Malonylation of GAPDH is an inflammatory signal in macrophages

Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulating both its enzymatic activity and RNA-binding capa...

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Autores principales:	Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a
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spelling	oai:doaj.org-article:4a15ae022f184e95bae97dad5d2e7a5a2021-12-02T15:35:49ZMalonylation of GAPDH is an inflammatory signal in macrophages10.1038/s41467-018-08187-62041-1723https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08187-6https://doaj.org/toc/2041-1723Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulating both its enzymatic activity and RNA-binding capacity.Silvia Galván-PeñaRichard G. CarrollCarla NewmanElizabeth C. HinchyEva Palsson-McDermottElektra K. RobinsonSergio CovarrubiasAlan NadinAndrew M. JamesMoritz HaneklausSusan CarpenterVincent P. KellyMichael P. MurphyLouise K. ModisLuke A. O’NeillNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Galván-Peña Richard G. Carroll Carla Newman Elizabeth C. Hinchy Eva Palsson-McDermott Elektra K. Robinson Sergio Covarrubias Alan Nadin Andrew M. James Moritz Haneklaus Susan Carpenter Vincent P. Kelly Michael P. Murphy Louise K. Modis Luke A. O’Neill Malonylation of GAPDH is an inflammatory signal in macrophages
description	Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulating both its enzymatic activity and RNA-binding capacity.
format	article
author	Silvia Galván-Peña Richard G. Carroll Carla Newman Elizabeth C. Hinchy Eva Palsson-McDermott Elektra K. Robinson Sergio Covarrubias Alan Nadin Andrew M. James Moritz Haneklaus Susan Carpenter Vincent P. Kelly Michael P. Murphy Louise K. Modis Luke A. O’Neill
author_facet	Silvia Galván-Peña Richard G. Carroll Carla Newman Elizabeth C. Hinchy Eva Palsson-McDermott Elektra K. Robinson Sergio Covarrubias Alan Nadin Andrew M. James Moritz Haneklaus Susan Carpenter Vincent P. Kelly Michael P. Murphy Louise K. Modis Luke A. O’Neill
author_sort	Silvia Galván-Peña
title	Malonylation of GAPDH is an inflammatory signal in macrophages
title_short	Malonylation of GAPDH is an inflammatory signal in macrophages
title_full	Malonylation of GAPDH is an inflammatory signal in macrophages
title_fullStr	Malonylation of GAPDH is an inflammatory signal in macrophages
title_full_unstemmed	Malonylation of GAPDH is an inflammatory signal in macrophages
title_sort	malonylation of gapdh is an inflammatory signal in macrophages
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a
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Malonylation of GAPDH is an inflammatory signal in macrophages

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