Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile

We analyzed the neurological manifestations in Mexican patients hospitalized with pneumonia due to COVID-19 and investigated the association between demographic, clinical, and biochemical variables and outcomes, including death. A retrospective, analytical study was conducted using the electronic re...

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Autores principales:	Silvia García, Francisco Manuel Cuatepotzo-Burgos, Christian Gabriel Toledo-Lozano, Adriana Balderrama-Soto, Sofía Lizeth Alcaraz-Estrada, Luis Montiel-López, Alberto Hilarión De la Vega-Bravo, Paul Mondragón-Terán, Maribel Santosbeña-Lagunes, Maricela Escarela-Serrano, Celia Mireya Rodríguez-Martínez, María del Carmen Méndez-Vidrio, Sandra Muñoz-López, José Alfredo Merino-Rajme, Rodrigo Alberto Rodríguez-Briseño, Fidel Cerda-Téllez, Ramón Mauricio Coral-Vázquez, Sergio Sauri-Suárez, Sandra Quiñonez-Aguilar, Juan Antonio Pineda-Juárez, Juan Antonio Suárez-Cuenca
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	case fatality ratio COVID-19 neurological symptoms respiratory infection risk profile Medicine R
Acceso en línea:	https://doaj.org/article/4a05e40400f44e5fb838a2ab54c785a2
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spelling	oai:doaj.org-article:4a05e40400f44e5fb838a2ab54c785a22021-11-25T17:45:06ZNeurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile10.3390/healthcare91115012227-9032https://doaj.org/article/4a05e40400f44e5fb838a2ab54c785a22021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1501https://doaj.org/toc/2227-9032We analyzed the neurological manifestations in Mexican patients hospitalized with pneumonia due to COVID-19 and investigated the association between demographic, clinical, and biochemical variables and outcomes, including death. A retrospective, analytical study was conducted using the electronic records of patients hospitalized between 1 April 2020 and 30 September 2020. Records of 1040 patients were analyzed: 31.25% died and 79.42% had neurological symptoms, including headache (80.62%), anosmia (32.20%), ageusia (31.96%), myopathy (28.08%), disorientation (14.89%), encephalopathy (12.22%), neuropathy (5.4%), stroke (1.3%), seizures (1.3%), cerebral hemorrhage (1.08%), encephalitis (0.84%), central venous thrombosis (0.36%), and subarachnoid hemorrhage (0.24%). Patients also had comorbidities, such as hypertension (42.30%), diabetes mellitus (38.74%), obesity (61.34%), chronic obstructive pulmonary disease (3.17%), and asthma (2.01%). Factors associated with neurological symptoms were dyspnea, chronic obstructive pulmonary disease, advanced respiratory support, prolonged hospitalization, and worsening fibrinogen levels. Factors associated with death were older age, advanced respiratory support, amine management, chronic obstructive pulmonary disease, intensive care unit management, dyspnea, disorientation, encephalopathy, hypertension, neuropathy, diabetes, male sex, three or more neurological symptoms, and obesity grade 3. In this study we designed a profile to help predict patients at higher risk of developing neurological complications and death following COVID-19 infection.Silvia GarcíaFrancisco Manuel Cuatepotzo-BurgosChristian Gabriel Toledo-LozanoAdriana Balderrama-SotoSofía Lizeth Alcaraz-EstradaLuis Montiel-LópezAlberto Hilarión De la Vega-BravoPaul Mondragón-TeránMaribel Santosbeña-LagunesMaricela Escarela-SerranoCelia Mireya Rodríguez-MartínezMaría del Carmen Méndez-VidrioSandra Muñoz-LópezJosé Alfredo Merino-RajmeRodrigo Alberto Rodríguez-BriseñoFidel Cerda-TéllezRamón Mauricio Coral-VázquezSergio Sauri-SuárezSandra Quiñonez-AguilarJuan Antonio Pineda-JuárezJuan Antonio Suárez-CuencaMDPI AGarticlecase fatality ratioCOVID-19neurological symptomsrespiratory infectionrisk profileMedicineRENHealthcare, Vol 9, Iss 1501, p 1501 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case fatality ratio COVID-19 neurological symptoms respiratory infection risk profile Medicine R
spellingShingle	case fatality ratio COVID-19 neurological symptoms respiratory infection risk profile Medicine R Silvia García Francisco Manuel Cuatepotzo-Burgos Christian Gabriel Toledo-Lozano Adriana Balderrama-Soto Sofía Lizeth Alcaraz-Estrada Luis Montiel-López Alberto Hilarión De la Vega-Bravo Paul Mondragón-Terán Maribel Santosbeña-Lagunes Maricela Escarela-Serrano Celia Mireya Rodríguez-Martínez María del Carmen Méndez-Vidrio Sandra Muñoz-López José Alfredo Merino-Rajme Rodrigo Alberto Rodríguez-Briseño Fidel Cerda-Téllez Ramón Mauricio Coral-Vázquez Sergio Sauri-Suárez Sandra Quiñonez-Aguilar Juan Antonio Pineda-Juárez Juan Antonio Suárez-Cuenca Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile
description	We analyzed the neurological manifestations in Mexican patients hospitalized with pneumonia due to COVID-19 and investigated the association between demographic, clinical, and biochemical variables and outcomes, including death. A retrospective, analytical study was conducted using the electronic records of patients hospitalized between 1 April 2020 and 30 September 2020. Records of 1040 patients were analyzed: 31.25% died and 79.42% had neurological symptoms, including headache (80.62%), anosmia (32.20%), ageusia (31.96%), myopathy (28.08%), disorientation (14.89%), encephalopathy (12.22%), neuropathy (5.4%), stroke (1.3%), seizures (1.3%), cerebral hemorrhage (1.08%), encephalitis (0.84%), central venous thrombosis (0.36%), and subarachnoid hemorrhage (0.24%). Patients also had comorbidities, such as hypertension (42.30%), diabetes mellitus (38.74%), obesity (61.34%), chronic obstructive pulmonary disease (3.17%), and asthma (2.01%). Factors associated with neurological symptoms were dyspnea, chronic obstructive pulmonary disease, advanced respiratory support, prolonged hospitalization, and worsening fibrinogen levels. Factors associated with death were older age, advanced respiratory support, amine management, chronic obstructive pulmonary disease, intensive care unit management, dyspnea, disorientation, encephalopathy, hypertension, neuropathy, diabetes, male sex, three or more neurological symptoms, and obesity grade 3. In this study we designed a profile to help predict patients at higher risk of developing neurological complications and death following COVID-19 infection.
format	article
author	Silvia García Francisco Manuel Cuatepotzo-Burgos Christian Gabriel Toledo-Lozano Adriana Balderrama-Soto Sofía Lizeth Alcaraz-Estrada Luis Montiel-López Alberto Hilarión De la Vega-Bravo Paul Mondragón-Terán Maribel Santosbeña-Lagunes Maricela Escarela-Serrano Celia Mireya Rodríguez-Martínez María del Carmen Méndez-Vidrio Sandra Muñoz-López José Alfredo Merino-Rajme Rodrigo Alberto Rodríguez-Briseño Fidel Cerda-Téllez Ramón Mauricio Coral-Vázquez Sergio Sauri-Suárez Sandra Quiñonez-Aguilar Juan Antonio Pineda-Juárez Juan Antonio Suárez-Cuenca
author_facet	Silvia García Francisco Manuel Cuatepotzo-Burgos Christian Gabriel Toledo-Lozano Adriana Balderrama-Soto Sofía Lizeth Alcaraz-Estrada Luis Montiel-López Alberto Hilarión De la Vega-Bravo Paul Mondragón-Terán Maribel Santosbeña-Lagunes Maricela Escarela-Serrano Celia Mireya Rodríguez-Martínez María del Carmen Méndez-Vidrio Sandra Muñoz-López José Alfredo Merino-Rajme Rodrigo Alberto Rodríguez-Briseño Fidel Cerda-Téllez Ramón Mauricio Coral-Vázquez Sergio Sauri-Suárez Sandra Quiñonez-Aguilar Juan Antonio Pineda-Juárez Juan Antonio Suárez-Cuenca
author_sort	Silvia García
title	Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile
title_short	Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile
title_full	Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile
title_fullStr	Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile
title_full_unstemmed	Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile
title_sort	neurological manifestations and outcomes in a retrospective cohort of mexican inpatients with sars-cov-2 pneumonia: design of a risk profile
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4a05e40400f44e5fb838a2ab54c785a2
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Neurological Manifestations and Outcomes in a Retrospective Cohort of Mexican Inpatients with SARS-CoV-2 Pneumonia: Design of a Risk Profile

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