Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo

Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality.   Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatmen...

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Autores principales: Rofaida Elnokaly, Osama SayedAhmed, Hassan Mohamed
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Lenguaje:EN
Publicado: Al-Azhar University, Faculty of Medicine (Damietta) 2021
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spelling oai:doaj.org-article:4a03317c7cab4c72866ae8953e3b63b12021-12-02T15:42:54ZComparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo2636-41742682-378010.21608/ijma.2021.48137.1205https://doaj.org/article/4a03317c7cab4c72866ae8953e3b63b12021-04-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_142495_ef2615a2d265f2b09c6b24496b3cd15d.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality.   Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo, Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented.   Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimus-treated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA. Conclusion: The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo. However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus.Rofaida ElnokalyOsama SayedAhmedHassan MohamedAl-Azhar University, Faculty of Medicine (Damietta)articlevitiligoresponsemicroneedlingtacrolimustcaMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 2, Pp 1188-1194 (2021)
institution DOAJ
collection DOAJ
language EN
topic vitiligo
response
microneedling
tacrolimus
tca
Medicine (General)
R5-920
spellingShingle vitiligo
response
microneedling
tacrolimus
tca
Medicine (General)
R5-920
Rofaida Elnokaly
Osama SayedAhmed
Hassan Mohamed
Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
description Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality.   Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo, Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented.   Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimus-treated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA. Conclusion: The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo. However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus.
format article
author Rofaida Elnokaly
Osama SayedAhmed
Hassan Mohamed
author_facet Rofaida Elnokaly
Osama SayedAhmed
Hassan Mohamed
author_sort Rofaida Elnokaly
title Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_short Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_full Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_fullStr Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_full_unstemmed Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_sort comparative study between the efficacy of microneedling combined with trichloroacetic acid versus microneedling with tacrolimus in the treatment of stable vitiligo
publisher Al-Azhar University, Faculty of Medicine (Damietta)
publishDate 2021
url https://doaj.org/article/4a03317c7cab4c72866ae8953e3b63b1
work_keys_str_mv AT rofaidaelnokaly comparativestudybetweentheefficacyofmicroneedlingcombinedwithtrichloroaceticacidversusmicroneedlingwithtacrolimusinthetreatmentofstablevitiligo
AT osamasayedahmed comparativestudybetweentheefficacyofmicroneedlingcombinedwithtrichloroaceticacidversusmicroneedlingwithtacrolimusinthetreatmentofstablevitiligo
AT hassanmohamed comparativestudybetweentheefficacyofmicroneedlingcombinedwithtrichloroaceticacidversusmicroneedlingwithtacrolimusinthetreatmentofstablevitiligo
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