SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

Why children are generally less susceptible than adults to COVID-19 is unclear and has not extensively been examined longitudinally. Here the authors compare antibodies, cytokines and immune cell responses in adults and children over 6 months post-infection showing, among other things, a reduced CD4...

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Autores principales:	Carolyn A. Cohen, Athena P. Y. Li, Asmaa Hachim, David S. C. Hui, Mike Y. W. Kwan, Owen T. Y. Tsang, Susan S. Chiu, Wai Hung Chan, Yat Sun Yau, Niloufar Kavian, Fionn N. L. Ma, Eric H. Y. Lau, Samuel M. S. Cheng, Leo L. M. Poon, Malik Peiris, Sophie A. Valkenburg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a06b354eca4474d953f5855491515f4
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spelling	oai:doaj.org-article:4a06b354eca4474d953f5855491515f42021-12-02T16:24:23ZSARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection10.1038/s41467-021-24938-42041-1723https://doaj.org/article/4a06b354eca4474d953f5855491515f42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24938-4https://doaj.org/toc/2041-1723Why children are generally less susceptible than adults to COVID-19 is unclear and has not extensively been examined longitudinally. Here the authors compare antibodies, cytokines and immune cell responses in adults and children over 6 months post-infection showing, among other things, a reduced CD4+ and CD8+ T cell response in children.Carolyn A. CohenAthena P. Y. LiAsmaa HachimDavid S. C. HuiMike Y. W. KwanOwen T. Y. TsangSusan S. ChiuWai Hung ChanYat Sun YauNiloufar KavianFionn N. L. MaEric H. Y. LauSamuel M. S. ChengLeo L. M. PoonMalik PeirisSophie A. ValkenburgNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carolyn A. Cohen Athena P. Y. Li Asmaa Hachim David S. C. Hui Mike Y. W. Kwan Owen T. Y. Tsang Susan S. Chiu Wai Hung Chan Yat Sun Yau Niloufar Kavian Fionn N. L. Ma Eric H. Y. Lau Samuel M. S. Cheng Leo L. M. Poon Malik Peiris Sophie A. Valkenburg SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
description	Why children are generally less susceptible than adults to COVID-19 is unclear and has not extensively been examined longitudinally. Here the authors compare antibodies, cytokines and immune cell responses in adults and children over 6 months post-infection showing, among other things, a reduced CD4+ and CD8+ T cell response in children.
format	article
author	Carolyn A. Cohen Athena P. Y. Li Asmaa Hachim David S. C. Hui Mike Y. W. Kwan Owen T. Y. Tsang Susan S. Chiu Wai Hung Chan Yat Sun Yau Niloufar Kavian Fionn N. L. Ma Eric H. Y. Lau Samuel M. S. Cheng Leo L. M. Poon Malik Peiris Sophie A. Valkenburg
author_facet	Carolyn A. Cohen Athena P. Y. Li Asmaa Hachim David S. C. Hui Mike Y. W. Kwan Owen T. Y. Tsang Susan S. Chiu Wai Hung Chan Yat Sun Yau Niloufar Kavian Fionn N. L. Ma Eric H. Y. Lau Samuel M. S. Cheng Leo L. M. Poon Malik Peiris Sophie A. Valkenburg
author_sort	Carolyn A. Cohen
title	SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
title_short	SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
title_full	SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
title_fullStr	SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
title_full_unstemmed	SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection
title_sort	sars-cov-2 specific t cell responses are lower in children and increase with age and time after infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4a06b354eca4474d953f5855491515f4
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SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

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