The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model

BACKGROUND AND OBJECTIVE: Tanacetum parthenium has been introduced as an analgesic agent in traditional medicine and it is widely used to relieve neuropathic pain and headache. The present study was conducted to investigate the analgesic effect of Tanacetum parthenium extract using formalin test. ME...

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Autores principales:	N Parvin, A Asgari
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	acute pain chronic pain formalin test Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4a07113c00fb43bfa1a8fc4a6404ee77
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spelling	oai:doaj.org-article:4a07113c00fb43bfa1a8fc4a6404ee772021-11-10T08:52:02ZThe Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model1561-41072251-7170https://doaj.org/article/4a07113c00fb43bfa1a8fc4a6404ee772012-01-01T00:00:00Zhttp://jbums.org/article-1-3984-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Tanacetum parthenium has been introduced as an analgesic agent in traditional medicine and it is widely used to relieve neuropathic pain and headache. The present study was conducted to investigate the analgesic effect of Tanacetum parthenium extract using formalin test. METHODS: In an experimental study the analgesic effect of Tanacetum parthenium was evaluated by formalin test in 10 groups of 100 adult meal mice, as follows: group distilled water, groups received 10, 20, 30, 40 and 80mg/kg of alcoholic extract, respectively, group received 100 mg/kg ibuprofen, group received 0.5 mg/kg morphine, respectively, group received 0.5 mg/kg naloxon and group received naloxon and extract. Fifteen minutes before formalin injection in foot floor of mice, different doses of extract, ibuprofen, morphine and naloxone injected intraperitoneally in mice. The analgesic effects with observed animal movements and compared in different groups in 30-minute intervals and recorded in two acute and chronic phases.FINDINGS: Among the different doses of extract, 10mg/kg has more analgesic effect in both acute and chronic phases (110.7±19.58), (61±1.15) and showed significant difference with groups ibuprofen and distilled water (p<0.05). The results indicate that the analgesic effect of Tanacetum parthenium is dose dependent and analgesic effect of the extract was inhibited by naloxon (193.6±17.35), (111.5±6.43).CONCLUSION: Results in this study showed a dose-dependent analgesic effect of Tanacetum parthenium in both acute and chronic phases and the decrease in the analgesic effect of naloxone group is probably caused by activation of opioid system.N ParvinA AsgariBabol University of Medical Sciencesarticleacute painchronic painformalin testMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 1, Pp 63-69 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	acute pain chronic pain formalin test Medicine R Medicine (General) R5-920
spellingShingle	acute pain chronic pain formalin test Medicine R Medicine (General) R5-920 N Parvin A Asgari The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model
description	BACKGROUND AND OBJECTIVE: Tanacetum parthenium has been introduced as an analgesic agent in traditional medicine and it is widely used to relieve neuropathic pain and headache. The present study was conducted to investigate the analgesic effect of Tanacetum parthenium extract using formalin test. METHODS: In an experimental study the analgesic effect of Tanacetum parthenium was evaluated by formalin test in 10 groups of 100 adult meal mice, as follows: group distilled water, groups received 10, 20, 30, 40 and 80mg/kg of alcoholic extract, respectively, group received 100 mg/kg ibuprofen, group received 0.5 mg/kg morphine, respectively, group received 0.5 mg/kg naloxon and group received naloxon and extract. Fifteen minutes before formalin injection in foot floor of mice, different doses of extract, ibuprofen, morphine and naloxone injected intraperitoneally in mice. The analgesic effects with observed animal movements and compared in different groups in 30-minute intervals and recorded in two acute and chronic phases.FINDINGS: Among the different doses of extract, 10mg/kg has more analgesic effect in both acute and chronic phases (110.7±19.58), (61±1.15) and showed significant difference with groups ibuprofen and distilled water (p<0.05). The results indicate that the analgesic effect of Tanacetum parthenium is dose dependent and analgesic effect of the extract was inhibited by naloxon (193.6±17.35), (111.5±6.43).CONCLUSION: Results in this study showed a dose-dependent analgesic effect of Tanacetum parthenium in both acute and chronic phases and the decrease in the analgesic effect of naloxone group is probably caused by activation of opioid system.
format	article
author	N Parvin A Asgari
author_facet	N Parvin A Asgari
author_sort	N Parvin
title	The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model
title_short	The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model
title_full	The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model
title_fullStr	The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model
title_full_unstemmed	The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model
title_sort	analgesic effect of alcoholic extract of tanacetum parthenium on pain in mice in formalin model
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/4a07113c00fb43bfa1a8fc4a6404ee77
work_keys_str_mv	AT nparvin theanalgesiceffectofalcoholicextractoftanacetumpartheniumonpaininmiceinformalinmodel AT aasgari theanalgesiceffectofalcoholicextractoftanacetumpartheniumonpaininmiceinformalinmodel AT nparvin analgesiceffectofalcoholicextractoftanacetumpartheniumonpaininmiceinformalinmodel AT aasgari analgesiceffectofalcoholicextractoftanacetumpartheniumonpaininmiceinformalinmodel
_version_	1718440369415258112

The Analgesic Effect of Alcoholic Extract of Tanacetum Parthenium on Pain in Mice in Formalin Model

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