Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan
Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find that 5-methoxytryptophan and its regulatory enzyme...
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Nature Portfolio
2019
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oai:doaj.org-article:4a04997a433f49e4a807e4cf744638af2021-12-02T15:35:33ZIdentification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan10.1038/s41467-019-09329-02041-1723https://doaj.org/article/4a04997a433f49e4a807e4cf744638af2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09329-0https://doaj.org/toc/2041-1723Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find that 5-methoxytryptophan and its regulatory enzyme TPH-1 exert anti-fibrotic effects in mouse models of kidney injury.Dan-Qian ChenGang CaoHua ChenChristos P. ArgyopoulosHui YuWei SuLin ChenDavid C. SamuelsShougang ZhuangGeorge P. BaylissShilin ZhaoXiao-Yong YuNosratola D. VaziriMing WangDan LiuJia-Rong MaoShi-Xing MaJin ZhaoYuan ZhangYou-Quan ShangHuining KangFei YeXiao-Hong ChengXiang-Ri LiLi ZhangMei-Xia MengYan GuoYing-Yong ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Dan-Qian Chen Gang Cao Hua Chen Christos P. Argyopoulos Hui Yu Wei Su Lin Chen David C. Samuels Shougang Zhuang George P. Bayliss Shilin Zhao Xiao-Yong Yu Nosratola D. Vaziri Ming Wang Dan Liu Jia-Rong Mao Shi-Xing Ma Jin Zhao Yuan Zhang You-Quan Shang Huining Kang Fei Ye Xiao-Hong Cheng Xiang-Ri Li Li Zhang Mei-Xia Meng Yan Guo Ying-Yong Zhao Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan |
| description |
Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find that 5-methoxytryptophan and its regulatory enzyme TPH-1 exert anti-fibrotic effects in mouse models of kidney injury. |
| format |
article |
| author |
Dan-Qian Chen Gang Cao Hua Chen Christos P. Argyopoulos Hui Yu Wei Su Lin Chen David C. Samuels Shougang Zhuang George P. Bayliss Shilin Zhao Xiao-Yong Yu Nosratola D. Vaziri Ming Wang Dan Liu Jia-Rong Mao Shi-Xing Ma Jin Zhao Yuan Zhang You-Quan Shang Huining Kang Fei Ye Xiao-Hong Cheng Xiang-Ri Li Li Zhang Mei-Xia Meng Yan Guo Ying-Yong Zhao |
| author_facet |
Dan-Qian Chen Gang Cao Hua Chen Christos P. Argyopoulos Hui Yu Wei Su Lin Chen David C. Samuels Shougang Zhuang George P. Bayliss Shilin Zhao Xiao-Yong Yu Nosratola D. Vaziri Ming Wang Dan Liu Jia-Rong Mao Shi-Xing Ma Jin Zhao Yuan Zhang You-Quan Shang Huining Kang Fei Ye Xiao-Hong Cheng Xiang-Ri Li Li Zhang Mei-Xia Meng Yan Guo Ying-Yong Zhao |
| author_sort |
Dan-Qian Chen |
| title |
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan |
| title_short |
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan |
| title_full |
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan |
| title_fullStr |
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan |
| title_full_unstemmed |
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan |
| title_sort |
identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4a04997a433f49e4a807e4cf744638af |
| work_keys_str_mv |
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