OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis

Marta Para-Prieto,1,2 Raul Martin,1,3,4 Sara Crespo,2 Laura Mena-Garcia,1 Andres Valisena,2 Lisandro Cordero,1 Gloria Gonzalez Fernandez,2 Juan F Arenillas,5 Nieves Tellez,5 Jose Carlos Pastor1,2 1Universidad de Valladolid, Instituto Universitario de Oftalmobiología Aplicada (IOBA Eye Ins...

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Autores principales:	Para-Prieto M, Martin R, Crespo S, Mena-Garcia L, Valisena A, Cordero L, Gonzalez Fernandez G, Arenillas JF, Tellez N, Pastor JC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	spectral- domain optical coherence tomography multiple sclerosis retinal nerve fibre layer foveal thickness variability Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4a0e56c51ffe4e95b2ce163c33ec0b6b
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spelling	oai:doaj.org-article:4a0e56c51ffe4e95b2ce163c33ec0b6b2021-12-02T16:50:24ZOCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis1177-5483https://doaj.org/article/4a0e56c51ffe4e95b2ce163c33ec0b6b2021-05-01T00:00:00Zhttps://www.dovepress.com/oct-variability-prevents-their-use-as-robust-biomarkers-in-multiple-sc-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Marta Para-Prieto,1,2 Raul Martin,1,3,4 Sara Crespo,2 Laura Mena-Garcia,1 Andres Valisena,2 Lisandro Cordero,1 Gloria Gonzalez Fernandez,2 Juan F Arenillas,5 Nieves Tellez,5 Jose Carlos Pastor1,2 1Universidad de Valladolid, Instituto Universitario de Oftalmobiología Aplicada (IOBA Eye Institute), Valladolid, 47011, Spain; 2Hospital Clínico Universitario, Department of Ophthalmology, Valladolid, 47005, Spain; 3Universidad de Valladolid, Departamento de Física Teórica, Atómica y Óptica, Valladolid, 47011, Spain; 4Plymouth University, Faculty of Health and Human Sciences, Plymouth, UK; 5Hospital Clínico Universitario, Department of Neurology, Valladolid, 47005, SpainCorrespondence: Raul MartinIOBA Eye Institute, University of Valladolid, Paseo de Belen, 17, Valladolid, 47011, SpainTel +34 983 184 848Fax +34 983 184 762Email raul@ioba.med.uva.esObjective: To evaluate the agreement between the peripapillary retinal nerve fiber layer (pRNFL) and foveal thickness (FT) measurements among three different spectral domain-optical coherence tomography (SD-OCT) instruments in a sample of multiple sclerosis (MS) patients and a healthy age-matched control group.Methods: An observational cross-sectional study with three groups: healthy subjects and MS patients w/w a previous clinical diagnosis of optic neuritis (ON) was conducted. The pRNFL and FT were measured using three different SD-OCT instruments (OCT PRIMUS 200 and OCT CIRRUS 500 SD-OCT [Carl Zeiss Meditec] and OCT 3D 2000 [Topcon]).Results: Twenty eyes from 10 healthy subjects matched in age with MS patients without a previous history of eye disease and 62 MS eyes from 31 MS patients (29 eyes without history of ON and 33 eyes with history of ON) were enrolled. Healthy subjects and MS patients without ON did not show differences between the pRNFL and FT thickness (P> 0.99) with any of the instruments. However, MS eyes with a previous episode of ON showed thinner pRNFL and FT (P< 0.01). PRIMUS and CIRRUS OCT showed better agreement of the pRNLF and FT in both healthy and MS eyes. However, 3D OCT showed less agreement in the pRNFL measurement with CIRRUS in both healthy and MS eyes.Interpretation: Although OCT is a valuable technology to improve MS patient assessment, differences between devices must be taken into account. It is necessary to create an international group that standardizes the measurement conditions and above all that provides reference bases for normal subjects.Keywords: spectral-domain optical coherence tomography; SD-OCT, multiple sclerosis; MS, retinal nerve fiber layer; RNFL, foveal thickness; FT, variabilityPara-Prieto MMartin RCrespo SMena-Garcia LValisena ACordero LGonzalez Fernandez GArenillas JFTellez NPastor JCDove Medical Pressarticlespectral- domain optical coherence tomographymultiple sclerosisretinal nerve fibre layerfoveal thicknessvariabilityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2025-2036 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spectral- domain optical coherence tomography multiple sclerosis retinal nerve fibre layer foveal thickness variability Ophthalmology RE1-994
spellingShingle	spectral- domain optical coherence tomography multiple sclerosis retinal nerve fibre layer foveal thickness variability Ophthalmology RE1-994 Para-Prieto M Martin R Crespo S Mena-Garcia L Valisena A Cordero L Gonzalez Fernandez G Arenillas JF Tellez N Pastor JC OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis
description	Marta Para-Prieto,1,2 Raul Martin,1,3,4 Sara Crespo,2 Laura Mena-Garcia,1 Andres Valisena,2 Lisandro Cordero,1 Gloria Gonzalez Fernandez,2 Juan F Arenillas,5 Nieves Tellez,5 Jose Carlos Pastor1,2 1Universidad de Valladolid, Instituto Universitario de Oftalmobiología Aplicada (IOBA Eye Institute), Valladolid, 47011, Spain; 2Hospital Clínico Universitario, Department of Ophthalmology, Valladolid, 47005, Spain; 3Universidad de Valladolid, Departamento de Física Teórica, Atómica y Óptica, Valladolid, 47011, Spain; 4Plymouth University, Faculty of Health and Human Sciences, Plymouth, UK; 5Hospital Clínico Universitario, Department of Neurology, Valladolid, 47005, SpainCorrespondence: Raul MartinIOBA Eye Institute, University of Valladolid, Paseo de Belen, 17, Valladolid, 47011, SpainTel +34 983 184 848Fax +34 983 184 762Email raul@ioba.med.uva.esObjective: To evaluate the agreement between the peripapillary retinal nerve fiber layer (pRNFL) and foveal thickness (FT) measurements among three different spectral domain-optical coherence tomography (SD-OCT) instruments in a sample of multiple sclerosis (MS) patients and a healthy age-matched control group.Methods: An observational cross-sectional study with three groups: healthy subjects and MS patients w/w a previous clinical diagnosis of optic neuritis (ON) was conducted. The pRNFL and FT were measured using three different SD-OCT instruments (OCT PRIMUS 200 and OCT CIRRUS 500 SD-OCT [Carl Zeiss Meditec] and OCT 3D 2000 [Topcon]).Results: Twenty eyes from 10 healthy subjects matched in age with MS patients without a previous history of eye disease and 62 MS eyes from 31 MS patients (29 eyes without history of ON and 33 eyes with history of ON) were enrolled. Healthy subjects and MS patients without ON did not show differences between the pRNFL and FT thickness (P> 0.99) with any of the instruments. However, MS eyes with a previous episode of ON showed thinner pRNFL and FT (P< 0.01). PRIMUS and CIRRUS OCT showed better agreement of the pRNLF and FT in both healthy and MS eyes. However, 3D OCT showed less agreement in the pRNFL measurement with CIRRUS in both healthy and MS eyes.Interpretation: Although OCT is a valuable technology to improve MS patient assessment, differences between devices must be taken into account. It is necessary to create an international group that standardizes the measurement conditions and above all that provides reference bases for normal subjects.Keywords: spectral-domain optical coherence tomography; SD-OCT, multiple sclerosis; MS, retinal nerve fiber layer; RNFL, foveal thickness; FT, variability
format	article
author	Para-Prieto M Martin R Crespo S Mena-Garcia L Valisena A Cordero L Gonzalez Fernandez G Arenillas JF Tellez N Pastor JC
author_facet	Para-Prieto M Martin R Crespo S Mena-Garcia L Valisena A Cordero L Gonzalez Fernandez G Arenillas JF Tellez N Pastor JC
author_sort	Para-Prieto M
title	OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis
title_short	OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis
title_full	OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis
title_fullStr	OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis
title_full_unstemmed	OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis
title_sort	oct variability prevents their use as robust biomarkers in multiple sclerosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4a0e56c51ffe4e95b2ce163c33ec0b6b
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OCT Variability Prevents Their Use as Robust Biomarkers in Multiple Sclerosis

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