Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera

Summary: Highly transmissible SARS-CoV-2 variants identified in India and designated B.1.617, Kappa (B.1.617.1), Delta (B.1.617.2), B.1.618, and B.1.36.29 contain spike mutations L452R, T478K, E484K, E484Q, and N440K located within the spike receptor-binding domain and thus could contribute to incre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takuya Tada, Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Mark J. Mulligan, Nathaniel R. Landau
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences Immune response Virology Science Q
Acceso en línea:	https://doaj.org/article/4a04efff253c4798a3fb65a02845653c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4a04efff253c4798a3fb65a02845653c
record_format	dspace
spelling	oai:doaj.org-article:4a04efff253c4798a3fb65a02845653c2021-11-20T05:10:11ZPartial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera2589-004210.1016/j.isci.2021.103341https://doaj.org/article/4a04efff253c4798a3fb65a02845653c2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013109https://doaj.org/toc/2589-0042Summary: Highly transmissible SARS-CoV-2 variants identified in India and designated B.1.617, Kappa (B.1.617.1), Delta (B.1.617.2), B.1.618, and B.1.36.29 contain spike mutations L452R, T478K, E484K, E484Q, and N440K located within the spike receptor-binding domain and thus could contribute to increased transmissibility and potentially allow re-infection or cause resistance to vaccine-elicited antibody. To address these issues, we used lentiviruses pseudotyped by variant spikes to measure their neutralization by convalescent sera, vaccine-elicited and Regeneron therapeutic antibodies, and ACE2 affinity. Convalescent sera and vaccine-elicited antibodies neutralized viruses with Delta spike with 2- to 5-fold decrease in titer in different donors. Regeneron antibody cocktail neutralized virus with the Delta spike with a 2.6-fold decrease in titer. Neutralization resistance to serum antibodies and monoclonal antibodies was mediated by L452R mutation. These relatively modest decreases in antibody neutralization titer for viruses with variant spike proteins suggest that current vaccines will remain protective against the family of Delta variants.Takuya TadaHao ZhouBelinda M. DcostaMarie I. SamanovicMark J. MulliganNathaniel R. LandauElsevierarticleBiological sciencesImmune responseVirologyScienceQENiScience, Vol 24, Iss 11, Pp 103341- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences Immune response Virology Science Q
spellingShingle	Biological sciences Immune response Virology Science Q Takuya Tada Hao Zhou Belinda M. Dcosta Marie I. Samanovic Mark J. Mulligan Nathaniel R. Landau Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
description	Summary: Highly transmissible SARS-CoV-2 variants identified in India and designated B.1.617, Kappa (B.1.617.1), Delta (B.1.617.2), B.1.618, and B.1.36.29 contain spike mutations L452R, T478K, E484K, E484Q, and N440K located within the spike receptor-binding domain and thus could contribute to increased transmissibility and potentially allow re-infection or cause resistance to vaccine-elicited antibody. To address these issues, we used lentiviruses pseudotyped by variant spikes to measure their neutralization by convalescent sera, vaccine-elicited and Regeneron therapeutic antibodies, and ACE2 affinity. Convalescent sera and vaccine-elicited antibodies neutralized viruses with Delta spike with 2- to 5-fold decrease in titer in different donors. Regeneron antibody cocktail neutralized virus with the Delta spike with a 2.6-fold decrease in titer. Neutralization resistance to serum antibodies and monoclonal antibodies was mediated by L452R mutation. These relatively modest decreases in antibody neutralization titer for viruses with variant spike proteins suggest that current vaccines will remain protective against the family of Delta variants.
format	article
author	Takuya Tada Hao Zhou Belinda M. Dcosta Marie I. Samanovic Mark J. Mulligan Nathaniel R. Landau
author_facet	Takuya Tada Hao Zhou Belinda M. Dcosta Marie I. Samanovic Mark J. Mulligan Nathaniel R. Landau
author_sort	Takuya Tada
title	Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
title_short	Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
title_full	Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
title_fullStr	Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
title_full_unstemmed	Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
title_sort	partial resistance of sars-cov-2 delta variants to vaccine-elicited antibodies and convalescent sera
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4a04efff253c4798a3fb65a02845653c
work_keys_str_mv	AT takuyatada partialresistanceofsarscov2deltavariantstovaccineelicitedantibodiesandconvalescentsera AT haozhou partialresistanceofsarscov2deltavariantstovaccineelicitedantibodiesandconvalescentsera AT belindamdcosta partialresistanceofsarscov2deltavariantstovaccineelicitedantibodiesandconvalescentsera AT marieisamanovic partialresistanceofsarscov2deltavariantstovaccineelicitedantibodiesandconvalescentsera AT markjmulligan partialresistanceofsarscov2deltavariantstovaccineelicitedantibodiesandconvalescentsera AT nathanielrlandau partialresistanceofsarscov2deltavariantstovaccineelicitedantibodiesandconvalescentsera
_version_	1718419538708529152

Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera

Ejemplares similares