Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy

Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy

Wei Chen,1 Fan-Gang Meng2,3 1Department of Neurology, Liaocheng People’s Hospital, Liaocheng, 2Beijing Neurosurgical Institute, Capital Medical University, 3Beijing Key Laboratory of Neuromodulation, Beijing Municipal Science and Technology Commission, Beijing, People’s Republic...

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Autores principales: Chen W, Meng FG
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Heart rate changes
VNS efficacy
Refractory epilepsy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/4a090dca9b5a45e981064f5108e63f1f
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spelling oai:doaj.org-article:4a090dca9b5a45e981064f5108e63f1f2021-12-02T05:03:57ZIctal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy1178-2021https://doaj.org/article/4a090dca9b5a45e981064f5108e63f1f2017-09-01T00:00:00Zhttps://www.dovepress.com/ictal-heart-rate-changes-and-the-effects-of-vagus-nerve-stimulation-fo-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wei Chen,1 Fan-Gang Meng2,3 1Department of Neurology, Liaocheng People’s Hospital, Liaocheng, 2Beijing Neurosurgical Institute, Capital Medical University, 3Beijing Key Laboratory of Neuromodulation, Beijing Municipal Science and Technology Commission, Beijing, People’s Republic of China Abstract: Vagus nerve stimulation (VNS) shows long-term efficiency worldwide in most pharmacoresistant patients with epilepsy; however, there are still a small number of patients who are non-responders to VNS therapy. It has been shown that VNS treatment outcomes for drug-resistant epilepsy may be predicted by preoperative heart-rate variability measurements and that patients with epilepsy with ictal tachycardia (IT) during seizures have good responses to VNS. However, few studies have reported the efficacy of VNS in patients with epilepsy with ictal bradycardia (IB) or normal heart rate (HR), and none have explored the possible mechanisms of VNS efficacy based on different HR types. HR during seizures varies, and we presume that different HRs during seizures may impact the effects of VNS. It has been shown that blood pressure in the human body needs to be maintained through the arterial baroreflex (ABR). VNS efficacy in patients with epilepsy with IT, IB, and normal HR during seizures may be related to ABR. Mechanical signals generated by VNS are similar to the autonomic nerve pathways and, thus, we propose the hypothesis that different HRs during seizures can predict VNS efficacy in patients. If VNS is highly efficient in patients with IT during seizures, VNS in patients with a normal HR during seizures may be less efficient, and may even be inefficient in patients with IB during seizures. Keywords: heart rate changes, VNS efficacy, refractory epilepsy Chen WMeng FGDove Medical PressarticleHeart rate changesVNS efficacyRefractory epilepsyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2351-2356 (2017)
institution DOAJ
collection DOAJ
language EN
topic Heart rate changes
VNS efficacy
Refractory epilepsy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Heart rate changes
VNS efficacy
Refractory epilepsy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Chen W
Meng FG
Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy
description Wei Chen,1 Fan-Gang Meng2,3 1Department of Neurology, Liaocheng People’s Hospital, Liaocheng, 2Beijing Neurosurgical Institute, Capital Medical University, 3Beijing Key Laboratory of Neuromodulation, Beijing Municipal Science and Technology Commission, Beijing, People’s Republic of China Abstract: Vagus nerve stimulation (VNS) shows long-term efficiency worldwide in most pharmacoresistant patients with epilepsy; however, there are still a small number of patients who are non-responders to VNS therapy. It has been shown that VNS treatment outcomes for drug-resistant epilepsy may be predicted by preoperative heart-rate variability measurements and that patients with epilepsy with ictal tachycardia (IT) during seizures have good responses to VNS. However, few studies have reported the efficacy of VNS in patients with epilepsy with ictal bradycardia (IB) or normal heart rate (HR), and none have explored the possible mechanisms of VNS efficacy based on different HR types. HR during seizures varies, and we presume that different HRs during seizures may impact the effects of VNS. It has been shown that blood pressure in the human body needs to be maintained through the arterial baroreflex (ABR). VNS efficacy in patients with epilepsy with IT, IB, and normal HR during seizures may be related to ABR. Mechanical signals generated by VNS are similar to the autonomic nerve pathways and, thus, we propose the hypothesis that different HRs during seizures can predict VNS efficacy in patients. If VNS is highly efficient in patients with IT during seizures, VNS in patients with a normal HR during seizures may be less efficient, and may even be inefficient in patients with IB during seizures. Keywords: heart rate changes, VNS efficacy, refractory epilepsy 
format article
author Chen W
Meng FG
author_facet Chen W
Meng FG
author_sort Chen W
title Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy
title_short Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy
title_full Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy
title_fullStr Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy
title_full_unstemmed Ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy
title_sort ictal heart rate changes and the effects of vagus nerve stimulation for patients with refractory epilepsy
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/4a090dca9b5a45e981064f5108e63f1f
work_keys_str_mv AT chenw ictalheartratechangesandtheeffectsofvagusnervestimulationforpatientswithrefractoryepilepsy
AT mengfg ictalheartratechangesandtheeffectsofvagusnervestimulationforpatientswithrefractoryepilepsy
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