Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model

Pei-pei Zheng,1,2 Li-na Zhang,1 Jie Zhang,1 Xin-miao Chang,1 Shan Ding,1 Fei Xiao,3 Li-xin Guo1 1Department of Endocrinology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, People’s Republic of China;...

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Autores principales:	Zheng PP, Zhang LN, Zhang J, Chang XM, Ding S, Xiao F, Guo LX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	night work sleep deprivation sleep supplement sleep debt body weight glucose metabolism insulitis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/4a0c807fab604a4684968d92a51e7665
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spelling	oai:doaj.org-article:4a0c807fab604a4684968d92a51e76652021-12-02T12:57:03ZEvaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model1179-1608https://doaj.org/article/4a0c807fab604a4684968d92a51e76652020-11-01T00:00:00Zhttps://www.dovepress.com/evaluating-the-effects-of-different-sleep-supplement-modes-in-attenuat-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Pei-pei Zheng,1,2 Li-na Zhang,1 Jie Zhang,1 Xin-miao Chang,1 Shan Ding,1 Fei Xiao,3 Li-xin Guo1 1Department of Endocrinology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, People’s Republic of China; 2Peking University Fifth School of Clinical Medicine, Beijing 100730, People’s Republic of China; 3The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Bejing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing, 100730, People’s Republic of ChinaCorrespondence: Li-xin GuoDepartment of Endocrinology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, NO. 1 DaHua Road, Dong Dan, Beijing 100730, People’s Republic of ChinaTel/Fax +86-10-65282171Email lixinguo_med@163.comPurpose: To study the effects of chronic-simulated night shift work using the rat model and examines if a particular sleep supplement mode could be better in alleviating the effects.Methods: The male Wistar rats were randomly divided into the control (CTL: 8 rats) and night shift work (NW: 24 rats) groups of rats. Based on the sleep supplement strategy, the NW group was further segregated into three subgroups (8 rats each); late sleep supplement group (LSS), early sleep supplement group (ESS), and intermittent sleep supplement group (ISS). Sleep deprivation was achieved using the standard small-platform-over water method. Parameters such as animal body weight and food intake were measured daily. The intraperitoneal glucose tolerance test, fasting plasma insulin concentration, insulin resistance index and insulin sensitivity were measured twice, in the 4th and 8th weeks of the study. Plasma corticosterone concentration and pathological changes in islets (insulitis) were measured at the end of the 8th week.Results: In NW group, night work resulted in a gain of body weight and albeit lower than that of the CTL group. NW rats also had higher food intake, showed impaired glucose metabolism and higher plasma corticosterone concentration. The sleep supplement experiments suggested that compared to the other modes, intermittent sleep supplement had significantly low changes in the body weight, glucose metabolism and the islet cells.Conclusion: Similar to previous studies, we also found that night shift work adversely impacts the body weight and glucose metabolism in rats. However, upon evaluating different sleep supplement strategies, we found the intermittent sleep supplement strategy to be most effective.Keywords: night work, sleep deprivation, sleep supplement, sleep debt, body weight, glucose metabolism, insulitisZheng PPZhang LNZhang JChang XMDing SXiao FGuo LXDove Medical Pressarticlenight worksleep deprivationsleep supplementsleep debtbody weightglucose metabolisminsulitisPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 1053-1065 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	night work sleep deprivation sleep supplement sleep debt body weight glucose metabolism insulitis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	night work sleep deprivation sleep supplement sleep debt body weight glucose metabolism insulitis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Zheng PP Zhang LN Zhang J Chang XM Ding S Xiao F Guo LX Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model
description	Pei-pei Zheng,1,2 Li-na Zhang,1 Jie Zhang,1 Xin-miao Chang,1 Shan Ding,1 Fei Xiao,3 Li-xin Guo1 1Department of Endocrinology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, People’s Republic of China; 2Peking University Fifth School of Clinical Medicine, Beijing 100730, People’s Republic of China; 3The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Bejing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing, 100730, People’s Republic of ChinaCorrespondence: Li-xin GuoDepartment of Endocrinology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, NO. 1 DaHua Road, Dong Dan, Beijing 100730, People’s Republic of ChinaTel/Fax +86-10-65282171Email lixinguo_med@163.comPurpose: To study the effects of chronic-simulated night shift work using the rat model and examines if a particular sleep supplement mode could be better in alleviating the effects.Methods: The male Wistar rats were randomly divided into the control (CTL: 8 rats) and night shift work (NW: 24 rats) groups of rats. Based on the sleep supplement strategy, the NW group was further segregated into three subgroups (8 rats each); late sleep supplement group (LSS), early sleep supplement group (ESS), and intermittent sleep supplement group (ISS). Sleep deprivation was achieved using the standard small-platform-over water method. Parameters such as animal body weight and food intake were measured daily. The intraperitoneal glucose tolerance test, fasting plasma insulin concentration, insulin resistance index and insulin sensitivity were measured twice, in the 4th and 8th weeks of the study. Plasma corticosterone concentration and pathological changes in islets (insulitis) were measured at the end of the 8th week.Results: In NW group, night work resulted in a gain of body weight and albeit lower than that of the CTL group. NW rats also had higher food intake, showed impaired glucose metabolism and higher plasma corticosterone concentration. The sleep supplement experiments suggested that compared to the other modes, intermittent sleep supplement had significantly low changes in the body weight, glucose metabolism and the islet cells.Conclusion: Similar to previous studies, we also found that night shift work adversely impacts the body weight and glucose metabolism in rats. However, upon evaluating different sleep supplement strategies, we found the intermittent sleep supplement strategy to be most effective.Keywords: night work, sleep deprivation, sleep supplement, sleep debt, body weight, glucose metabolism, insulitis
format	article
author	Zheng PP Zhang LN Zhang J Chang XM Ding S Xiao F Guo LX
author_facet	Zheng PP Zhang LN Zhang J Chang XM Ding S Xiao F Guo LX
author_sort	Zheng PP
title	Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model
title_short	Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model
title_full	Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model
title_fullStr	Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model
title_full_unstemmed	Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model
title_sort	evaluating the effects of different sleep supplement modes in attenuating metabolic consequences of night shift work using rat model
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/4a0c807fab604a4684968d92a51e7665
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Evaluating the Effects of Different Sleep Supplement Modes in Attenuating Metabolic Consequences of Night Shift Work Using Rat Model

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