic S Johnson M Lövoll T Holmgren D Fernell E Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach
description	Magnus Landgren,1,2 Salmir Nasic,3 Mats Johnson,1,2 Trygve Lövoll,1 Daniel Holmgren,4,5 Elisabeth Fernell2 1Department of Pediatrics, Unit of Developmental Disorders, Skaraborg’s Hospital, Mariestad, 2Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, 3Research and Development Centre, 4Department of Pediatrics, Skaraborg’s Hospital, Skövde, 5University of Gothenburg, Gothenburg, Sweden Background: Knowledge about the long-term effects on blood pressure (BP) and body mass index (BMI) when treating young patients for attention-deficit/hyperactivity disorder (AD/HD) with stimulants is limited. Most of the studies have reported mean and not individual values for anthropometrics and BP in treatment with stimulants. This seems to be the first study of changes based on the analyses of individual data measured over time. Patients and methods: Seventy young patients (aged 8–18 years) diagnosed with AD/HD and responding well to treatment with stimulants were followed for a mean period of 3 years and 3 months. BP, heart rate, height, weight, and BMI were transformed to standard deviations or z-scores from before treatment to the last registered visit. Results: The mean dose of methylphenidate was 0.95 mg/kg. The mean increase of systolic and diastolic BP was 0.4 z-score and 0.1 z-score, respectively. The systolic BP was associated with BMI; a higher BMI at baseline increased the risk for an increase in systolic BP. Ten percent of the total group had a weight at follow-up of <-1.5 standard deviation (SD) and 12% had a height of <-1.5 SD. Mean height at follow-up was -0.2 SD, but 40% had a reduced height of at least 0.5 SD during the treatment period. BMI on a group level was reduced from +0.8 SD to +0.3 SD. Of the 19 patients with a BMI >+1.5 SD at baseline, 50% had a significantly reduced BMI. Conclusion: Consequences of stimulant treatment must be evaluated individually. Besides significant effects on core AD/HD symptoms, some patients have lower BMI and BP and some increase/maintain their BMI and/or increase their systolic BP. The risk of reduced height trajectory needs further research. Keywords: AD/HD, treatment, heart rate, long-term follow-up, methylphenidate, improvement, cardiovascular, overweight, height, BMI, health
format	article
author	Landgren M Nasic S Johnson M Lövoll T Holmgren D Fernell E
author_facet	Landgren M Nasic S Johnson M Lövoll T Holmgren D Fernell E
author_sort	Landgren M
title	Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach
title_short	Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach
title_full	Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach
title_fullStr	Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach
title_full_unstemmed	Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach
title_sort	blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/49f9f5c7d6924909924195773dfd6e6c
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Blood pressure and anthropometry in children treated with stimulants: a longitudinal cohort study with an individual approach

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