A systems study reveals concurrent activation of AMPK and mTOR by amino acids
mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ sustains autophagy under non-starvation conditions.
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/4a285de016fb4d67ada2a43c868dc313 |
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oai:doaj.org-article:4a285de016fb4d67ada2a43c868dc3132021-12-02T17:32:07ZA systems study reveals concurrent activation of AMPK and mTOR by amino acids10.1038/ncomms132542041-1723https://doaj.org/article/4a285de016fb4d67ada2a43c868dc3132016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13254https://doaj.org/toc/2041-1723mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ sustains autophagy under non-starvation conditions.Piero Dalle PezzeStefanie RufAnnika G. SonntagMiriam Langelaar-MakkinjePhilip HallAlexander M. HeberlePatricia Razquin NavasKaren van EunenRegine C. TölleJennifer J. SchwarzHeike WieseBettina WarscheidJana DeitersenBjörn StorkErik FäßlerSascha SchäubleUdo HahnPeter HorvatovichDaryl P. ShanleyKathrin ThedieckNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Piero Dalle Pezze Stefanie Ruf Annika G. Sonntag Miriam Langelaar-Makkinje Philip Hall Alexander M. Heberle Patricia Razquin Navas Karen van Eunen Regine C. Tölle Jennifer J. Schwarz Heike Wiese Bettina Warscheid Jana Deitersen Björn Stork Erik Fäßler Sascha Schäuble Udo Hahn Peter Horvatovich Daryl P. Shanley Kathrin Thedieck A systems study reveals concurrent activation of AMPK and mTOR by amino acids |
| description |
mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ sustains autophagy under non-starvation conditions. |
| format |
article |
| author |
Piero Dalle Pezze Stefanie Ruf Annika G. Sonntag Miriam Langelaar-Makkinje Philip Hall Alexander M. Heberle Patricia Razquin Navas Karen van Eunen Regine C. Tölle Jennifer J. Schwarz Heike Wiese Bettina Warscheid Jana Deitersen Björn Stork Erik Fäßler Sascha Schäuble Udo Hahn Peter Horvatovich Daryl P. Shanley Kathrin Thedieck |
| author_facet |
Piero Dalle Pezze Stefanie Ruf Annika G. Sonntag Miriam Langelaar-Makkinje Philip Hall Alexander M. Heberle Patricia Razquin Navas Karen van Eunen Regine C. Tölle Jennifer J. Schwarz Heike Wiese Bettina Warscheid Jana Deitersen Björn Stork Erik Fäßler Sascha Schäuble Udo Hahn Peter Horvatovich Daryl P. Shanley Kathrin Thedieck |
| author_sort |
Piero Dalle Pezze |
| title |
A systems study reveals concurrent activation of AMPK and mTOR by amino acids |
| title_short |
A systems study reveals concurrent activation of AMPK and mTOR by amino acids |
| title_full |
A systems study reveals concurrent activation of AMPK and mTOR by amino acids |
| title_fullStr |
A systems study reveals concurrent activation of AMPK and mTOR by amino acids |
| title_full_unstemmed |
A systems study reveals concurrent activation of AMPK and mTOR by amino acids |
| title_sort |
systems study reveals concurrent activation of ampk and mtor by amino acids |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/4a285de016fb4d67ada2a43c868dc313 |
| work_keys_str_mv |
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| _version_ |
1718380365973815296 |