Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy

The vibrational signature in the far-infrared region of two different phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), was investigated as a function of relative humidity from 0 to 75% in order to evaluate the effect of headgroup composition on the formation of intermolecul...

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Autores principales:	Valeria Conti Nibali, Caterina Branca, Ulderico Wanderlingh, Giovanna D’Angelo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	far-IR spectroscopy terahertz gap phospholipid membranes phosphatidylcholine phosphatidylethanolamine hydrogen-bonding continuum Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4a0c249faed34443b5069db99b04c4ae
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spelling	oai:doaj.org-article:4a0c249faed34443b5069db99b04c4ae2021-11-11T15:07:09ZIntermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy10.3390/app1121100382076-3417https://doaj.org/article/4a0c249faed34443b5069db99b04c4ae2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10038https://doaj.org/toc/2076-3417The vibrational signature in the far-infrared region of two different phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), was investigated as a function of relative humidity from 0 to 75% in order to evaluate the effect of headgroup composition on the formation of intermolecular interactions. The substructures of the frequency region between 50 and 300 cm<sup>−1</sup> were identified, and changes in the frequency and intensity of the related vibrations with hydration were analyzed. Interestingly, in PE, two additional vibrational bands with respect to PC were found at 162 and 236 cm<sup>−1</sup> and assigned to intermolecular hydrogen bonds between the hydrogen-bond-donating groups, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mrow><mo>-</mo><mi>NH</mi></mrow></mrow><mn>3</mn><mo>+</mo></msubsup></mrow></semantics></math></inline-formula>, and hydrogen-bond-accepting groups, —P—O− and —COO, of adjacent molecules. The presence of these interactions also affected the penetration of water, severely reducing the hydration capability of PE lipids.Valeria Conti NibaliCaterina BrancaUlderico WanderlinghGiovanna D’AngeloMDPI AGarticlefar-IR spectroscopyterahertz gapphospholipid membranesphosphatidylcholinephosphatidylethanolaminehydrogen-bonding continuumTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10038, p 10038 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	far-IR spectroscopy terahertz gap phospholipid membranes phosphatidylcholine phosphatidylethanolamine hydrogen-bonding continuum Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	far-IR spectroscopy terahertz gap phospholipid membranes phosphatidylcholine phosphatidylethanolamine hydrogen-bonding continuum Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Valeria Conti Nibali Caterina Branca Ulderico Wanderlingh Giovanna D’Angelo Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy
description	The vibrational signature in the far-infrared region of two different phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), was investigated as a function of relative humidity from 0 to 75% in order to evaluate the effect of headgroup composition on the formation of intermolecular interactions. The substructures of the frequency region between 50 and 300 cm<sup>−1</sup> were identified, and changes in the frequency and intensity of the related vibrations with hydration were analyzed. Interestingly, in PE, two additional vibrational bands with respect to PC were found at 162 and 236 cm<sup>−1</sup> and assigned to intermolecular hydrogen bonds between the hydrogen-bond-donating groups, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mrow><mo>-</mo><mi>NH</mi></mrow></mrow><mn>3</mn><mo>+</mo></msubsup></mrow></semantics></math></inline-formula>, and hydrogen-bond-accepting groups, —P—O− and —COO, of adjacent molecules. The presence of these interactions also affected the penetration of water, severely reducing the hydration capability of PE lipids.
format	article
author	Valeria Conti Nibali Caterina Branca Ulderico Wanderlingh Giovanna D’Angelo
author_facet	Valeria Conti Nibali Caterina Branca Ulderico Wanderlingh Giovanna D’Angelo
author_sort	Valeria Conti Nibali
title	Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy
title_short	Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy
title_full	Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy
title_fullStr	Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy
title_full_unstemmed	Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy
title_sort	intermolecular hydrogen-bond interactions in dppe and dmpc phospholipid membranes revealed by far-infrared spectroscopy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4a0c249faed34443b5069db99b04c4ae
work_keys_str_mv	AT valeriacontinibali intermolecularhydrogenbondinteractionsindppeanddmpcphospholipidmembranesrevealedbyfarinfraredspectroscopy AT caterinabranca intermolecularhydrogenbondinteractionsindppeanddmpcphospholipidmembranesrevealedbyfarinfraredspectroscopy AT uldericowanderlingh intermolecularhydrogenbondinteractionsindppeanddmpcphospholipidmembranesrevealedbyfarinfraredspectroscopy AT giovannadangelo intermolecularhydrogenbondinteractionsindppeanddmpcphospholipidmembranesrevealedbyfarinfraredspectroscopy
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Intermolecular Hydrogen-Bond Interactions in DPPE and DMPC Phospholipid Membranes Revealed by Far-Infrared Spectroscopy

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