An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli

This study demonstrated the effect of positional isomerism of benzoic acid derivatives against E. coli ATCC 700728 with the serotype O157. The addition of hydroxyl and methoxyl substituents weakened the effect of acids against E. coli with respect to benzoic acid (except 2-hydroxybenzoic). The conne...

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Autores principales:	Synowiec Alicja, Żyła Kinga, Gniewosz Małgorzata, Kieliszek Marek
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	benzoic acid derivatives positional isomerism antibacterial activity e. coli Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/49fb21ff1b4d494bb84f0125a2633ca4
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spelling	oai:doaj.org-article:49fb21ff1b4d494bb84f0125a2633ca42021-12-05T14:10:41ZAn effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli2391-541210.1515/biol-2021-0060https://doaj.org/article/49fb21ff1b4d494bb84f0125a2633ca42021-06-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0060https://doaj.org/toc/2391-5412This study demonstrated the effect of positional isomerism of benzoic acid derivatives against E. coli ATCC 700728 with the serotype O157. The addition of hydroxyl and methoxyl substituents weakened the effect of acids against E. coli with respect to benzoic acid (except 2-hydroxybenzoic). The connection of the hydroxyl group at the second carbon atom in the benzoic ring reduced the time needed to kill bacterial cells. Phenolic acids with methoxyl substitutes limited the biofilm formation by E. coli to a greater extent than hydroxyl derivatives. The most significant influence on the antibacterial activity of phenolic acids has the type of substituent attached to the benzoic ring, their number, and finally the number of carbon atoms at which the functional group is located.Synowiec AlicjaŻyła KingaGniewosz MałgorzataKieliszek MarekDe Gruyterarticlebenzoic acid derivativespositional isomerismantibacterial activitye. coliBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 594-601 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	benzoic acid derivatives positional isomerism antibacterial activity e. coli Biology (General) QH301-705.5
spellingShingle	benzoic acid derivatives positional isomerism antibacterial activity e. coli Biology (General) QH301-705.5 Synowiec Alicja Żyła Kinga Gniewosz Małgorzata Kieliszek Marek An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
description	This study demonstrated the effect of positional isomerism of benzoic acid derivatives against E. coli ATCC 700728 with the serotype O157. The addition of hydroxyl and methoxyl substituents weakened the effect of acids against E. coli with respect to benzoic acid (except 2-hydroxybenzoic). The connection of the hydroxyl group at the second carbon atom in the benzoic ring reduced the time needed to kill bacterial cells. Phenolic acids with methoxyl substitutes limited the biofilm formation by E. coli to a greater extent than hydroxyl derivatives. The most significant influence on the antibacterial activity of phenolic acids has the type of substituent attached to the benzoic ring, their number, and finally the number of carbon atoms at which the functional group is located.
format	article
author	Synowiec Alicja Żyła Kinga Gniewosz Małgorzata Kieliszek Marek
author_facet	Synowiec Alicja Żyła Kinga Gniewosz Małgorzata Kieliszek Marek
author_sort	Synowiec Alicja
title	An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
title_short	An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
title_full	An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
title_fullStr	An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
title_full_unstemmed	An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
title_sort	effect of positional isomerism of benzoic acid derivatives on antibacterial activity against escherichia coli
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/49fb21ff1b4d494bb84f0125a2633ca4
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An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli

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