Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages

Type 2 diabetes is associated with impaired wound healing, which can lead to limb loss. Here, the authors show that in Type 2 diabetic mouse models, Dnmt1 is upregulated in hematopoietic stem cells, leading to impaired differentiation towards macrophages, reduced macrophage infiltration in the wound...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jinglian Yan, Guodong Tie, Shouying Wang, Amanda Tutto, Natale DeMarco, Lyne Khair, Thomas G. Fazzio, Louis M. Messina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a2e03c93405462e969dba52018c2d64
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4a2e03c93405462e969dba52018c2d64
record_format	dspace
spelling	oai:doaj.org-article:4a2e03c93405462e969dba52018c2d642021-12-02T15:34:45ZDiabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages10.1038/s41467-017-02425-z2041-1723https://doaj.org/article/4a2e03c93405462e969dba52018c2d642018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02425-zhttps://doaj.org/toc/2041-1723Type 2 diabetes is associated with impaired wound healing, which can lead to limb loss. Here, the authors show that in Type 2 diabetic mouse models, Dnmt1 is upregulated in hematopoietic stem cells, leading to impaired differentiation towards macrophages, reduced macrophage infiltration in the wound and skewed M1/M2 polarization.Jinglian YanGuodong TieShouying WangAmanda TuttoNatale DeMarcoLyne KhairThomas G. FazzioLouis M. MessinaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinglian Yan Guodong Tie Shouying Wang Amanda Tutto Natale DeMarco Lyne Khair Thomas G. Fazzio Louis M. Messina Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
description	Type 2 diabetes is associated with impaired wound healing, which can lead to limb loss. Here, the authors show that in Type 2 diabetic mouse models, Dnmt1 is upregulated in hematopoietic stem cells, leading to impaired differentiation towards macrophages, reduced macrophage infiltration in the wound and skewed M1/M2 polarization.
format	article
author	Jinglian Yan Guodong Tie Shouying Wang Amanda Tutto Natale DeMarco Lyne Khair Thomas G. Fazzio Louis M. Messina
author_facet	Jinglian Yan Guodong Tie Shouying Wang Amanda Tutto Natale DeMarco Lyne Khair Thomas G. Fazzio Louis M. Messina
author_sort	Jinglian Yan
title	Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
title_short	Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
title_full	Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
title_fullStr	Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
title_full_unstemmed	Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
title_sort	diabetes impairs wound healing by dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4a2e03c93405462e969dba52018c2d64
work_keys_str_mv	AT jinglianyan diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages AT guodongtie diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages AT shouyingwang diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages AT amandatutto diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages AT nataledemarco diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages AT lynekhair diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages AT thomasgfazzio diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages AT louismmessina diabetesimpairswoundhealingbydnmt1dependentdysregulationofhematopoieticstemcellsdifferentiationtowardsmacrophages
_version_	1718386779151663104

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages

Ejemplares similares