Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults

Fatema Al-Rashed,1 Sardar Sindhu,2 Ashraf Al Madhoun,2,3 Abdulwahab Alghaith,4 Rafaat Azim,1 Fahd Al-Mulla,3 Rasheed Ahmad1 1Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait; 2Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman, Kuwait; 3Genetics an...

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Autores principales:	Al-Rashed F, Sindhu S, Al Madhoun A, Alghaith A, Azim R, Al-Mulla F, Ahmad R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	sleep kuwait obesity psqi Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/49f9fa40ef284a1d963d3000e3e4c04a
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spelling	oai:doaj.org-article:49f9fa40ef284a1d963d3000e3e4c04a2021-12-02T17:55:05ZShort Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults1179-1608https://doaj.org/article/49f9fa40ef284a1d963d3000e3e4c04a2021-07-01T00:00:00Zhttps://www.dovepress.com/short-sleep-duration-and-its-association-with-obesity-and-other-metabo-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Fatema Al-Rashed,1 Sardar Sindhu,2 Ashraf Al Madhoun,2,3 Abdulwahab Alghaith,4 Rafaat Azim,1 Fahd Al-Mulla,3 Rasheed Ahmad1 1Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait; 2Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman, Kuwait; 3Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait; 4Royal College of Surgeons in Ireland, Dublin, IrelandCorrespondence: Fatema Al-Rashed; Rasheed AhmadMicrobiology & Immunology Department, Dasman Diabetes Institute, Al-Soor Street, Kuwait, P.O. Box 1180, Dasman, 15462, KuwaitTel +965 2224 2999 Ext. 4335; 4311Fax +965 2249 2406Email fatema.alrashed@dasmaninstitute.org; rasheed.ahmad@dasmaninstitute.orgBackground: Efficient sleep duration and its quality are increasingly recognized as important contributors for maintaining normal body weight. However, lifestyle and social structure within the Arab-gulf region differ compared to those in the western world. This study was specifically conducted in Kuwait’s population to investigate the link between sleep quality (SQ) and obesity in the absence of sleep apnea (SA) onset.Methods: SQ was measured by the Pittsburgh Sleep Quality Index (PQSI) in 984 participants, then verified in 60 individuals including 20 lean (Body mass index/BMI: 18.5– 24.9 kg/m2), 20 overweight (BMI: 25– 29.9 kg/m2) and 20 obese (BMI: ≥ 30 kg/m2) through actigraph worn over the right-hip for 7 consecutive days to characterize their sleep–wake cycle, rest-activity, and physical activity. Blood samples were collected for metabolic markers.Results: 59.6% of participants reported a PSQI score higher than 5, with 57.6% of the participants reporting less than 6 hours of sleep per day. The data show that both SQ and sleep duration are considered inadequate in comparison to the international SQ standards. We found a significant association between SQ and obesity independent of age and sex. Actigraph data further supported the independent association of sleep duration on BMI within the population (p < 0.001). Additionally, total sleep time (TST) was found to significantly correlate with several other metabolic factors including diastolic blood pressure, elevated resting heart rate (RHR), triglycerides, total cholesterol, homeostatic model assessment for insulin resistance (HOMA-IR), C-peptide, and C-Reactive Protein (CRP) secretion. Further multiple-regression analysis showed a significant independent association between blood pressure (p < 0.03), HOMA-IR (p < 0.04), and C-peptide (p < 0.3) and sleep duration.Conclusion: These findings suggest that sleep deprivation and disturbance could be indirect factors involved in the development of not only obesity in Kuwait but also other metabolic syndromes such as type 2 diabetes.Keywords: sleep, Kuwait, obesity, PSQIAl-Rashed FSindhu SAl Madhoun AAlghaith AAzim RAl-Mulla FAhmad RDove Medical PressarticlesleepkuwaitobesitypsqiPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1225-1241 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep kuwait obesity psqi Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	sleep kuwait obesity psqi Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Al-Rashed F Sindhu S Al Madhoun A Alghaith A Azim R Al-Mulla F Ahmad R Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults
description	Fatema Al-Rashed,1 Sardar Sindhu,2 Ashraf Al Madhoun,2,3 Abdulwahab Alghaith,4 Rafaat Azim,1 Fahd Al-Mulla,3 Rasheed Ahmad1 1Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait; 2Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman, Kuwait; 3Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait; 4Royal College of Surgeons in Ireland, Dublin, IrelandCorrespondence: Fatema Al-Rashed; Rasheed AhmadMicrobiology & Immunology Department, Dasman Diabetes Institute, Al-Soor Street, Kuwait, P.O. Box 1180, Dasman, 15462, KuwaitTel +965 2224 2999 Ext. 4335; 4311Fax +965 2249 2406Email fatema.alrashed@dasmaninstitute.org; rasheed.ahmad@dasmaninstitute.orgBackground: Efficient sleep duration and its quality are increasingly recognized as important contributors for maintaining normal body weight. However, lifestyle and social structure within the Arab-gulf region differ compared to those in the western world. This study was specifically conducted in Kuwait’s population to investigate the link between sleep quality (SQ) and obesity in the absence of sleep apnea (SA) onset.Methods: SQ was measured by the Pittsburgh Sleep Quality Index (PQSI) in 984 participants, then verified in 60 individuals including 20 lean (Body mass index/BMI: 18.5– 24.9 kg/m2), 20 overweight (BMI: 25– 29.9 kg/m2) and 20 obese (BMI: ≥ 30 kg/m2) through actigraph worn over the right-hip for 7 consecutive days to characterize their sleep–wake cycle, rest-activity, and physical activity. Blood samples were collected for metabolic markers.Results: 59.6% of participants reported a PSQI score higher than 5, with 57.6% of the participants reporting less than 6 hours of sleep per day. The data show that both SQ and sleep duration are considered inadequate in comparison to the international SQ standards. We found a significant association between SQ and obesity independent of age and sex. Actigraph data further supported the independent association of sleep duration on BMI within the population (p < 0.001). Additionally, total sleep time (TST) was found to significantly correlate with several other metabolic factors including diastolic blood pressure, elevated resting heart rate (RHR), triglycerides, total cholesterol, homeostatic model assessment for insulin resistance (HOMA-IR), C-peptide, and C-Reactive Protein (CRP) secretion. Further multiple-regression analysis showed a significant independent association between blood pressure (p < 0.03), HOMA-IR (p < 0.04), and C-peptide (p < 0.3) and sleep duration.Conclusion: These findings suggest that sleep deprivation and disturbance could be indirect factors involved in the development of not only obesity in Kuwait but also other metabolic syndromes such as type 2 diabetes.Keywords: sleep, Kuwait, obesity, PSQI
format	article
author	Al-Rashed F Sindhu S Al Madhoun A Alghaith A Azim R Al-Mulla F Ahmad R
author_facet	Al-Rashed F Sindhu S Al Madhoun A Alghaith A Azim R Al-Mulla F Ahmad R
author_sort	Al-Rashed F
title	Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults
title_short	Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults
title_full	Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults
title_fullStr	Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults
title_full_unstemmed	Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults
title_sort	short sleep duration and its association with obesity and other metabolic risk factors in kuwaiti urban adults
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/49f9fa40ef284a1d963d3000e3e4c04a
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Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults

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