Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants

Abstract Literature supports an association between transfusions and gut injury in preterm infants. We hypothesized that packed red blood (PRBC) transfusions are associated with kidney inflammation marked by a rise in urinary levels of Kidney Injury Molecule 1 (KIM-1). Prospectively, KIM-1 levels we...

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Autores principales:	Stephanie S. Turner, Jennifer M. Davidson, Mohamad T. Elabiad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a28394cd8c04b36b7313ab54ccd9be6
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spelling	oai:doaj.org-article:4a28394cd8c04b36b7313ab54ccd9be62021-12-02T18:25:05ZChanges in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants10.1038/s41598-021-91209-z2045-2322https://doaj.org/article/4a28394cd8c04b36b7313ab54ccd9be62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91209-zhttps://doaj.org/toc/2045-2322Abstract Literature supports an association between transfusions and gut injury in preterm infants. We hypothesized that packed red blood (PRBC) transfusions are associated with kidney inflammation marked by a rise in urinary levels of Kidney Injury Molecule 1 (KIM-1). Prospectively, KIM-1 levels were measured before and then at 6, 12 and 24 h after a PRBC transfusion. Results are presented as mean (± SD) and median (IQR). Thirty-four infants, birth weight 865 (± 375) g, had higher pretransfusion KIM-1 levels of 2270 (830, 3250) pg/mg than what is normal for age. These were not associated with hematocrit levels. KIM-1 levels peaked between 6 and 12 h after the transfusion. Levels peaked to 3300 (1990, 6830) pg/mg; levels returned to pretransfusion levels of 2240 (1240, 3870) pg/mg by 24 h, p < 0.01. The 24-h post-transfusion KIM-1 levels were similar to pretransfusion levels, p = 0.63. PRBC transfusions in preterm infants are associated with an elevation in urinary KIM-1 levels. The mechanism of this association may be important in studying transfusion associated organ injury. KIM-1, as an inflammatory marker, may be helpful in assessing the effect of different transfusion volumes or in evaluating operational thresholds of anemia in premature infants.Stephanie S. TurnerJennifer M. DavidsonMohamad T. ElabiadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephanie S. Turner Jennifer M. Davidson Mohamad T. Elabiad Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants
description	Abstract Literature supports an association between transfusions and gut injury in preterm infants. We hypothesized that packed red blood (PRBC) transfusions are associated with kidney inflammation marked by a rise in urinary levels of Kidney Injury Molecule 1 (KIM-1). Prospectively, KIM-1 levels were measured before and then at 6, 12 and 24 h after a PRBC transfusion. Results are presented as mean (± SD) and median (IQR). Thirty-four infants, birth weight 865 (± 375) g, had higher pretransfusion KIM-1 levels of 2270 (830, 3250) pg/mg than what is normal for age. These were not associated with hematocrit levels. KIM-1 levels peaked between 6 and 12 h after the transfusion. Levels peaked to 3300 (1990, 6830) pg/mg; levels returned to pretransfusion levels of 2240 (1240, 3870) pg/mg by 24 h, p < 0.01. The 24-h post-transfusion KIM-1 levels were similar to pretransfusion levels, p = 0.63. PRBC transfusions in preterm infants are associated with an elevation in urinary KIM-1 levels. The mechanism of this association may be important in studying transfusion associated organ injury. KIM-1, as an inflammatory marker, may be helpful in assessing the effect of different transfusion volumes or in evaluating operational thresholds of anemia in premature infants.
format	article
author	Stephanie S. Turner Jennifer M. Davidson Mohamad T. Elabiad
author_facet	Stephanie S. Turner Jennifer M. Davidson Mohamad T. Elabiad
author_sort	Stephanie S. Turner
title	Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants
title_short	Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants
title_full	Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants
title_fullStr	Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants
title_full_unstemmed	Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants
title_sort	changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4a28394cd8c04b36b7313ab54ccd9be6
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Changes in urinary kidney injury molecule-1 levels after blood transfusions in preterm infants

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