Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver

The hepatocyte nuclear factor-4α (HNF4α) and hepatocyte nuclear factor-1α (HNF1α) are transcription factors that influence the development and maintenance of homeostasis in a variety of tissues, including the liver. As such, disruptions in their transcriptional networks can herald a number of pathol...

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Autores principales:	Aamir Salam Teeli, Kamila Łuczyńska, Effi Haque, Mohmmad Abrar Gayas, Dawid Winiarczyk, Hiroaki Taniguchi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma HNF4α HNF1α inflammation β-catenin EMT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4a03c20a0c544ba5af6e3277f3e3c350
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spelling	oai:doaj.org-article:4a03c20a0c544ba5af6e3277f3e3c3502021-11-11T15:28:57ZDisruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver10.3390/cancers132153572072-6694https://doaj.org/article/4a03c20a0c544ba5af6e3277f3e3c3502021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5357https://doaj.org/toc/2072-6694The hepatocyte nuclear factor-4α (HNF4α) and hepatocyte nuclear factor-1α (HNF1α) are transcription factors that influence the development and maintenance of homeostasis in a variety of tissues, including the liver. As such, disruptions in their transcriptional networks can herald a number of pathologies, such as tumorigenesis. Largely considered tumor suppressants in liver cancer, these transcription factors regulate key events of inflammation, epithelial–mesenchymal transition, metabolic reprogramming, and the differentiation status of the cell. High-throughput analysis of cancer cell genomes has identified a number of hotspot mutations in HNF1α and HNF4α in liver cancer. Such results also showcase HNF1α and HNF4α as important therapeutic targets helping us step into the era of personalized medicine. In this review, we update current findings on the roles of HNF1α and HNF4α in liver cancer development and progression. It covers the molecular mechanisms of HNF1α and HNF4α dysregulation and also highlights the potential of HNF4α as a therapeutic target in liver cancer.Aamir Salam TeeliKamila ŁuczyńskaEffi HaqueMohmmad Abrar GayasDawid WiniarczykHiroaki TaniguchiMDPI AGarticlehepatocellular carcinomaHNF4αHNF1αinflammationβ-cateninEMTNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5357, p 5357 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma HNF4α HNF1α inflammation β-catenin EMT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma HNF4α HNF1α inflammation β-catenin EMT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Aamir Salam Teeli Kamila Łuczyńska Effi Haque Mohmmad Abrar Gayas Dawid Winiarczyk Hiroaki Taniguchi Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
description	The hepatocyte nuclear factor-4α (HNF4α) and hepatocyte nuclear factor-1α (HNF1α) are transcription factors that influence the development and maintenance of homeostasis in a variety of tissues, including the liver. As such, disruptions in their transcriptional networks can herald a number of pathologies, such as tumorigenesis. Largely considered tumor suppressants in liver cancer, these transcription factors regulate key events of inflammation, epithelial–mesenchymal transition, metabolic reprogramming, and the differentiation status of the cell. High-throughput analysis of cancer cell genomes has identified a number of hotspot mutations in HNF1α and HNF4α in liver cancer. Such results also showcase HNF1α and HNF4α as important therapeutic targets helping us step into the era of personalized medicine. In this review, we update current findings on the roles of HNF1α and HNF4α in liver cancer development and progression. It covers the molecular mechanisms of HNF1α and HNF4α dysregulation and also highlights the potential of HNF4α as a therapeutic target in liver cancer.
format	article
author	Aamir Salam Teeli Kamila Łuczyńska Effi Haque Mohmmad Abrar Gayas Dawid Winiarczyk Hiroaki Taniguchi
author_facet	Aamir Salam Teeli Kamila Łuczyńska Effi Haque Mohmmad Abrar Gayas Dawid Winiarczyk Hiroaki Taniguchi
author_sort	Aamir Salam Teeli
title	Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
title_short	Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
title_full	Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
title_fullStr	Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
title_full_unstemmed	Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
title_sort	disruption of tumor suppressors hnf4α/hnf1α causes tumorigenesis in liver
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4a03c20a0c544ba5af6e3277f3e3c350
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Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver

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