The bone hormones and their potential effects on glucose and energy metabolism

The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of erythropoiesis. More recently, however, the identification of bone hormones has allowed us to envision bones as endocrine organs too. Within...

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Autores principales:	Addai Daniel, Zarkos Jacqueline, Tolekova Anna
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	osteocalcin lipocalin 2 glucose insulin energy metabolism Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/4a2cce5b476c4093914052f388965a68
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spelling	oai:doaj.org-article:4a2cce5b476c4093914052f388965a682021-12-02T17:49:33ZThe bone hormones and their potential effects on glucose and energy metabolism1336-032910.2478/enr-2019-0027https://doaj.org/article/4a2cce5b476c4093914052f388965a682019-10-01T00:00:00Zhttps://doi.org/10.2478/enr-2019-0027https://doaj.org/toc/1336-0329The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of erythropoiesis. More recently, however, the identification of bone hormones has allowed us to envision bones as endocrine organs too. Within the last few years, the bone hormones osteocalcin and lipocalin 2 have been implicated with glucose and energy metabolism. We systematically reviewed articles surrounding this subject and found a clear relationship between the osteocalcin levels and glucose tolerance and insulin sensitivity. We also found that many journals have shown the detrimental effects of an absences of lipocalin 2 from adipocytes. As osteocalcin administration to mice showed decreased blood glucose levels and promoted glucose tolerance and insulin sensitivity. Future studies could perhaps explore the use of osteocalcin as a supplement for type 2 diabetes.Addai DanielZarkos JacquelineTolekova AnnaSciendoarticleosteocalcinlipocalin 2glucoseinsulinenergy metabolismDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 53, Iss 4, Pp 268-273 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteocalcin lipocalin 2 glucose insulin energy metabolism Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	osteocalcin lipocalin 2 glucose insulin energy metabolism Diseases of the endocrine glands. Clinical endocrinology RC648-665 Addai Daniel Zarkos Jacqueline Tolekova Anna The bone hormones and their potential effects on glucose and energy metabolism
description	The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of erythropoiesis. More recently, however, the identification of bone hormones has allowed us to envision bones as endocrine organs too. Within the last few years, the bone hormones osteocalcin and lipocalin 2 have been implicated with glucose and energy metabolism. We systematically reviewed articles surrounding this subject and found a clear relationship between the osteocalcin levels and glucose tolerance and insulin sensitivity. We also found that many journals have shown the detrimental effects of an absences of lipocalin 2 from adipocytes. As osteocalcin administration to mice showed decreased blood glucose levels and promoted glucose tolerance and insulin sensitivity. Future studies could perhaps explore the use of osteocalcin as a supplement for type 2 diabetes.
format	article
author	Addai Daniel Zarkos Jacqueline Tolekova Anna
author_facet	Addai Daniel Zarkos Jacqueline Tolekova Anna
author_sort	Addai Daniel
title	The bone hormones and their potential effects on glucose and energy metabolism
title_short	The bone hormones and their potential effects on glucose and energy metabolism
title_full	The bone hormones and their potential effects on glucose and energy metabolism
title_fullStr	The bone hormones and their potential effects on glucose and energy metabolism
title_full_unstemmed	The bone hormones and their potential effects on glucose and energy metabolism
title_sort	bone hormones and their potential effects on glucose and energy metabolism
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/4a2cce5b476c4093914052f388965a68
work_keys_str_mv	AT addaidaniel thebonehormonesandtheirpotentialeffectsonglucoseandenergymetabolism AT zarkosjacqueline thebonehormonesandtheirpotentialeffectsonglucoseandenergymetabolism AT tolekovaanna thebonehormonesandtheirpotentialeffectsonglucoseandenergymetabolism AT addaidaniel bonehormonesandtheirpotentialeffectsonglucoseandenergymetabolism AT zarkosjacqueline bonehormonesandtheirpotentialeffectsonglucoseandenergymetabolism AT tolekovaanna bonehormonesandtheirpotentialeffectsonglucoseandenergymetabolism
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The bone hormones and their potential effects on glucose and energy metabolism

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