Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice

Marzieh Salimi,1,2 Saeed Sarkar,1,2 Samaneh Fathi,3 Ali Mohammad Alizadeh,4 Reza Saber,2,3 Fatemeh Moradi,5 Hamid Delavari6 1Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran; 2Research Center of Science and Technology in Medicine, Tehran...

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Autores principales:	Salimi M, Sarkar S, Fathi S, Alizadeh AM, Saber R, Moradi F, Delavari H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	G4@IONPs Biodistribution Pharmacokinetics Toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4a1f83fa5f9540fd868d13cc77607236
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spelling	oai:doaj.org-article:4a1f83fa5f9540fd868d13cc776072362021-12-02T05:39:37ZBiodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice1178-2013https://doaj.org/article/4a1f83fa5f9540fd868d13cc776072362018-03-01T00:00:00Zhttps://www.dovepress.com/biodistribution-pharmacokinetics-and-toxicity-of-dendrimer-coated-iron-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Marzieh Salimi,1,2 Saeed Sarkar,1,2 Samaneh Fathi,3 Ali Mohammad Alizadeh,4 Reza Saber,2,3 Fatemeh Moradi,5 Hamid Delavari6 1Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran; 2Research Center of Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Medical Nanotechnology, Tehran University of Medical Sciences, Tehran, Iran; 4Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Medical Physiology, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Materials Science and Engineering, Tarbiat Modares University, Tehran, Iran Background: The possibility of using a specific nanoparticle in nanomedicine highly depends on its biodistribution profile and biocompatibility. Due to growing demand for iron oxide nanoparticles (IONPs) and dendrimers in biomedical applications, this study was performed to assess the biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles (G4@IONPs). Materials and methods: IONPs were synthesized via co-precipitation and coated with the fourth generation (G4) of polyamidoamine (PAMAM) dendrimer. To determine the biodistribution, 5 mg/mL G4@IONPs suspension was intraperitoneally injected into tumor-bearing BALB/c mice, and iron levels in blood and various organs, including the lung, liver, brain, heart, tumor, and kidney, were measured by inductively coupled plasma mass spectrometry (ICP-MS) at 4, 8, 12, and 24 h after injection. Also, to investigate the toxicity of G4@IONPs, different concentrations of G4@IONPs were injected into BALB/c mice, and blood, renal, and hepatic factors were measured. Furthermore, histopathological staining was performed to investigate the effect of G4@IONPs on the liver and kidney tissues. Results: The results showed that the iron content was higher in the kidney, liver, and lung tissues 24 h after injection. Toxicity assessments revealed a significant increase in blood urea nitrogen (BUN) and direct bilirubin at the concentration of 10 mg/kg. Also, in this concentration, histopathological abnormalities were detected in liver tissue. Conclusion: Although more systematic studies are still required, our results encouraged the future investigations of G4@IONPs in biomedical applications. Keywords: G4@IONPs, biodistribution, pharmacokinetics, toxicitySalimi MSarkar SFathi SAlizadeh AMSaber RMoradi FDelavari HDove Medical PressarticleG4@IONPsBiodistributionPharmacokineticsToxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1483-1493 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	G4@IONPs Biodistribution Pharmacokinetics Toxicity Medicine (General) R5-920
spellingShingle	G4@IONPs Biodistribution Pharmacokinetics Toxicity Medicine (General) R5-920 Salimi M Sarkar S Fathi S Alizadeh AM Saber R Moradi F Delavari H Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice
description	Marzieh Salimi,1,2 Saeed Sarkar,1,2 Samaneh Fathi,3 Ali Mohammad Alizadeh,4 Reza Saber,2,3 Fatemeh Moradi,5 Hamid Delavari6 1Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran; 2Research Center of Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Medical Nanotechnology, Tehran University of Medical Sciences, Tehran, Iran; 4Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Medical Physiology, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Materials Science and Engineering, Tarbiat Modares University, Tehran, Iran Background: The possibility of using a specific nanoparticle in nanomedicine highly depends on its biodistribution profile and biocompatibility. Due to growing demand for iron oxide nanoparticles (IONPs) and dendrimers in biomedical applications, this study was performed to assess the biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles (G4@IONPs). Materials and methods: IONPs were synthesized via co-precipitation and coated with the fourth generation (G4) of polyamidoamine (PAMAM) dendrimer. To determine the biodistribution, 5 mg/mL G4@IONPs suspension was intraperitoneally injected into tumor-bearing BALB/c mice, and iron levels in blood and various organs, including the lung, liver, brain, heart, tumor, and kidney, were measured by inductively coupled plasma mass spectrometry (ICP-MS) at 4, 8, 12, and 24 h after injection. Also, to investigate the toxicity of G4@IONPs, different concentrations of G4@IONPs were injected into BALB/c mice, and blood, renal, and hepatic factors were measured. Furthermore, histopathological staining was performed to investigate the effect of G4@IONPs on the liver and kidney tissues. Results: The results showed that the iron content was higher in the kidney, liver, and lung tissues 24 h after injection. Toxicity assessments revealed a significant increase in blood urea nitrogen (BUN) and direct bilirubin at the concentration of 10 mg/kg. Also, in this concentration, histopathological abnormalities were detected in liver tissue. Conclusion: Although more systematic studies are still required, our results encouraged the future investigations of G4@IONPs in biomedical applications. Keywords: G4@IONPs, biodistribution, pharmacokinetics, toxicity
format	article
author	Salimi M Sarkar S Fathi S Alizadeh AM Saber R Moradi F Delavari H
author_facet	Salimi M Sarkar S Fathi S Alizadeh AM Saber R Moradi F Delavari H
author_sort	Salimi M
title	Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice
title_short	Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice
title_full	Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice
title_fullStr	Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice
title_full_unstemmed	Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice
title_sort	biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in balb/c mice
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/4a1f83fa5f9540fd868d13cc77607236
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Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice

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