Automated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning
ObjectivesThis study was conducted in order to design and develop a framework utilizing deep learning (DL) to differentiate papillary renal cell carcinoma (PRCC) from chromophobe renal cell carcinoma (ChRCC) using convolutional neural networks (CNNs) on a small set of computed tomography (CT) images...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:4a27e8cc978748b0a4b88c65b8b0753b2021-11-18T10:37:59ZAutomated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning2234-943X10.3389/fonc.2021.746750https://doaj.org/article/4a27e8cc978748b0a4b88c65b8b0753b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.746750/fullhttps://doaj.org/toc/2234-943XObjectivesThis study was conducted in order to design and develop a framework utilizing deep learning (DL) to differentiate papillary renal cell carcinoma (PRCC) from chromophobe renal cell carcinoma (ChRCC) using convolutional neural networks (CNNs) on a small set of computed tomography (CT) images and provide a feasible method that can be applied to light devices.MethodsTraining and validation datasets were established based on radiological, clinical, and pathological data exported from the radiology, urology, and pathology departments. As the gold standard, reports were reviewed to determine the pathological subtype. Six CNN-based models were trained and validated to differentiate the two subtypes. A special test dataset generated with six new cases and four cases from The Cancer Imaging Archive (TCIA) was applied to validate the efficiency of the best model and of the manual processing by abdominal radiologists. Objective evaluation indexes [accuracy, sensitivity, specificity, receiver operating characteristic (ROC) curve, and area under the curve (AUC)] were calculated to assess model performance.ResultsThe CT image sequences of 70 patients were segmented and validated by two experienced abdominal radiologists. The best model achieved 96.8640% accuracy (99.3794% sensitivity and 94.0271% specificity) in the validation set and 100% (case accuracy) and 93.3333% (image accuracy) in the test set. The manual classification achieved 85% accuracy (100% sensitivity and 70% specificity) in the test set.ConclusionsThis framework demonstrates that DL models could help reliably predict the subtypes of PRCC and ChRCC.Teng ZuoYanhua ZhengLingfeng HeTao ChenBin ZhengSong ZhengJinghang YouXiaoyan LiRong LiuJunjie BaiShuxin SiYingying WangShuyi ZhangLili WangJianhui ChenFrontiers Media S.A.articleCNN—convolutional neural networkPRCCpapillary renal cell carcinomaChRCC,·chromophobe-primary renal cell carcinomacancer image classificationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
CNN—convolutional neural network PRCC papillary renal cell carcinoma ChRCC,·chromophobe-primary renal cell carcinoma cancer image classification Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
CNN—convolutional neural network PRCC papillary renal cell carcinoma ChRCC,·chromophobe-primary renal cell carcinoma cancer image classification Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Teng Zuo Yanhua Zheng Lingfeng He Tao Chen Bin Zheng Song Zheng Jinghang You Xiaoyan Li Rong Liu Junjie Bai Shuxin Si Yingying Wang Shuyi Zhang Lili Wang Jianhui Chen Automated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning |
| description |
ObjectivesThis study was conducted in order to design and develop a framework utilizing deep learning (DL) to differentiate papillary renal cell carcinoma (PRCC) from chromophobe renal cell carcinoma (ChRCC) using convolutional neural networks (CNNs) on a small set of computed tomography (CT) images and provide a feasible method that can be applied to light devices.MethodsTraining and validation datasets were established based on radiological, clinical, and pathological data exported from the radiology, urology, and pathology departments. As the gold standard, reports were reviewed to determine the pathological subtype. Six CNN-based models were trained and validated to differentiate the two subtypes. A special test dataset generated with six new cases and four cases from The Cancer Imaging Archive (TCIA) was applied to validate the efficiency of the best model and of the manual processing by abdominal radiologists. Objective evaluation indexes [accuracy, sensitivity, specificity, receiver operating characteristic (ROC) curve, and area under the curve (AUC)] were calculated to assess model performance.ResultsThe CT image sequences of 70 patients were segmented and validated by two experienced abdominal radiologists. The best model achieved 96.8640% accuracy (99.3794% sensitivity and 94.0271% specificity) in the validation set and 100% (case accuracy) and 93.3333% (image accuracy) in the test set. The manual classification achieved 85% accuracy (100% sensitivity and 70% specificity) in the test set.ConclusionsThis framework demonstrates that DL models could help reliably predict the subtypes of PRCC and ChRCC. |
| format |
article |
| author |
Teng Zuo Yanhua Zheng Lingfeng He Tao Chen Bin Zheng Song Zheng Jinghang You Xiaoyan Li Rong Liu Junjie Bai Shuxin Si Yingying Wang Shuyi Zhang Lili Wang Jianhui Chen |
| author_facet |
Teng Zuo Yanhua Zheng Lingfeng He Tao Chen Bin Zheng Song Zheng Jinghang You Xiaoyan Li Rong Liu Junjie Bai Shuxin Si Yingying Wang Shuyi Zhang Lili Wang Jianhui Chen |
| author_sort |
Teng Zuo |
| title |
Automated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning |
| title_short |
Automated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning |
| title_full |
Automated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning |
| title_fullStr |
Automated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning |
| title_full_unstemmed |
Automated Classification of Papillary Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma Based on a Small Computed Tomography Imaging Dataset Using Deep Learning |
| title_sort |
automated classification of papillary renal cell carcinoma and chromophobe renal cell carcinoma based on a small computed tomography imaging dataset using deep learning |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/4a27e8cc978748b0a4b88c65b8b0753b |
| work_keys_str_mv |
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