Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio

The initiation of prey invasion by the predatory bacterium Bdellovibrio bacteriovorus is governed by the activity of the diguanlylate cyclase DgcB. Here the authors show that the stimulus regulating DgcB activity is a phosphopeptide derived from DgcB itself and present the crystal structures of full...

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Autores principales:	Richard W. Meek, Ian T. Cadby, Patrick J. Moynihan, Andrew L. Lovering
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a1bc9ed1efc47e99221f62e5470fb68
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spelling	oai:doaj.org-article:4a1bc9ed1efc47e99221f62e5470fb682021-12-02T17:31:21ZStructural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio10.1038/s41467-019-12051-62041-1723https://doaj.org/article/4a1bc9ed1efc47e99221f62e5470fb682019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12051-6https://doaj.org/toc/2041-1723The initiation of prey invasion by the predatory bacterium Bdellovibrio bacteriovorus is governed by the activity of the diguanlylate cyclase DgcB. Here the authors show that the stimulus regulating DgcB activity is a phosphopeptide derived from DgcB itself and present the crystal structures of full-length DgcB and of its empty and peptide-bound sensor domain.Richard W. MeekIan T. CadbyPatrick J. MoynihanAndrew L. LoveringNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Richard W. Meek Ian T. Cadby Patrick J. Moynihan Andrew L. Lovering Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio
description	The initiation of prey invasion by the predatory bacterium Bdellovibrio bacteriovorus is governed by the activity of the diguanlylate cyclase DgcB. Here the authors show that the stimulus regulating DgcB activity is a phosphopeptide derived from DgcB itself and present the crystal structures of full-length DgcB and of its empty and peptide-bound sensor domain.
format	article
author	Richard W. Meek Ian T. Cadby Patrick J. Moynihan Andrew L. Lovering
author_facet	Richard W. Meek Ian T. Cadby Patrick J. Moynihan Andrew L. Lovering
author_sort	Richard W. Meek
title	Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio
title_short	Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio
title_full	Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio
title_fullStr	Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio
title_full_unstemmed	Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio
title_sort	structural basis for activation of a diguanylate cyclase required for bacterial predation in bdellovibrio
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4a1bc9ed1efc47e99221f62e5470fb68
work_keys_str_mv	AT richardwmeek structuralbasisforactivationofadiguanylatecyclaserequiredforbacterialpredationinbdellovibrio AT iantcadby structuralbasisforactivationofadiguanylatecyclaserequiredforbacterialpredationinbdellovibrio AT patrickjmoynihan structuralbasisforactivationofadiguanylatecyclaserequiredforbacterialpredationinbdellovibrio AT andrewllovering structuralbasisforactivationofadiguanylatecyclaserequiredforbacterialpredationinbdellovibrio
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Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio

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