Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.

<h4>Introduction</h4>Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity. Magnetic Resonance Elastography (MRE) is a novel technique that directly visualizes and quantitatively measures biomechanical tissue properties in...

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Autores principales:	Kaspar-Josche Streitberger, Ingolf Sack, Dagmar Krefting, Caspar Pfüller, Jürgen Braun, Friedemann Paul, Jens Wuerfel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a191ebd8dd94c59b4ebb5391db4cdfa
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spelling	oai:doaj.org-article:4a191ebd8dd94c59b4ebb5391db4cdfa2021-11-18T07:29:45ZBrain viscoelasticity alteration in chronic-progressive multiple sclerosis.1932-620310.1371/journal.pone.0029888https://doaj.org/article/4a191ebd8dd94c59b4ebb5391db4cdfa2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22276134/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity. Magnetic Resonance Elastography (MRE) is a novel technique that directly visualizes and quantitatively measures biomechanical tissue properties in vivo. MRE recently revealed that early relapsing-remitting multiple sclerosis (MS) is associated with a global decrease of the cerebral mechanical integrity. This study addresses MRE and MR volumetry in chronic-progressive disease courses of MS.<h4>Methods</h4>We determined viscoelastic parameters of the brain parenchyma in 23 MS patients with primary or secondary chronic progressive disease course in comparison to 38 age- and gender-matched healthy individuals by multifrequency MRE, and correlated the results with clinical data, T2 lesion load and brain volume. Two viscoelastic parameters, the shear elasticity μ and the powerlaw exponent α, were deduced according to the springpot model and compared to literature values of relapsing-remitting MS.<h4>Results</h4>In chronic-progressive MS patients, μ and α were reduced by 20.5% and 6.1%, respectively, compared to healthy controls. MR volumetry yielded a weaker correlation: Total brain volume loss in MS patients was in the range of 7.5% and 1.7% considering the brain parenchymal fraction. All findings were significant (P<0.001).<h4>Conclusions</h4>Chronic-progressive MS disease courses show a pronounced reduction of the cerebral shear elasticity compared to early relapsing-remitting disease. The powerlaw exponent α decreased only in the chronic-progressive stage of MS, suggesting an alteration in the geometry of the cerebral mechanical network due to chronic neuroinflammation.Kaspar-Josche StreitbergerIngolf SackDagmar KreftingCaspar PfüllerJürgen BraunFriedemann PaulJens WuerfelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29888 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaspar-Josche Streitberger Ingolf Sack Dagmar Krefting Caspar Pfüller Jürgen Braun Friedemann Paul Jens Wuerfel Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
description	<h4>Introduction</h4>Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity. Magnetic Resonance Elastography (MRE) is a novel technique that directly visualizes and quantitatively measures biomechanical tissue properties in vivo. MRE recently revealed that early relapsing-remitting multiple sclerosis (MS) is associated with a global decrease of the cerebral mechanical integrity. This study addresses MRE and MR volumetry in chronic-progressive disease courses of MS.<h4>Methods</h4>We determined viscoelastic parameters of the brain parenchyma in 23 MS patients with primary or secondary chronic progressive disease course in comparison to 38 age- and gender-matched healthy individuals by multifrequency MRE, and correlated the results with clinical data, T2 lesion load and brain volume. Two viscoelastic parameters, the shear elasticity μ and the powerlaw exponent α, were deduced according to the springpot model and compared to literature values of relapsing-remitting MS.<h4>Results</h4>In chronic-progressive MS patients, μ and α were reduced by 20.5% and 6.1%, respectively, compared to healthy controls. MR volumetry yielded a weaker correlation: Total brain volume loss in MS patients was in the range of 7.5% and 1.7% considering the brain parenchymal fraction. All findings were significant (P<0.001).<h4>Conclusions</h4>Chronic-progressive MS disease courses show a pronounced reduction of the cerebral shear elasticity compared to early relapsing-remitting disease. The powerlaw exponent α decreased only in the chronic-progressive stage of MS, suggesting an alteration in the geometry of the cerebral mechanical network due to chronic neuroinflammation.
format	article
author	Kaspar-Josche Streitberger Ingolf Sack Dagmar Krefting Caspar Pfüller Jürgen Braun Friedemann Paul Jens Wuerfel
author_facet	Kaspar-Josche Streitberger Ingolf Sack Dagmar Krefting Caspar Pfüller Jürgen Braun Friedemann Paul Jens Wuerfel
author_sort	Kaspar-Josche Streitberger
title	Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
title_short	Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
title_full	Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
title_fullStr	Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
title_full_unstemmed	Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
title_sort	brain viscoelasticity alteration in chronic-progressive multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4a191ebd8dd94c59b4ebb5391db4cdfa
work_keys_str_mv	AT kasparjoschestreitberger brainviscoelasticityalterationinchronicprogressivemultiplesclerosis AT ingolfsack brainviscoelasticityalterationinchronicprogressivemultiplesclerosis AT dagmarkrefting brainviscoelasticityalterationinchronicprogressivemultiplesclerosis AT casparpfuller brainviscoelasticityalterationinchronicprogressivemultiplesclerosis AT jurgenbraun brainviscoelasticityalterationinchronicprogressivemultiplesclerosis AT friedemannpaul brainviscoelasticityalterationinchronicprogressivemultiplesclerosis AT jenswuerfel brainviscoelasticityalterationinchronicprogressivemultiplesclerosis
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Brain viscoelasticity alteration in chronic-progressive multiple sclerosis.

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