Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality. Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatmen...
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Al-Azhar University, Faculty of Medicine (Damietta)
2021
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oai:doaj.org-article:4a03317c7cab4c72866ae8953e3b63b12021-12-02T15:42:54ZComparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo2636-41742682-378010.21608/ijma.2021.48137.1205https://doaj.org/article/4a03317c7cab4c72866ae8953e3b63b12021-04-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_142495_ef2615a2d265f2b09c6b24496b3cd15d.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality. Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo, Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented. Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimus-treated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA. Conclusion: The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo. However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus.Rofaida ElnokalyOsama SayedAhmedHassan MohamedAl-Azhar University, Faculty of Medicine (Damietta)articlevitiligoresponsemicroneedlingtacrolimustcaMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 2, Pp 1188-1194 (2021) |
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vitiligo response microneedling tacrolimus tca Medicine (General) R5-920 |
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vitiligo response microneedling tacrolimus tca Medicine (General) R5-920 Rofaida Elnokaly Osama SayedAhmed Hassan Mohamed Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo |
description |
Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality. Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo, Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented. Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimus-treated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA. Conclusion: The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo. However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus. |
format |
article |
author |
Rofaida Elnokaly Osama SayedAhmed Hassan Mohamed |
author_facet |
Rofaida Elnokaly Osama SayedAhmed Hassan Mohamed |
author_sort |
Rofaida Elnokaly |
title |
Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo |
title_short |
Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo |
title_full |
Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo |
title_fullStr |
Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo |
title_full_unstemmed |
Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo |
title_sort |
comparative study between the efficacy of microneedling combined with trichloroacetic acid versus microneedling with tacrolimus in the treatment of stable vitiligo |
publisher |
Al-Azhar University, Faculty of Medicine (Damietta) |
publishDate |
2021 |
url |
https://doaj.org/article/4a03317c7cab4c72866ae8953e3b63b1 |
work_keys_str_mv |
AT rofaidaelnokaly comparativestudybetweentheefficacyofmicroneedlingcombinedwithtrichloroaceticacidversusmicroneedlingwithtacrolimusinthetreatmentofstablevitiligo AT osamasayedahmed comparativestudybetweentheefficacyofmicroneedlingcombinedwithtrichloroaceticacidversusmicroneedlingwithtacrolimusinthetreatmentofstablevitiligo AT hassanmohamed comparativestudybetweentheefficacyofmicroneedlingcombinedwithtrichloroaceticacidversusmicroneedlingwithtacrolimusinthetreatmentofstablevitiligo |
_version_ |
1718385805623296000 |