TNIK inhibition abrogates colorectal cancer stemness

TNIK inhibition abrogates colorectal cancer stemness

TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice.

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Autores principales: Mari Masuda, Yuko Uno, Naomi Ohbayashi, Hirokazu Ohata, Ayako Mimata, Mutsuko Kukimoto-Niino, Hideki Moriyama, Shigeki Kashimoto, Tomoko Inoue, Naoko Goto, Koji Okamoto, Mikako Shirouzu, Masaaki Sawa, Tesshi Yamada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4a216298e0fc4be591ff7743d3af46e1
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spelling oai:doaj.org-article:4a216298e0fc4be591ff7743d3af46e12021-12-02T15:35:20ZTNIK inhibition abrogates colorectal cancer stemness10.1038/ncomms125862041-1723https://doaj.org/article/4a216298e0fc4be591ff7743d3af46e12016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12586https://doaj.org/toc/2041-1723TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice.Mari MasudaYuko UnoNaomi OhbayashiHirokazu OhataAyako MimataMutsuko Kukimoto-NiinoHideki MoriyamaShigeki KashimotoTomoko InoueNaoko GotoKoji OkamotoMikako ShirouzuMasaaki SawaTesshi YamadaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mari Masuda
Yuko Uno
Naomi Ohbayashi
Hirokazu Ohata
Ayako Mimata
Mutsuko Kukimoto-Niino
Hideki Moriyama
Shigeki Kashimoto
Tomoko Inoue
Naoko Goto
Koji Okamoto
Mikako Shirouzu
Masaaki Sawa
Tesshi Yamada
TNIK inhibition abrogates colorectal cancer stemness
description TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice.
format article
author Mari Masuda
Yuko Uno
Naomi Ohbayashi
Hirokazu Ohata
Ayako Mimata
Mutsuko Kukimoto-Niino
Hideki Moriyama
Shigeki Kashimoto
Tomoko Inoue
Naoko Goto
Koji Okamoto
Mikako Shirouzu
Masaaki Sawa
Tesshi Yamada
author_facet Mari Masuda
Yuko Uno
Naomi Ohbayashi
Hirokazu Ohata
Ayako Mimata
Mutsuko Kukimoto-Niino
Hideki Moriyama
Shigeki Kashimoto
Tomoko Inoue
Naoko Goto
Koji Okamoto
Mikako Shirouzu
Masaaki Sawa
Tesshi Yamada
author_sort Mari Masuda
title TNIK inhibition abrogates colorectal cancer stemness
title_short TNIK inhibition abrogates colorectal cancer stemness
title_full TNIK inhibition abrogates colorectal cancer stemness
title_fullStr TNIK inhibition abrogates colorectal cancer stemness
title_full_unstemmed TNIK inhibition abrogates colorectal cancer stemness
title_sort tnik inhibition abrogates colorectal cancer stemness
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/4a216298e0fc4be591ff7743d3af46e1
work_keys_str_mv AT marimasuda tnikinhibitionabrogatescolorectalcancerstemness
AT yukouno tnikinhibitionabrogatescolorectalcancerstemness
AT naomiohbayashi tnikinhibitionabrogatescolorectalcancerstemness
AT hirokazuohata tnikinhibitionabrogatescolorectalcancerstemness
AT ayakomimata tnikinhibitionabrogatescolorectalcancerstemness
AT mutsukokukimotoniino tnikinhibitionabrogatescolorectalcancerstemness
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AT tomokoinoue tnikinhibitionabrogatescolorectalcancerstemness
AT naokogoto tnikinhibitionabrogatescolorectalcancerstemness
AT kojiokamoto tnikinhibitionabrogatescolorectalcancerstemness
AT mikakoshirouzu tnikinhibitionabrogatescolorectalcancerstemness
AT masaakisawa tnikinhibitionabrogatescolorectalcancerstemness
AT tesshiyamada tnikinhibitionabrogatescolorectalcancerstemness
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