Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

The NALCN channel mediates sodium leak currents, which in turn adjusts resting membrane potential and neuronal excitability. Here the authors describe a cryo-EM structure of mammalian NALCN-FAM155A channel complex, showing how selectivity filter contributes to sodium permeation and calcium block and...

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Autores principales:	Yunlu Kang, Jing-Xiang Wu, Lei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a01fb3b9eac4a6eaaf11895ad50315c
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spelling	oai:doaj.org-article:4a01fb3b9eac4a6eaaf11895ad50315c2021-12-02T16:56:32ZStructure of voltage-modulated sodium-selective NALCN-FAM155A channel complex10.1038/s41467-020-20002-92041-1723https://doaj.org/article/4a01fb3b9eac4a6eaaf11895ad50315c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20002-9https://doaj.org/toc/2041-1723The NALCN channel mediates sodium leak currents, which in turn adjusts resting membrane potential and neuronal excitability. Here the authors describe a cryo-EM structure of mammalian NALCN-FAM155A channel complex, showing how selectivity filter contributes to sodium permeation and calcium block and how the voltage sensors contribute to current modulation.Yunlu KangJing-Xiang WuLei ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunlu Kang Jing-Xiang Wu Lei Chen Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
description	The NALCN channel mediates sodium leak currents, which in turn adjusts resting membrane potential and neuronal excitability. Here the authors describe a cryo-EM structure of mammalian NALCN-FAM155A channel complex, showing how selectivity filter contributes to sodium permeation and calcium block and how the voltage sensors contribute to current modulation.
format	article
author	Yunlu Kang Jing-Xiang Wu Lei Chen
author_facet	Yunlu Kang Jing-Xiang Wu Lei Chen
author_sort	Yunlu Kang
title	Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
title_short	Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
title_full	Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
title_fullStr	Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
title_full_unstemmed	Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
title_sort	structure of voltage-modulated sodium-selective nalcn-fam155a channel complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4a01fb3b9eac4a6eaaf11895ad50315c
work_keys_str_mv	AT yunlukang structureofvoltagemodulatedsodiumselectivenalcnfam155achannelcomplex AT jingxiangwu structureofvoltagemodulatedsodiumselectivenalcnfam155achannelcomplex AT leichen structureofvoltagemodulatedsodiumselectivenalcnfam155achannelcomplex
_version_	1718382797676085248

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

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