Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.

Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link betwee...

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Autores principales:	Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Song
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49fabf64f1c44863a725dd200c8f12ac
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spelling	oai:doaj.org-article:49fabf64f1c44863a725dd200c8f12ac2021-12-02T20:10:39ZTooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.1932-620310.1371/journal.pone.0253257https://doaj.org/article/49fabf64f1c44863a725dd200c8f12ac2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253257https://doaj.org/toc/1932-6203Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link between tooth loss and the risk of hypertension. From the national health insurance system-health screening cohort in Korea, 19,680 participants who underwent three or more health examinations, including blood pressure measurements, between January 2003 and December 2008, without any history or diagnosis of hypertension were included in this study. Hypertension was defined as the diagnosis of hypertension (International Classification of Diseases-10 code "I10-11") accompanied by the prescription of an antihypertensive agent or at least one health examination result of blood pressure of ≥140/90 mmHg. Kaplan-Meier survival curves with the log-rank test were used to evaluate the relationship between oral hygiene indicators and the incidence of hypertension. Cox proportional hazard models were applied to determine the association between oral hygiene indicators and the development of hypertension. During a median follow-up of 7.4 years, 1,853 patients developed hypertension. The estimated incidence of hypertension within seven years was 8.8%. Multivariable analysis confirmed a significant relationship between the number of lost teeth and hypertension (hazard ratio: 2.26; 95% confidence interval [1.24-4.10], p = 0.007, p for trend = 0.005). There was a positive association between the number of lost teeth and the risk of hypertension in a longitudinal research. In conclusion, the number of lost teeth may be associated with the risk of development of hypertension.Ho Geol WooYoonkyung ChangJi Sung LeeTae-Jin SongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253257 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ho Geol Woo Yoonkyung Chang Ji Sung Lee Tae-Jin Song Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.
description	Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. The aim of this study was to investigate the link between tooth loss and the risk of hypertension. From the national health insurance system-health screening cohort in Korea, 19,680 participants who underwent three or more health examinations, including blood pressure measurements, between January 2003 and December 2008, without any history or diagnosis of hypertension were included in this study. Hypertension was defined as the diagnosis of hypertension (International Classification of Diseases-10 code "I10-11") accompanied by the prescription of an antihypertensive agent or at least one health examination result of blood pressure of ≥140/90 mmHg. Kaplan-Meier survival curves with the log-rank test were used to evaluate the relationship between oral hygiene indicators and the incidence of hypertension. Cox proportional hazard models were applied to determine the association between oral hygiene indicators and the development of hypertension. During a median follow-up of 7.4 years, 1,853 patients developed hypertension. The estimated incidence of hypertension within seven years was 8.8%. Multivariable analysis confirmed a significant relationship between the number of lost teeth and hypertension (hazard ratio: 2.26; 95% confidence interval [1.24-4.10], p = 0.007, p for trend = 0.005). There was a positive association between the number of lost teeth and the risk of hypertension in a longitudinal research. In conclusion, the number of lost teeth may be associated with the risk of development of hypertension.
format	article
author	Ho Geol Woo Yoonkyung Chang Ji Sung Lee Tae-Jin Song
author_facet	Ho Geol Woo Yoonkyung Chang Ji Sung Lee Tae-Jin Song
author_sort	Ho Geol Woo
title	Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.
title_short	Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.
title_full	Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.
title_fullStr	Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.
title_full_unstemmed	Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.
title_sort	tooth loss is associated with an increased risk of hypertension: a nationwide population-based cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/49fabf64f1c44863a725dd200c8f12ac
work_keys_str_mv	AT hogeolwoo toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy AT yoonkyungchang toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy AT jisunglee toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy AT taejinsong toothlossisassociatedwithanincreasedriskofhypertensionanationwidepopulationbasedcohortstudy
_version_	1718374942779637760

Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.

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