Cinnamon induces browning in subcutaneous adipocytes

Abstract Browning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browni...

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Autores principales:	Hiu Yee Kwan, Jiahui Wu, Tao Su, Xiao-Juan Chao, Bin Liu, Xiuqiong Fu, Chi Leung Chan, Rebecca Hiu Ying Lau, Anfernee Kai Wing Tse, Quan Bin Han, Wang Fun Fong, Zhi-ling Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a2139234e8c47f09b6daba08c0beffb
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spelling	oai:doaj.org-article:4a2139234e8c47f09b6daba08c0beffb2021-12-02T15:05:28ZCinnamon induces browning in subcutaneous adipocytes10.1038/s41598-017-02263-52045-2322https://doaj.org/article/4a2139234e8c47f09b6daba08c0beffb2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02263-5https://doaj.org/toc/2045-2322Abstract Browning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browning effect of cinnamon extract. We found that cinnamon extract (CE) induced typical brown adipocyte multiocular phenotype in 3T3-L1 adipocytes. The treatment also increased brown adipocytes markers and reduced white adipocytes markers in the 3T3-L1 adipocytes. In ex vivo studies, we found that CE increased brown adipocytes markers in the subcutaneous adipocytes isolated from db/db mice and diet-induced obesity (DIO) mice. However, CE did not significantly affect UCP1 expression in the adipocytes isolated from perinephric adipose tissue and epididymal adipose tissue. β3-adernergic receptor (β3-AR) antagonist reduced the CE-enhanced UCP1 expression, suggesting an involvement of the β3-AR activity. Oral administration of CE significantly increased UCP1 expression in the subcutaneous adipose tissue in vivo and reduced the body weight of the DIO mice. Taken together, our data suggest that CE has a browning effect in subcutaneous adipocytes. Our study suggests a natural non-toxic herbal remedy to reduce obesity.Hiu Yee KwanJiahui WuTao SuXiao-Juan ChaoBin LiuXiuqiong FuChi Leung ChanRebecca Hiu Ying LauAnfernee Kai Wing TseQuan Bin HanWang Fun FongZhi-ling YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiu Yee Kwan Jiahui Wu Tao Su Xiao-Juan Chao Bin Liu Xiuqiong Fu Chi Leung Chan Rebecca Hiu Ying Lau Anfernee Kai Wing Tse Quan Bin Han Wang Fun Fong Zhi-ling Yu Cinnamon induces browning in subcutaneous adipocytes
description	Abstract Browning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browning effect of cinnamon extract. We found that cinnamon extract (CE) induced typical brown adipocyte multiocular phenotype in 3T3-L1 adipocytes. The treatment also increased brown adipocytes markers and reduced white adipocytes markers in the 3T3-L1 adipocytes. In ex vivo studies, we found that CE increased brown adipocytes markers in the subcutaneous adipocytes isolated from db/db mice and diet-induced obesity (DIO) mice. However, CE did not significantly affect UCP1 expression in the adipocytes isolated from perinephric adipose tissue and epididymal adipose tissue. β3-adernergic receptor (β3-AR) antagonist reduced the CE-enhanced UCP1 expression, suggesting an involvement of the β3-AR activity. Oral administration of CE significantly increased UCP1 expression in the subcutaneous adipose tissue in vivo and reduced the body weight of the DIO mice. Taken together, our data suggest that CE has a browning effect in subcutaneous adipocytes. Our study suggests a natural non-toxic herbal remedy to reduce obesity.
format	article
author	Hiu Yee Kwan Jiahui Wu Tao Su Xiao-Juan Chao Bin Liu Xiuqiong Fu Chi Leung Chan Rebecca Hiu Ying Lau Anfernee Kai Wing Tse Quan Bin Han Wang Fun Fong Zhi-ling Yu
author_facet	Hiu Yee Kwan Jiahui Wu Tao Su Xiao-Juan Chao Bin Liu Xiuqiong Fu Chi Leung Chan Rebecca Hiu Ying Lau Anfernee Kai Wing Tse Quan Bin Han Wang Fun Fong Zhi-ling Yu
author_sort	Hiu Yee Kwan
title	Cinnamon induces browning in subcutaneous adipocytes
title_short	Cinnamon induces browning in subcutaneous adipocytes
title_full	Cinnamon induces browning in subcutaneous adipocytes
title_fullStr	Cinnamon induces browning in subcutaneous adipocytes
title_full_unstemmed	Cinnamon induces browning in subcutaneous adipocytes
title_sort	cinnamon induces browning in subcutaneous adipocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4a2139234e8c47f09b6daba08c0beffb
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_version_	1718388827562704896

Cinnamon induces browning in subcutaneous adipocytes

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