LKB1 mediates the development of conventional and innate T cells via AMP-dependent kinase autonomous pathways.
The present study has examined the role of the serine/threonine kinase LKB1 in the survival and differentiation of CD4/8 double positive thymocytes. LKB1-null DPs can respond to signals from the mature α/β T-cell-antigen receptor and initiate positive selection. However, in the absence of LKB1, thym...
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Auteurs principaux: | Marouan Zarrouk, Julia Rolf, Doreen Ann Cantrell |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2013
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Accès en ligne: | https://doaj.org/article/4a1df02b4d2f424dbe550c009ce3c3a9 |
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