Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge

Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses infecting human epithelial cells, are associated with various benign and malignant lesions of mucosa and skin. Intensive research on the oncogenic potential of HPVs started in the 1970s and spread across Europe, in...

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Autores principales:	Ena Pešut, Anamaria Đukić, Lucija Lulić, Josipa Skelin, Ivana Šimić, Nina Milutin Gašperov, Vjekoslav Tomaić, Ivan Sabol, Magdalena Grce
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human papillomaviruses (HPV) oncoproteins proteomics epigenetics biomarkers cancer Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4a207d0516cb4b708d43cf68ad57bccd
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spelling	oai:doaj.org-article:4a207d0516cb4b708d43cf68ad57bccd2021-11-25T19:13:36ZHuman Papillomaviruses-Associated Cancers: An Update of Current Knowledge10.3390/v131122341999-4915https://doaj.org/article/4a207d0516cb4b708d43cf68ad57bccd2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2234https://doaj.org/toc/1999-4915Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses infecting human epithelial cells, are associated with various benign and malignant lesions of mucosa and skin. Intensive research on the oncogenic potential of HPVs started in the 1970s and spread across Europe, including Croatia, and worldwide. Nowadays, the causative role of a subset of oncogenic or high-risk (HR) HPV types, led by HPV-16 and HPV-18, of different anogenital and head and neck cancers is well accepted. Two major viral oncoproteins, E6 and E7, are directly involved in the development of HPV-related malignancies by targeting synergistically various cellular pathways involved in the regulation of cell cycle control, apoptosis, and cell polarity control networks as well as host immune response. This review is aimed at describing the key elements in HPV-related carcinogenesis and the advances in cancer prevention with reference to past and on-going research in Croatia.Ena PešutAnamaria ĐukićLucija LulićJosipa SkelinIvana ŠimićNina Milutin GašperovVjekoslav TomaićIvan SabolMagdalena GrceMDPI AGarticlehuman papillomaviruses (HPV)oncoproteinsproteomicsepigeneticsbiomarkerscancerMicrobiologyQR1-502ENViruses, Vol 13, Iss 2234, p 2234 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human papillomaviruses (HPV) oncoproteins proteomics epigenetics biomarkers cancer Microbiology QR1-502
spellingShingle	human papillomaviruses (HPV) oncoproteins proteomics epigenetics biomarkers cancer Microbiology QR1-502 Ena Pešut Anamaria Đukić Lucija Lulić Josipa Skelin Ivana Šimić Nina Milutin Gašperov Vjekoslav Tomaić Ivan Sabol Magdalena Grce Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge
description	Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses infecting human epithelial cells, are associated with various benign and malignant lesions of mucosa and skin. Intensive research on the oncogenic potential of HPVs started in the 1970s and spread across Europe, including Croatia, and worldwide. Nowadays, the causative role of a subset of oncogenic or high-risk (HR) HPV types, led by HPV-16 and HPV-18, of different anogenital and head and neck cancers is well accepted. Two major viral oncoproteins, E6 and E7, are directly involved in the development of HPV-related malignancies by targeting synergistically various cellular pathways involved in the regulation of cell cycle control, apoptosis, and cell polarity control networks as well as host immune response. This review is aimed at describing the key elements in HPV-related carcinogenesis and the advances in cancer prevention with reference to past and on-going research in Croatia.
format	article
author	Ena Pešut Anamaria Đukić Lucija Lulić Josipa Skelin Ivana Šimić Nina Milutin Gašperov Vjekoslav Tomaić Ivan Sabol Magdalena Grce
author_facet	Ena Pešut Anamaria Đukić Lucija Lulić Josipa Skelin Ivana Šimić Nina Milutin Gašperov Vjekoslav Tomaić Ivan Sabol Magdalena Grce
author_sort	Ena Pešut
title	Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge
title_short	Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge
title_full	Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge
title_fullStr	Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge
title_full_unstemmed	Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge
title_sort	human papillomaviruses-associated cancers: an update of current knowledge
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4a207d0516cb4b708d43cf68ad57bccd
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Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge

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