Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma

Jiaxin Xiao, Xiusheng He Hunan Province Key Laboratory of Tumour Cellular & Molecular Pathology Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang, 421001, Hunan Province, People’s Republic of ChinaCorrespondence: Xiusheng HeHunan Province Key Laboratory o...

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Autores principales:	Xiao J, He X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	mirnas，lncrnas，nasopharyngeal carcinoma，chemo- and radioresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4a2a9e4b094148f2ae64ac8dc18a638f
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spelling	oai:doaj.org-article:4a2a9e4b094148f2ae64ac8dc18a638f2021-11-23T18:43:01ZInvolvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma1179-1322https://doaj.org/article/4a2a9e4b094148f2ae64ac8dc18a638f2021-11-01T00:00:00Zhttps://www.dovepress.com/involvement-of-non-coding-rnas-in-chemo--and-radioresistance-of-nasoph-peer-reviewed-fulltext-article-CMARhttps://doaj.org/toc/1179-1322Jiaxin Xiao, Xiusheng He Hunan Province Key Laboratory of Tumour Cellular & Molecular Pathology Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang, 421001, Hunan Province, People’s Republic of ChinaCorrespondence: Xiusheng HeHunan Province Key Laboratory of Tumour Cellular & Molecular Pathology Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang, 421001, Hunan Province, People’s Republic of ChinaEmail hexiusheng168@163.comAbstract: The crucial treatment for nasopharyngeal carcinoma (NPC) is radiation therapy supplemented by chemotherapy. However, long-term radiation therapy can cause some genetic and proteomic changes to produce radiation resistance, leading to tumour recurrence and poor prognosis. Therefore, the search for new markers that can overcome the resistance of tumor cells to drugs and radiotherapy and improve the sensitivity of tumor cells to drugs and radiotherapy is one of the most important goals of pharmacogenomics and cancer research, which is important for predicting treatment response and prognosis. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), may play important roles in regulating chemo- and radiation resistance in nasopharyngeal carcinoma by controlling the cell cycle, proliferation, apoptosis, and DNA damage repair, as well as other signalling pathways. Recent research has suggested that selective modulation of ncRNA activity can improve the response to chemotherapy and radiotherapy, providing an innovative antitumour approach based on ncRNA-related gene therapy. Therefore, ncRNAs can serve as biomarkers for tumour prediction and prognosis, play a role in overcoming drug resistance and radiation resistance in NPC, and can also serve as targets for developing new therapeutic strategies. In this review, we discuss the involvement of ncRNAs in chemotherapy and radiation resistance in NPC. The effects of these molecules on predicting therapeutic cancer are highlighted.Keywords: miRNAs, lncRNAs, nasopharyngeal carcinoma, chemo- and radioresistanceXiao JHe XDove Medical Pressarticlemirnas，lncrnas，nasopharyngeal carcinoma，chemo- and radioresistanceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Management and Research, Vol Volume 13, Pp 8781-8794 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mirnas，lncrnas，nasopharyngeal carcinoma，chemo- and radioresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	mirnas，lncrnas，nasopharyngeal carcinoma，chemo- and radioresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiao J He X Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma
description	Jiaxin Xiao, Xiusheng He Hunan Province Key Laboratory of Tumour Cellular & Molecular Pathology Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang, 421001, Hunan Province, People’s Republic of ChinaCorrespondence: Xiusheng HeHunan Province Key Laboratory of Tumour Cellular & Molecular Pathology Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang, 421001, Hunan Province, People’s Republic of ChinaEmail hexiusheng168@163.comAbstract: The crucial treatment for nasopharyngeal carcinoma (NPC) is radiation therapy supplemented by chemotherapy. However, long-term radiation therapy can cause some genetic and proteomic changes to produce radiation resistance, leading to tumour recurrence and poor prognosis. Therefore, the search for new markers that can overcome the resistance of tumor cells to drugs and radiotherapy and improve the sensitivity of tumor cells to drugs and radiotherapy is one of the most important goals of pharmacogenomics and cancer research, which is important for predicting treatment response and prognosis. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), may play important roles in regulating chemo- and radiation resistance in nasopharyngeal carcinoma by controlling the cell cycle, proliferation, apoptosis, and DNA damage repair, as well as other signalling pathways. Recent research has suggested that selective modulation of ncRNA activity can improve the response to chemotherapy and radiotherapy, providing an innovative antitumour approach based on ncRNA-related gene therapy. Therefore, ncRNAs can serve as biomarkers for tumour prediction and prognosis, play a role in overcoming drug resistance and radiation resistance in NPC, and can also serve as targets for developing new therapeutic strategies. In this review, we discuss the involvement of ncRNAs in chemotherapy and radiation resistance in NPC. The effects of these molecules on predicting therapeutic cancer are highlighted.Keywords: miRNAs, lncRNAs, nasopharyngeal carcinoma, chemo- and radioresistance
format	article
author	Xiao J He X
author_facet	Xiao J He X
author_sort	Xiao J
title	Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma
title_short	Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma
title_full	Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma
title_fullStr	Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma
title_full_unstemmed	Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma
title_sort	involvement of non-coding rnas in chemo- and radioresistance of nasopharyngeal carcinoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4a2a9e4b094148f2ae64ac8dc18a638f
work_keys_str_mv	AT xiaoj involvementofnoncodingrnasinchemoandradioresistanceofnasopharyngealcarcinoma AT hex involvementofnoncodingrnasinchemoandradioresistanceofnasopharyngealcarcinoma
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Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma

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